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Referencia número: HY-136994

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Sphingolactone-24

(Synonyms: Sph-24)

Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury.

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No. CAS: 881177-99-7
Fòrmula: C₁₈H₂₉NO₄
Peso molecular:323.43

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Sphingolactone-24 Chemical Structure

No. CAS: 881177-99-7

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Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury^[1].

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In Vitro

Sphingolactone-24 (50 µM; 30 min+24 h) inhibits LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect LPS (HY-D1056)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

human neutrophils
Concentration:

50 µM
Incubation Time:

30 min +24 h (30 min before LPS (500 ng/ml) treatment)
Result:

Inhibited LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect of LPS.

In Vivo

Sphingolactone-24 (1 mg/kg; i.p.; 3 and 9 h thereafter LPS) reduces the severity of LPS-induced ALI and increases the survival rate of LPS-induced lung injury mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H/HeN breeder mice (LPS 10 mg/kg; intranasal instillation)^[1]
Dosage:

1 mg/kg
Administration:

I.p.; 3 and 9 h thereafter LPS
Result:

Improved survival and reduced the severity of LPS-induced acute lung injury (ALI).

Chemical Information

No. CAS 881177-99-7
Peso molecular 323.43
Fòrmula C₁₈H₂₉NO₄
SMILES

C/C=C/C=C/C(N[C@H]([C@@]1([H])CC(C(O1)=O)CCCCCC)CO)=O
Synonyms

Sph-24
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Lin WC, et al. Inhibition of neutrophil apoptosis via sphingolipid signaling in acute lung injury. J Pharmacol Exp Ther. 2011 Oct;339(1):45-53. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
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Sphingolactone-24

Ver todos los productos específicos de isoformas Phospholipase