SU0383
SU0383 is a dual MTH1 and OGG1 inhibitor with IC50 values of 0.034 μM and 0.49 μM, respectively. SU0383 induces cytotoxicity in cancer cells and increases sensitivity of tumor cells to oxidative stress, and showing low toxicity in normal cells. SU0383 can be used for cancer research.
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- No. CAS: 2598151-90-5
- Fòrmula: C33H34N6O5S
- Peso molecular:626.73
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Actividad biológica
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MTH1 0.034 μM (IC50) |
OGG1 0.49 μM (IC50) |
SU0383 (5-20 µM; 24-72 h) induces cytotoxicity at 20 μM in A549, H460, and HCT116 cells[1].
SU0383 (0.01-10 μM; 24 h) shows low toxicity in MCF-7 and HeLa cells[2].
SU0383 (10 μM; 16 h) increases the sensitivity of MCF-7 tumor cells to oxidative stress induced by hydrogen peroxide[2].
SU0383 (10 μM) engages native NUDT1 in MCF7 cells and inhibits native OGG1 activity in MCF7 lysate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, H460, HCT116
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Concentration:5-20 μM
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Incubation Time:24, 48, 72 h
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Result:Induced noticeable cytotoxicity only at 20 μM in A549, H460, and HCT116 cells.
Showed no significant cytotoxicity at lower concentrations.
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Cell Line:MCF-7 and HeLa human cell lines
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Concentration:0.01, 0.1, 1, 10 μM
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Incubation Time:24 h
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Result:Displayed little or no measurable toxicity in MCF-7 and HeLa cells at concentrations up to 10 μM.
Chemical Information
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No. CAS 2598151-90-5
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Peso molecular 626.73
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Fòrmula C33H34N6O5S
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SMILES
O=C(NCCOC1=NC(=NC=C1C)N)C=2C=CC=C(C2)C=3C=CC(=CC3)S(=O)(=O)NC4=CC=C5C(=C4)N(C(=O)C6CC6)CCC5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SU0383 Related Classifications
HY-180404 Related Classifications
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