Paramethasone
Paramethasone is an orally active long-acting glucocorticoid. Paramethasone directly inhibits testicular aromatase, thereby reducing the synthesis of estradiol. Paramethasone suppresses the basal and midcycle luteinizing hormone surges in female animals and blocks estrogen synthesis. Paramethasone also decreases circulating levels of dihydrotestosterone, androstenedione and estradiol in male animals. Paramethasone inhibits cartilage degeneration and alleviates joint pathological damage in osteoarthritis models. Paramethasone can be used in research related to osteoarthritis and endocrinology.
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- No. CAS: 53-33-8
- Fòrmula: C22H29FO5
- Peso molecular:392.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand white (male, ~4 kg, surgically induced model)[2]
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Dosage:0.1 mg/kg
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Administration:p.o.; 5 days per week; 5 weeks
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Result:Reduced global lesion scores for tibial and femoral cartilage significantly relative to controls.
Maintained cartilage architecture.
Partially prevented chondrocyte loss and stainable proteoglycan loss.
Markedly reduced the incidence and severity of osteophytes.
Reduced the size and number of chondrocyte clones.
Lowered the incidence and severity of ulcers and fissures.
Chemical Information
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No. CAS 53-33-8
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Peso molecular 392.46
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Fòrmula C22H29FO5
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SMILES
C[C@@]12[C@](C[C@H]([C@]2(O)C(CO)=O)C)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C([C@H](C3)F)=CC(C=C4)=O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Cortés-Gallegos V, et al. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic pituitary-gonadal axis. J Steroid Biochem. 1984;20(1):353-356. [Content Brief]
[2]. Colombo C, et al. A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically. Arthritis Rheum. 1983 Sep;26(9):1132-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Paramethasone Related Classifications
HY-A0179 Related Classifications
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