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Referencia número: HY-118760

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Litebamine

Litebamine is a phenanthrene alkaloid with antiplatelet activity. Litebamine potently targets arachidonic acid- and collagen-induced platelet aggregation, but shows no activity against thrombin-induced aggregation. Litebamine inhibits arachidonic acid- and collagen-induced ATP release and thromboxane B₂ production in rabbit platelets, without altering cyclic AMP levels or phosphoinositide breakdown in rabbit platelets. Litebamine has no effect on platelet-activating factor- or U46619 (HY-108566)-induced aggregation, nor does it affect [³H] inositol monophosphate production in rabbit platelets induced by collagen, platelet-activating factor or thrombin.

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No. CAS: 137031-56-2
Fòrmula: C₂₀H₂₁NO₄
Peso molecular:339.39

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Litebamine Chemical Structure

No. CAS: 137031-56-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Prostaglandin Receptor :

In Vitro

Litebamine (1.5-60 μM; 3 min) suppresses adrenaline- and ADP-induced secondary aggregation (but not primary aggregation) in human platelet-rich plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

human platelet-rich plasma
Concentration:

1.5-60 μM
Incubation Time:

3 min
Result:

Completely inhibited at 30 μM for adrenaline-induced secondary aggregation and 60 μM for ADP-induced secondary aggregation.

Chemical Information

No. CAS 137031-56-2
Peso molecular 339.39
Fòrmula C₂₀H₂₁NO₄
SMILES

OC(C=C1C=CC2=C(CCN(C3)C)C3=C4O)=C(OC)C=C1C2=C4OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Teng CM, et al. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. The Journal of pharmacy and pharmacology. 1997 Jul;49(7):706-11. [Content Brief]

[2]. Wu Y C, et al. Litebamine, a novel phenanthrene alkaloid from Litsea cubeba[J]. Tetrahedron letters, 1991, 32(33): 4169-4170.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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