PJ17
PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease.
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- No. CAS: 2248983-31-3
- Fòrmula: C15H13FN4O2
- Peso molecular:300.29
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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AChE 8.84 μM (IC50) |
GSK-3β 4.19 μM (IC50) |
PJ17 (30-100 μM) potently inhibits AChE with an IC50 of 8.84 μM[1].
PJ17 (10 μM) potently inhibits human recombinant GSK-3β with an IC50 of 4.19 μM, achieving 85.95% inhibition at 10 μM[1].
PJ17 (2.5-50 μM; 24-48 h) does not induce neurotoxicity in primary CGN cultures at concentrations up to 50 μM, and increases cell viability at 10-50 μM[1].
PJ17 (2.5-50 μM; 1-24 h pretreatment) does not exhibit significant neuroprotective activity against Rotenone (HY-B1756)-induced toxicity in primary CGN cultures at concentrations up to 50 μM[1].
PJ17 does not significantly inhibit rat MAO-A, MAO-B and human recombinant BACE-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary cerebellar granule neurons (CGNs) cultures
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Concentration:2.5, 5, 10, 25, 50 μM
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Incubation Time:24 h, 48 h
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Result:Showed no significant decrease in cell viability after 24 or 48 h of incubation at any tested concentration.
Increased cell viability at 10-50 μM.
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Cell Line:Primary cerebellar granule neurons (CGNs) cultures
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Concentration:2.5, 5, 10, 25, 50 μM
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Incubation Time:1 h pretreatment, 24 h pretreatment; 24 h Rotenone (HY-B1756) exposure
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Result:Did not significantly prevent rotenone-induced cell viability reduction.
Chemical Information
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No. CAS 2248983-31-3
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Peso molecular 300.29
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Fòrmula C15H13FN4O2
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SMILES
O=C(C1CC1)NC2=NC=CC(C(NC3=C(C=NC=C3)F)=O)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PJ17 Related Classifications
HY-181811 Related Classifications
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- PJ17
- 2248983-31-3
- PJ 17
- PJ-17
- Cholinesterase (ChE)
- GSK-3
- nAChR7
- primary cerebellar granule neuron cultures
- acetylcholinesterase
- human glycogen synthase kinase 3 beta
- electric eel acetylcholinesterase
- glycogen synthase kinase 3 beta
- BOSC-23 cells
- Alzheimer's disease
- Electrophorus electricus
- GSK-3β
- Inhibitor
- inhibitor
- inhibit