IQ-3
Based on 2 publication(s) in Google Scholar
IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.61%
- No. CAS: 312538-03-7
- Fòrmula: C20H11N3O3
- Peso molecular:341.32
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) IQ-3
More
Actividad biológica
Descripciòn
IC50 & Target
[1]|
JNK3 0.066 μM (Kd) |
JNK1 0.24 μM (Kd) |
JNK2 0.29 μM (Kd) |
CK1δ 0.56 μM (Kd) |
PI3Kγ 0.43 μM (Kd) |
MKNK2 1.2 μM (Kd) |
In Vitro
IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively[1].
IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells[1].
IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PBMCs.
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Concentration:0-80 μM (200 ng/mL LPS).
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Incubation Time:30 min.
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Result:Downregulated TNF-α concentration (IC50 = 4.7 μM).
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 312538-03-7
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Appearance Solid
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Peso molecular 341.32
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Fòrmula C20H11N3O3
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Color Off-white to light yellow
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SMILES
O=C(O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2)C5=CC=CO5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Ethnopharmacol
Compound Danshen Dripping Pill ameliorates post ischemic myocardial inflammation through synergistically regulating MAPK, PI3K/AKT and PPAR signaling pathways. [Abstract]2021 Dec 5:281:114438. PMID: 34390798 -
Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (73.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 1.25 mg/mL (3.66 mM); Suspended solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.9298 mL | 14.6490 mL | 29.2980 mL | 73.2450 mL |
| 5 mM | 0.5860 mL | 2.9298 mL | 5.8596 mL | 14.6490 mL | |
| 10 mM | 0.2930 mL | 1.4649 mL | 2.9298 mL | 7.3245 mL | |
| 15 mM | 0.1953 mL | 0.9766 mL | 1.9532 mL | 4.8830 mL | |
| 20 mM | 0.1465 mL | 0.7325 mL | 1.4649 mL | 3.6623 mL | |
| 25 mM | 0.1172 mL | 0.5860 mL | 1.1719 mL | 2.9298 mL | |
| 30 mM | 0.0977 mL | 0.4883 mL | 0.9766 mL | 2.4415 mL | |
| 40 mM | 0.0732 mL | 0.3662 mL | 0.7325 mL | 1.8311 mL | |
| 50 mM | 0.0586 mL | 0.2930 mL | 0.5860 mL | 1.4649 mL | |
| 60 mM | 0.0488 mL | 0.2442 mL | 0.4883 mL | 1.2208 mL |
IQ-3 Related Classifications
HY-107600 Related Classifications
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