RACK1 - receptor for activated C kinase 1 Gene

Homo sapiens

Also known as H12.3; HLC-7; PIG21; GNB2L1; Gnb2-rs1

Gene ID: 10399 | Gene type: protein coding

About RACK1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,236,897-181,243,906 (from NCBI)

This gene has 35 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in ovary (RPKM 1262.3), lymph node (RPKM 598.8) and 25 other tissues.

Summary

Enables several functions, including cyclin binding activity; Enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of cellular protein metabolic process; and regulation of signal transduction. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and phagocytic cup. Part of IRE1-RACK1-PP2A complex. [provided by Alliance of Genome Resources, Apr 2022]

RACK1 Products(1)

mRNA	Protein	Name
NM_006098.5	NP_006089.1	receptor of activated protein C kinase 1

RACK1 Protein Structure

WD40

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

receptor of activated protein C kinase 1

cell proliferation-inducing gene 21 protein

Recombinant RACK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74606	RACK1 Protein, Human (His-MBP)	P63244 (M1-R317)	≥95%

Related Diseases

Diseases

Alias

Melanomatosis

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141891	M435-1279	Inhibitor	98.43%	Unkown
HY-N10335	Harringtonolide	Inhibitor	≥98.0%	Unkown
HY-162254	EGFR/ACK1-IN-1	Inhibitor	/	Unkown
HY-P0221B	PACAP (1-38) free acid TFA		/	Unkown
HY-P0221C	PACAP (1-38) free acid		/	Unkown
HY-P3879	Protein Kinase C (660-673)		/	Unkown
HY-RS11595	RACK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RACK1	VGNC	VGNC:102300
Bos taurus	RACK1	VGNC	VGNC:33676
Rattus norvegicus	RACK1	RGD	RGD:69229
Canis familiaris	RACK1	VGNC	VGNC:45309
Mus musculus	RACK1	MGD	MGI:101849
Macaca mulatta	RACK1	VGNC	VGNC:76581
Others	RACK1	NCBI

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