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Referencia número: HY-151259

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TK4b

TK4b is a dual JAK2/3 inhibitor with human JAK2 and JAK3 IC₅₀s of 19.40 nM and 18.42 nM, respectively. TK4b can be used for the research of leukemia and myelofibrosis.

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No. CAS: 2232890-81-0
Fòrmula: C₂₁H₂₂N₂O₂
Peso molecular:334.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

TK4b Chemical Structure

No. CAS: 2232890-81-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

TK4b is a dual JAK2/3 inhibitor with human JAK2 and JAK3 IC₅₀s of 19.40 nM and 18.42 nM, respectively. TK4b can be used for the research of leukemia and myelofibrosis^[1].

IC₅₀ & Target^[1]

JAK2

19.40 nM (IC₅₀)

JAK3

18.42 nM (IC₅₀)

Ver todos los productos específicos de isoformas JAK :

In Vitro

TK4b (1 μM; 1 h) potently inhibits purified JAK2 with an IC₅₀ of 19.40 nM and purified JAK3 with an IC₅₀ of 18.42 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2232890-81-0
Peso molecular 334.41
Fòrmula C₂₁H₂₂N₂O₂
SMILES

O=C1N(C2=CC=C(C)C(C)=C2)N(CC)C(C)=C1C(C3=CC=CC=C3)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Sanachai K, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega. 2022;7(37):33548-33559. Published 2022 Sep 6. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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TK4b

Ver todos los productos específicos de isoformas JAK

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

TK4b Related Classifications

HY-151259 Related Classifications