SLD1121
SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research.
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- No. CAS: 2759011-75-9
- Fòrmula: C26H17N5O
- Peso molecular:415.45
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Almacenamiento:
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Actividad biológica
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Chemical Information
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Actividad biológica
SLD1121 (0-2 μM; 24 h) activates the LRP6-mediated Wnt/β-catenin signaling pathway in HEK293T cells, with an EC50 of approximately 0.21 μM[1].
SLD1121 (1-2 μM; 24 h) activates the Wnt/β-catenin signaling pathway in HaCaT cells[1].
SLD1121 (0.25-2 μM; 4-24 h) dose- and time-dependently increases the levels of total LRP6 protein, phosphorylated LRP6 protein, as well as ABC and β-catenin in HEK293T and HaCaT cells, without altering the mRNA expression level of LRP6[1].
SLD1121 (2 μM; 24 h) directly interacts with LRP6 in HEK293T cells and increases the thermal stability of both endogenous and exogenous LRP6[1].
SLD1121 (0-2 μM; 12-24 h) promotes the nuclear translocation of LRP6 and increases the nuclear β-catenin level in HaCaT cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT cells
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Concentration:1 and 2 μM
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Incubation Time:24 h
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Result:Upregulated the mRNA expression of Wnt target genes Axin2, LEF1, Snail1, OCT4, Twist1, Sox2, and CD44.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (7-week-old female, depilated to induce synchronized hair follicle telogen phase)[1]
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Dosage:2%
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Administration:topical; daily; 17 days
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Result:Induced gray skin (indicating early anagen transition) on day 9.
Showed significantly higher hair coat recovery rates compared to vehicle controls on days 11, 15, and 17.
Increased regrown hair weight significantly relative to vehicle controls on day 17.
Increased anagen-phase hair follicle numbers and dermal thickness compared to vehicle-treated mice (remained in telogen) via histological H&E staining.
Upregulated protein levels of phosphorylated LRP6, total LRP6, ABC, β-catenin, cytokeratin 15, and cytokeratin 17 significantly via western blotting.
Increased expression of LRP6, β-catenin, ABC, cytokeratin 15, cytokeratin 17, and proliferative marker Ki67 in skin tissues confirmed via immunohistochemical staining.
Increased expression of Sox2 and Snail in hair follicles shown via immunofluorescence staining.
Chemical Information
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No. CAS 2759011-75-9
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Peso molecular 415.45
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Fòrmula C26H17N5O
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SMILES
O=C(NC1=CC=CC=C1)C(C=C2)=CC=C2C3=NC4=C5C(N=CC=C5)=C6C(C=CC=N6)=C4N3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SLD1121 Related Classifications
HY-181560 Related Classifications
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