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Referencia número: HY-11072

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MK-0359

(Synonyms: L-454,560)

MK-0359 (L-454,560) is a selective and orally active PDE4 inhibitor, and can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 346629-30-9
Fòrmula: C₃₁H₂₉N₃O₅S₂
Peso molecular:587.71

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

MK-0359 Chemical Structure

No. CAS: 346629-30-9

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Actividad biológica
- Descripciòn
- Cellular Effect
- Ensayo clínico
Chemical Information
Pureza y Documentación
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Bioz

Actividad biológica

Descripciòn

MK-0359 (L-454,560) is a selective and orally active PDE4 inhibitor, and can be used for asthma and chronic obstructive pulmonary disease (COPD) research^[1].

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE) :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	49.9 μM Compound: 3	Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells	[PMID: 18835163]
Sf21	IC₅₀	3.9 μM Compound: 4, L-454560	Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB2 expressed in baculovirus infected insect Sf21 cells Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB2 expressed in baculovirus infected insect Sf21 cells	[PMID: 22023548]
Sf21	IC₅₀	8.8 μM Compound: 4, L-454560	Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB1 expressed in baculovirus infected insect Sf21 cells Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB1 expressed in baculovirus infected insect Sf21 cells	[PMID: 22023548]
Sf9	IC₅₀	1.4 nM Compound: 3	Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cells Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cells	[PMID: 18835163]
Sf9	IC₅₀	3 nM Compound: 1, L-454560	Inhibition of PDE4 expressed in SF9 cells Inhibition of PDE4 expressed in SF9 cells	[PMID: 18207397]

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 346629-30-9
Peso molecular 587.71
Fòrmula C₃₁H₂₉N₃O₅S₂
SMILES

O=S(C1=CC=C(/C(C2=NC(C)=NO2)=C\C3=CC(C4=C5N=CC=CC5=CC(C(S(=O)(C)=O)(C)C)=C4)=CC=C3)C=C1)(C)=O
Synonyms

L-454,560
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Lu S, et al. Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma. Respir Med. 2009 Mar;103(3):342-7. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- Ensayo clínico
Chemical Information
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MK-0359

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE)

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

MK-0359 Related Classifications

HY-11072 Related Classifications