LN5972
LN5972 is a selective ACKR3 agonist with an EC50 of 3.40 μM, showing higher selectivity for ACKR3 over CXCR4. LN5972 induces β-arrestin recruitment to ACKR3/CXCR7. LN5972 reduces the surface expression of P-selectin. LN5972 is applicable to studies related to platelet-mediated thrombosis.
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- No. CAS: 3035425-93-2
- Fòrmula: C19H30N6O3S
- Peso molecular:422.54
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
ACKR3 3.40 μM (EC50) |
In Vitro
LN5972 (0.3 nM-100 μM) acts as a superagonist for ACKR3 in HEK293T cells, inducing β-arrestin recruitment with an EC50 of 3.40 μM and a maximal efficacy 161% that of CXCL12[1].
LN5972 (100 μM; 15 min preincubation) reduces CRP-XL-induced P-selectin expression by 76% in human platelet-rich plasma[1].
LN5972 (0.3 nM-100 μM) is selective for ACKR3 and shows no activity at CXCR4 in HEK293T cells[1].
LN5972 shows high metabolic stability in human liver microsomes (87% remaining at 120 min) and reduced stability in mouse liver microsomes[1].
LN5972 (up to 100 μM; 72 h) is non-cytotoxic to THP1 and HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 3035425-93-2
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Peso molecular 422.54
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Fòrmula C19H30N6O3S
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SMILES
O=C(N1CCN(CCCNC2=NN3C(C=C(CC)N=C3S2)=O)CC1)OC(C)(C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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