SC-77964
SC-77964 is a potent, selective and orally active matrix metalloprotease (MMP) inhibitor. SC-77964 shows IC50 values < 0.1 nM against MMP-2, MMP-9, and MMP-13. SC-77964 can be used for the research of cancer and inflammation, such as melanoma.
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- No. CAS: 308824-37-5
- Fòrmula: C22H23F3N2O6S
- Peso molecular:500.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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MMP-2 < 0.1 nM (IC50) |
MMP-9 < 0.1 nM (IC50) |
MMP13 < 0.1 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HT-1080 | IC50 |
4000 nM
Compound: 19w, SC-77964
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Inhibition of human MMP1 expressed in human HT-1080 cells assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay
Inhibition of human MMP1 expressed in human HT-1080 cells assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay
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[PMID: 20726512] |
Chemical Information
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No. CAS 308824-37-5
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Peso molecular 500.49
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Fòrmula C22H23F3N2O6S
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SMILES
O=C(C1(S(=O)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O)CCN(C4CC4)CC1)NO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SC-77964 Related Classifications
HY-14237 Related Classifications
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