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Referencia número: HY-106137

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Tofimilast

Name: Tofimilast
Brand: MedChemExpress
SKU: HY-106137
Price: 128.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Tofimilast is an inhibitor of Phosphodiesterase 4 (PDE4) with an IC₅₀ of 0.14 μM. Tofimilast exerts its anti-inflammatory effects by inhibiting the activity of PDE4, thereby increasing intracellular levels of cAMP.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.55%
No. CAS: 185954-27-2
Fòrmula: C₁₈H₂₁N₅S
Peso molecular:339.46

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Tofimilast Chemical Structure

No. CAS: 185954-27-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- Ensayo clínico
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

PDE4

0.14 μM (IC₅₀)

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE) :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	5.2 μM Compound: 19, Tofimilast	Inhibition of human adenosine A1 receptor expressed in CHO cells Inhibition of human adenosine A1 receptor expressed in CHO cells	[PMID: 17228876]
Monocyte	IC₅₀	59 nM Compound: 19, Tofimilast	Inhibition of LPS-stimulated TNF alpha release in human monocytes Inhibition of LPS-stimulated TNF alpha release in human monocytes	[PMID: 17228876]
Monocyte	IC₅₀	67 nM Compound: 19, Tofimilast	Inhibition of PDE-mediated cAMP catabolism in human monocytes Inhibition of PDE-mediated cAMP catabolism in human monocytes	[PMID: 17228876]
U-937	EC₅₀	230 nM Compound: 19, Tofimilast	Increase in cAMP levels in PGE1-stimulated U937 cells Increase in cAMP levels in PGE1-stimulated U937 cells	[PMID: 17228876]

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 185954-27-2
Appearance Solid
Peso molecular 339.46
Fòrmula C₁₈H₂₁N₅S
SMILES

CCC1=NN(C2=C1CCN3C2=NN=C3C4=CC=CS4)C5CCCC5
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Duplantier AJ, et al. SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase. J Med Chem. 2007 Jan 25;50(2):344-9. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Ensayo clínico
Chemical Information
Pureza y Documentación
Referencias

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Tofimilast

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE)