Withanone
Based on 1 publication(s) in Google Scholar
Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases.
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- Pureza: 93.06%
- No. CAS: 27570-38-3
- Fòrmula: C28H38O6
- Peso molecular:470.60
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Withanone
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Actividad biológica
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NMDA Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
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[PMID: 30776236] |
| HCT-15 | IC50 |
5.9 μM
Compound: 11
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Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay
Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay
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[PMID: 30776236] |
| SK-MEL-2 | IC50 |
6.1 μM
Compound: 11
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Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
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[PMID: 30776236] |
| SK-OV-3 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
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[PMID: 30776236] |
Withanone (5-20 μM; Neuro2a cells) treatment significantly reverses the cell death induced by NMDA in N2a cells[1].
Withanone (5-20 μM; Neuro2a cells) treatment significantly normalizes Bax and Bcl-2 levels[1].
Attenuation of NMDA-induced intracellular calcium releases by Withanone in N2a cells[1].
Withanone attenuates NMDA-induced Reactive Oxygen Species generation in N2a cells and induces attenuation of mitochondrial membrane motential loss[1].
Withanone treatment down-regulates the expression of cytochrome c[1].
Withanone treatment decteases the Malondialdehyde levels in NMDA-induced excitotoxicity[1].
Withanone shows promise in Alzheimer's disease (AD) treatment because of cognitive benefits and more importantly, mechanisms of action with respect to the fundamental pathophysiology of the disease, not limited to the inhibition of AChE, but also include the modification of Aβ processing, protection against oxidative stress and anti-inflammatory effects. Withanone (24 hours) treatment shows significant protective effect against amyloid β (Aβ) toxicity in Aβ induced toxicity in PC-12 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Neuro2a (N2a) cells
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:
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Result:Attenuated NMDA-Induced cell death in N2a cells.
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Cell Line:Neuro2a (N2a) cells
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:
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Result:Normalized NMDA-induced alterations in Bax and Bcl-2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (20-24 weeks; 320-360 g) received ICV injection of STZ[1]
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Dosage:5 mg/kg, 10 mg/kg and 20 mg/kg
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Administration:Oral administration; daily; for 21 days
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Result:Showed significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Also significantly reversed the decline in acetyl choline and Glutathione (GSH) activity.
Chemical Information
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No. CAS 27570-38-3
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Appearance Solid
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Peso molecular 470.60
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Fòrmula C28H38O6
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@]([C@H](O4)[C@H]4[C@]1(CC=CC2=O)O)([H])[C@@]5([H])[C@@](C)([C@]([C@@H]([C@@](O6)([H])CC(C)=C(C)C6=O)C)(O)CC5)CC3
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2024 Sep 26;9(1):253. PMID: 39327432
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Dar NJ, et al. Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells. Mol Neurobiol. 2017 Sep;54(7):5061-5073. [Content Brief]
[2]. Pandey A, et al. Multifunctional neuroprotective effect of Withanone, a compound from Withania somnifera roots in alleviating cognitive dysfunction. Cytokine. 2018 Feb;102:211-221. [Content Brief]
[3]. Chen X, et al. GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia. Signal Transduct Target Ther. 2024 Sep 26;9(1):253. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Withanone Related Classifications
HY-129692 Related Classifications
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