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Referencia número: HY-185893

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UNC11676A

UNC11676A is an MDA5 ATPase inhibitor with IC₅₀ values of 6 μM, 115 μM and 108 μM against MDA5, LGP2 and DDX1, respectively. MDA5, LGP2 and DDX1 are three human DExD/H-box RNA helicases. UNC11676A can be used in the research of Aicardi-Goutières syndrome, Singleton-Merten syndrome, systemic lupus erythematosus and Alzheimer's disease.

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No. CAS: 3126213-85-9
Fòrmula: C₂₃H₁₇F₃N₄O₄S₂
Peso molecular:534.53

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

UNC11676A Chemical Structure

No. CAS: 3126213-85-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

Helicase

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

In Vitro

UNC11676A potently and selectively inhibits truncated human MDA5ΔCARD ATPase activity (IC₅₀ = 6 μM), with 18-fold lower potency against full-length human LGP2 (IC₅₀ = 115 μM) and full-length human DDX1 (IC₅₀ = 108 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3126213-85-9
Peso molecular 534.53
Fòrmula C₂₃H₁₇F₃N₄O₄S₂
SMILES

O=C(C1=CC=C(NC2=NC(C3=C(C)N=C(NC(C4=C(C(F)(F)F)C=CC=C4)=O)S3)=CS2)C=C1OC)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang X, et al. Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5. European journal of medicinal chemistry. 2026 May 05;309:118724. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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UNC11676A

Ver todos los productos específicos de isoformas DNA/RNA Synthesis