Misonidazole
Misonidazole (Ro 7-0582; SR 1354) is a hypoxic tumor cell radiosensitizer. Misonidazole also has antimicrobial effects.
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- No. CAS: 13551-87-6
- Fòrmula: C7H11N3O4
- Peso molecular:201.18
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-AA8 | IC50 |
12 mM
Compound: 1
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Aerobic growth inhibition in Chinese hamster cell line AA8
Aerobic growth inhibition in Chinese hamster cell line AA8
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[PMID: 7783125] |
| CHO-AA8 | IC50 |
12.1 mM
Compound: 1
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Concentration required to reduce AA8 cell numbers to 50% of controls in a growth inhibition microassay
Concentration required to reduce AA8 cell numbers to 50% of controls in a growth inhibition microassay
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[PMID: 8308864] |
| CHO-AA8 | IC50 |
12080 μM
Compound: 1 (misonidazole)
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Growth inhibition in CHO subline AA8 cells exposed for 18 hr under aerobic(air) conditions
Growth inhibition in CHO subline AA8 cells exposed for 18 hr under aerobic(air) conditions
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[PMID: 1479583] |
| HCT-116 | IC50 |
0.53 mM
Compound: 1
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Cytotoxicity against human HCT116 cells incubated for 4 hrs under anaerobic condition measured after 5 days by sulforhodamine B assay
Cytotoxicity against human HCT116 cells incubated for 4 hrs under anaerobic condition measured after 5 days by sulforhodamine B assay
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[PMID: 29253343] |
Chemical Information
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No. CAS 13551-87-6
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Appearance Solid
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Peso molecular 201.18
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Fòrmula C7H11N3O4
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Color Off-white to yellow
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SMILES
COCC(O)CN1C([N+]([O-])=O)=NC=C1
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Synonyms
Ro 7-0582; SR 1354
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Bibo Li, et al. Preparation, Characterization, and In Vitro pH-sensitivity Evaluation of Superparamagnetic Iron Oxide Nanoparticle- Misonidazole pH-sensitive Liposomes. Curr Drug Deliv. 2019;16(3):254-267. [Content Brief]
[2]. R C Knight, et al. Mechanism of action of nitroimidazole antimicrobial and antitumour radiosensitizing drugs. Effects of reduced misonidazole on DNA. Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Oct;36(4):367-77. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Misonidazole Related Classifications
HY-105061 Related Classifications
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