Z21115
Z21115 is an orally active inhibitor for phosphodiesterase 4 (PDE4), that inhibits PDE4D7 with IC50 of 10.5 nM. Z21115 inhibits Lipopolysaccharide (HY-D1056)-induced expression of IL-6, TNF-α and iNOS. Z21115 exhibits anti-inflammatory activity in DSS (HY-116282)-induced mouse colitis models without significant toxicity (1 g/kg).
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- No. CAS: 2958668-54-5
- Fòrmula: C20H20F2N2O4
- Peso molecular:390.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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PDE4D7 10.5 nM (IC50) |
PDE4D 65.7 nM (IC50) |
PDE4B 64.4 nM (IC50) |
Chemical Information
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No. CAS 2958668-54-5
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Peso molecular 390.38
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Fòrmula C20H20F2N2O4
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SMILES
COC1=C(OC)C=C(C2=CC=C(OC(F)F)C3=NN(C4CC4)C=C23)C=C1OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z21115 Related Classifications
HY-161936 Related Classifications
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