Copy Link Print Information

Precemtabart

(Synonyms: MBE-748; M-9140 Antibody; MBE-2882 Antibody)
Revisión del cliente

Based on 1 Customer Validation

Precemtabart is a humanized IgG1 antibody targeting CEACAM5, with selectivity for CEACAM5-positive cells. Precemtabart binds to CEACAM5 on tumor cells to deliver the topoisomerase 1 inhibitor Exatecan (HY-13631), and induces cell death by inhibiting the function of TOP1. Precemtabart inhibits the growth of CEACAM5-positive cancer cells. Precemtabart causes dose-dependent hematolymphoid and intestinal-related effects in cynomolgus monkeys. Precemtabart can be used in research related to metastatic colorectal cancer, metastatic pancreatic ductal carcinoma, advanced gastric cancer, advanced non-small cell lung cancer, and advanced pancreatic adenocarcinoma.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 99.00%
  • No. CAS: 2883118-92-9
  • Peso molecular:144.471 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Precemtabart
  • Experimental Validation Results for Precemtabart
  • Experimental Validation Results for Precemtabart
  • Precemtabart Chemical Structure
    Precemtabart Chemical Structure
No. CAS: 2883118-92-9
Tamaño
Precio
Stock
Cantidad
Amount: USD 0.00
Please select quantity
or
or

* Seleccione Cantidad antes de agregar artículos.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Precemtabart Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
  • Actividad biológica
  • Chemical Information
  • Pureza y Documentación
  • Referencias
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Ver todos los productos específicos de isoformas Topoisomerase

More
Keywords
MOQ
Minimum order quantity
100 mg

Obtener un presupuesto En stock

Other size
Obtener un presupuesto
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Inicie sesiòn
Registrar
Sign in to MedChemExpress
Registrar una cuenta nueva

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • 1/16

    IgG1-kappa

  • 1/16

    Loaded Precemtabart on AHC2 biosensor, can bind CEACAM5 Protein, Human (HEK293, His, HY-P70675) with an affinity constant of 3.214E-09 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Precemtabart (HY-P990940, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Precemtabart Chemical Structure
    1/16
  • Precemtabart
  • Loaded Precemtabart on AHC2 biosensor, can bind CEACAM5 Protein, Human (HEK293, His, HY-P70675) with an affinity constant of 3.214E-09 M as determined in BLI assay.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Precemtabart (HY-P990940, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG1-kappa