Tilivapram
Based on 1 Customer Validation
Tilivapram (AVE8112) is an orally active PDE4 inhibitor with procognitive effects. Tilivapram exhibits in vivo efficacy and improves processing speed and psychomotor speed. Oral administration of tilivapram may induce dose-related adverse reactions such as nausea and dizziness, but transdermal delivery enables slow, controlled elevation of plasma concentrations, thereby significantly reducing gastrointestinal discomfort and dizziness. Tilivapram is applicable to research related to neuropsychiatric disorders.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.96%
- No. CAS: 166741-91-9
- Fòrmula: C16H15Cl2N3O4
- Peso molecular:384.21
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Clinical Compound Library
HY-L026
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HY-L026P
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Actividad biológica
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PDE4 |
Tilivapram has a wide therapeutic window within the dose range of 0.5 mg to 1.5 mg. Tilivapram modulates electroencephalogram features (such as reducing resting-state θ power, enhancing θ coherence and γ phase-locking during stimulus processing) and mismatch negativity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 166741-91-9
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Appearance Solid
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Peso molecular 384.21
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Fòrmula C16H15Cl2N3O4
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Color Off-white to light yellow
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SMILES
ClC1=C(NC(C2=NC=C(OC)C(OCC3CC3)=C2)=O)C(Cl)=C[N+]([O-])=C1
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Synonyms
AVE8112
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (130.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6027 mL | 13.0137 mL | 26.0274 mL | 65.0686 mL |
| 5 mM | 0.5205 mL | 2.6027 mL | 5.2055 mL | 13.0137 mL | |
| 10 mM | 0.2603 mL | 1.3014 mL | 2.6027 mL | 6.5069 mL | |
| 15 mM | 0.1735 mL | 0.8676 mL | 1.7352 mL | 4.3379 mL | |
| 20 mM | 0.1301 mL | 0.6507 mL | 1.3014 mL | 3.2534 mL | |
| 25 mM | 0.1041 mL | 0.5205 mL | 1.0411 mL | 2.6027 mL | |
| 30 mM | 0.0868 mL | 0.4338 mL | 0.8676 mL | 2.1690 mL | |
| 40 mM | 0.0651 mL | 0.3253 mL | 0.6507 mL | 1.6267 mL | |
| 50 mM | 0.0521 mL | 0.2603 mL | 0.5205 mL | 1.3014 mL | |
| 60 mM | 0.0434 mL | 0.2169 mL | 0.4338 mL | 1.0845 mL | |
| 80 mM | 0.0325 mL | 0.1627 mL | 0.3253 mL | 0.8134 mL | |
| 100 mM | 0.0260 mL | 0.1301 mL | 0.2603 mL | 0.6507 mL |
Tilivapram Related Classifications
HY-14826 Related Classifications
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