LASSBio-2389
LASSBio-2389 is a selective ROCK2 inhibitor with an IC50 of 0.051 μM and an IC50 of 1.143 μM against ROCK1. LASSBio-2389 reduces the viability of MDA-MB-231 cells and inhibits cell migration. LASSBio-2389 is applicable to the research of triple-negative breast cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2671377-38-9
- Fòrmula: C18H18N4O4
- Peso molecular:354.36
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
ROCK1 1.143 μM (IC50) |
ROCK2 0.051 μM (IC50) |
LASSBio-2389 exhibits high passive permeability in gastrointestinal tract models, but shows no permeability in blood-brain barrier models[1].
LASSBio-2389 (30 μM; 24 h) reduces the viability of MDA-MB-231 cells[1].
LASSBio-2389 (0.1-100 μM; 24 h) potently inhibits the migration of MDA-MB-231 cells at concentrations as low as 0.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 triple-negative breast cancer cells
-
Concentration:30 μM
-
Incubation Time:24 h
-
Result:Reduced MDA-MB-231 cell viability by 26.2% (73.8% viability relative to vehicle control).
Chemical Information
-
No. CAS 2671377-38-9
-
Peso molecular 354.36
-
Fòrmula C18H18N4O4
-
SMILES
O=C(C1=CC(OC)=C(OC)C(OC)=C1)N/N=C/C2=CC(C=NN3)=C3C=C2
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LASSBio-2389 Related Classifications
HY-181583 Related Classifications
Powered by Bioz