KL-50
Based on 1 Customer Validation
KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.82%
- No. CAS: 1161826-19-2
- Fòrmula: C7H7FN6O2
- Peso molecular:226.17
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Chemical Information
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No. CAS 1161826-19-2
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Appearance Solid
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Peso molecular 226.17
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Fòrmula C7H7FN6O2
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Color Off-white to pink
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SMILES
O=C(C(N=CN12)=C2N=NN(CCF)C1=O)N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (442.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4215 mL | 22.1073 mL | 44.2145 mL | 110.5363 mL |
| 5 mM | 0.8843 mL | 4.4215 mL | 8.8429 mL | 22.1073 mL | |
| 10 mM | 0.4421 mL | 2.2107 mL | 4.4215 mL | 11.0536 mL | |
| 15 mM | 0.2948 mL | 1.4738 mL | 2.9476 mL | 7.3691 mL | |
| 20 mM | 0.2211 mL | 1.1054 mL | 2.2107 mL | 5.5268 mL | |
| 25 mM | 0.1769 mL | 0.8843 mL | 1.7686 mL | 4.4215 mL | |
| 30 mM | 0.1474 mL | 0.7369 mL | 1.4738 mL | 3.6845 mL | |
| 40 mM | 0.1105 mL | 0.5527 mL | 1.1054 mL | 2.7634 mL | |
| 50 mM | 0.0884 mL | 0.4421 mL | 0.8843 mL | 2.2107 mL | |
| 60 mM | 0.0737 mL | 0.3685 mL | 0.7369 mL | 1.8423 mL | |
| 80 mM | 0.0553 mL | 0.2763 mL | 0.5527 mL | 1.3817 mL | |
| 100 mM | 0.0442 mL | 0.2211 mL | 0.4421 mL | 1.1054 mL |
KL-50 Related Classifications
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