Niloticin
Based on 1 Customer Validation
Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.0%
- No. CAS: 115404-57-4
- Fòrmula: C30H48O3
- Peso molecular:456.70
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
5.9 μM
Compound: 21
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability by SRB assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability by SRB assay
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[PMID: 38970504] |
| KB | IC50 |
4.6 μM
Compound: 21
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Antiproliferative activity against human KB cells assessed as reduction in cell viability by SRB assay
Antiproliferative activity against human KB cells assessed as reduction in cell viability by SRB assay
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[PMID: 38970504] |
| MCF7 | IC50 |
6.9 μM
Compound: 21
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability by SRB assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability by SRB assay
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[PMID: 38970504] |
| MDA-MB-231 | IC50 |
7.1 μM
Compound: 21
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability by SRB assay
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[PMID: 38970504] |
Chemical Information
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No. CAS 115404-57-4
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Appearance Solid
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Peso molecular 456.70
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Fòrmula C30H48O3
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Color White to off-white
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SMILES
C[C@@]1(CC[C@@]2([H])[C@@H](C)C[C@H]([C@@](O3)([H])C3(C)C)O)C([C@]4([H])CC[C@]12C)=CC[C@](C(C)5C)([H])[C@@]4(CCC5=O)C
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
In Vitro:
Acetone : ≥ 25 mg/mL (54.74 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Acetone | 1 mM | 2.1896 mL | 10.9481 mL | 21.8962 mL | 54.7405 mL |
| 5 mM | 0.4379 mL | 2.1896 mL | 4.3792 mL | 10.9481 mL | |
| 10 mM | 0.2190 mL | 1.0948 mL | 2.1896 mL | 5.4741 mL | |
| 15 mM | 0.1460 mL | 0.7299 mL | 1.4597 mL | 3.6494 mL | |
| 20 mM | 0.1095 mL | 0.5474 mL | 1.0948 mL | 2.7370 mL | |
| 25 mM | 0.0876 mL | 0.4379 mL | 0.8758 mL | 2.1896 mL | |
| 30 mM | 0.0730 mL | 0.3649 mL | 0.7299 mL | 1.8247 mL | |
| 40 mM | 0.0547 mL | 0.2737 mL | 0.5474 mL | 1.3685 mL | |
| 50 mM | 0.0438 mL | 0.2190 mL | 0.4379 mL | 1.0948 mL |
Niloticin Related Classifications
HY-N3188 Related Classifications
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