Methylliberine
Based on 1 Customer Validation
Methylliberine is an orally active adenosine A1 receptor modulator. Methylliberine inhibits spermatogenesis and induces testicular atrophy.
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- Pureza : 99.94%
- No. CAS: 51168-26-4
- Fòrmula: C9H12N4O3
- Peso molecular:224.22
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Methylliberine (125-2000 µg/mL; 3-28 h) is non-clastogenic in V79 male Chinese hamster lung cells under short-term exposure up to 2000 µg/mL and long-term exposure up to 500 µg/mL, with and without S9 metabolic activation[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 51168-26-4
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Appearance Solid
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Peso molecular 224.22
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Fòrmula C9H12N4O3
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Color White to off-white
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SMILES
O=C1C2=C(N(C)C(N2C)=O)N=C(N1C)OC
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 1 mg/mL (4.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Tartar JL, et al. A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers. Cureus. 2021 Dec;13(12):e20534. [Content Brief]
[5]. Murbach TS, et al. A Toxicological Evaluation of Methylliberine (Dynamine®). Journal of toxicology. 2019;2019:4981420. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4599 mL | 22.2995 mL | 44.5991 mL | 111.4976 mL |
Methylliberine Related Classifications
HY-N7564 Related Classifications
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Keywords
- Methylliberine
- 51168-26-4
- Adenosine Receptor
- 1,3,7-trimethylxanthine catabolism
- C-8 oxidation pathway
- S9 metabolic activation
- adenosine A1 receptor
- adenosine receptors
- bacterial reverse mutation test
- bone marrow micronucleus test
- mammalian chromosomal aberration test
- spermatogenesis
- testicular atrophy
- Inhibitor
- inhibitor
- inhibit