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Referencia número: HY-N9382

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Gnidimacrin

Gnidimacrin is a protein kinase C (PKC) activator. Gnidimacrin inhibits cell growth of human leukemias, stomach cancers and non-small cell lung cancers in vitro, and shows activity against murine leukemias and solid tumors in vivo. Gnidimacrin can be used for leukemias, stomach cancers and non-small cell lung cancers research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 60796-70-5
Fòrmula: C₄₄H₅₄O₁₂
Peso molecular:774.90

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Gnidimacrin Chemical Structure

No. CAS: 60796-70-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas PKC :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	>=1.29 μM Compound: 10	Cytotoxicity against human MT4 cells by cellTiterGlo assay Cytotoxicity against human MT4 cells by cellTiterGlo assay	[PMID: 26562066]
MT4	CC₅₀	>1 nM Compound: 1; GM	Cytotoxicity against human MT4 cells measured after 3 days by CytoTox-Glo assay Cytotoxicity against human MT4 cells measured after 3 days by CytoTox-Glo assay	[PMID: 31343875]
MT4	CC₅₀	>5 nM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as reduction in cell viability by CellTiter-Glo luminescence analysis Cytotoxicity against human MT4 cells assessed as reduction in cell viability by CellTiter-Glo luminescence analysis	[PMID: 34445872]
MT4	CC₅₀	>6.5 μM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as reduction in cell viability by celltiter-glo luminescent cell viability assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability by celltiter-glo luminescent cell viability assay	[PMID: 36516989]
MT4	CC₅₀	>7 μM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as reduction in cell viability by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability by CellTiter-Glo luminescent cell viability assay	[PMID: 35698995]
MT4	CC₅₀	5 nM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	[PMID: 33172265]
MT4	EC₅₀	0.00006 μM Compound: 10	Antiviral activity against HIV-1 NL4-3 infected in MT4 cells assessed as viral replication measured on day 4 post infection by ELISA Antiviral activity against HIV-1 NL4-3 infected in MT4 cells assessed as viral replication measured on day 4 post infection by ELISA	[PMID: 26562066]
MT4	IC₅₀	>32 nM Compound: Gnidimacrin	Cytotoxicity against human MT4 cells assessed as inhibition of cell growth by measuring ATP by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MT4 cells assessed as inhibition of cell growth by measuring ATP by CellTiter-Glo luminescent cell viability assay	[PMID: 36169204]
MT4	IC₅₀	0.13 nM Compound: 1; GM	Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-infection by Nano-Glo luciferase assay Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-infection by Nano-Glo luciferase assay	[PMID: 31343875]
U1	EC₅₀	0.19 nM Compound: 1; GM	Agonist activity at Protein kinase C in human U1 cells infected with HIV-1 NL4-3 assessed as induction of HIV-1 p24 production after 72 hrs by ELISA Agonist activity at Protein kinase C in human U1 cells infected with HIV-1 NL4-3 assessed as induction of HIV-1 p24 production after 72 hrs by ELISA	[PMID: 31343875]

Chemical Information

No. CAS 60796-70-5
Peso molecular 774.90
Fòrmula C₄₄H₅₄O₁₂
SMILES

C(OC(=O)C1=CC=CC=C1)[C@H]2[C@@]34[C@]5([C@]6([C@](CO)(O6)[C@@H](O)[C@@]7(O)[C@]3([C@]([C@H](C)[C@@H]7OC(=O)C8=CC=CC=C8)([C@H](C)CCCCCC[C@@H](O)[C@@]9(O4)O[C@]5([C@](C(C)=C)(C2)O9)[H])[H])[H])[H])[H]
Structure Classification
- Others
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yoshida M, et al. Antitumor activity of daphnane-type diterpene gnidimacrin isolated from Stellera chamaejasme L. Int J Cancer. 1996 Apr 10;66(2):268-73. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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