Dsp - desmoplakin Gene

Also Known as DP; rul; 2300002E22Rik; 5730453H04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109620

Summary

Predicted to enable protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Involved in several processes, including desmosome organization; intermediate filament organization; and ventricular compact myocardium morphogenesis. Acts upstream of or within several processes, including adherens junction organization; intermediate filament Cytoskeleton organization; and skin development. Located in basolateral plasma membrane; desmosome; and intercalated disc. Colocalizes with intermediate filament. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; heart; and sensory organ. Used to study Carvajal syndrome and arrhythmogenic right ventricular dysplasia 8. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; and dilated cardiomyopathy. Orthologous to human DSP (desmoplakin). [provided by Alliance of Genome Resources, Apr 2022]

Dsp Products (1)

mRNA Protein Name
NM_023842.2 NP_076331.2 desmoplakin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20093627 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adherens junction organization IMP
IMP: Inferred from mutant phenotype
11781569 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
9864371 MGI
acts upstream of or within desmosome organization IMP
IMP: Inferred from mutant phenotype
9864371 MGI
involved in desmosome organization IMP
IMP: Inferred from mutant phenotype
16917092 MGI
acts upstream of or within intermediate filament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
9864371 MGI
involved in intermediate filament organization IMP
IMP: Inferred from mutant phenotype
16917092 MGI
involved in protein localization to cell-cell junction IMP
IMP: Inferred from mutant phenotype
16917092 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
11781569 MGI
involved in ventricular compact myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
16917092 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
15479741 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12951053 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
9864371 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
27033150 MGI
located in desmosome IDA
IDA: Inferred from direct assay
14673151 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
17535849 MGI
colocalizes with intermediate filament IDA
IDA: Inferred from direct assay
16917092 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22515648 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desmoplakin

  • desmoplakin I/II

  • desmosomal cytoskeletal connector molecule

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-17638 Mizagliflozin Inhibitor 99.20% Phase 2
HY-139575 Guretolimod Agonist / Phase 2
HY-125079 DSP-2230 Inhibitor 98.12% Phase 1
HY-111419 DSP-1053 99.75% Phase 1
HY-114300 DSP-0565 Agonist / Phase 1
HY-157828 DSP-0390 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-118759 DSP Crosslinker 98.73% Unkown
HY-108652 α,β-Methylene-ATP trisodium Agonist 99.0% Unkown
HY-Y0332B Potassium dihydrogen phosphate, AR,99.5% Activator 99.7% Unkown
HY-156794 Enzomenib Inhibitor 99.88% Unkown
HY-103210 DSP-4 hydrochloride 98.0% Unkown
HY-Y0332K Potassium dihydrogen phosphate, for cell culture Activator / Unkown
HY-139575A Guretolimod hydrochloride 98.67% Unkown
HY-156794A Enzomenib enantiomer Inhibitor 98.01% Unkown
HY-111419A DSP-1053 benzenesulfonate / Unkown
HY-121602 DSP 4 free base / Unkown
HY-134440 α,β-Methylene-ATP dilithium Agonist / Unkown
HY-134440A α,β-Methylene-ATP Agonist / Unkown
HY-163728 DSP-6745 Modulator / Unkown
HY-167687 (RS)-Minesapride Agonist / Unkown
HY-17638A Mizagliflozin (sebacate) Inhibitor / Unkown
HY-RS04026 DSP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04027 DSPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W250199 Polyethylene glycol monooctyl ether / Unkown
HY-Y0332G Potassium dihydrogen phosphate, for molecular biology Activator / Unkown
HY-Y0332J Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard Activator / Unkown
HY-Y0332L Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 Activator / Unkown
HY-109065 Minesapride Agonist / Unkown
HY-118759S DSP Crosslinker-d8 / Unkown
HY-168631 Antibacterial agent 254 Inhibitor / Unkown
HY-177058 DSP30 Agonist 95.27% Unkown
HY-177375 dsP53-285 saRNA Activator / Unkown
HY-RS17087 Dsp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21329 Dspp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23531 Dsp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27848 Dspp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dsp NCBI NCBI:1832