Raf1 - v-raf-leukemia viral oncogene 1 Gene

Also Known as cRaf; Craf1; Raf-1; c-Raf; v-Raf; 6430402F14Rik; D830050J10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110157

About Raf1

Chromosome 6: 115,595,028-115,653,596 reverse strand.GRCm39:CM000999.3

This gene has 11 transcripts (splice variants), 219 orthologues, 23 paralogues and is associated with 101 phenotypes. Ubiquitous expression in CNS E14 (RPKM 5.6), whole brain E14.5 (RPKM 48.5) and 28 other tissues.

Summary

Enables small GTPase binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; gland development; and positive regulation of nitrogen compound metabolic process. Located in pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study Noonan syndrome 5. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Raf1 Products (3)

mRNA Protein Name
NM_001356334.2 NP_001343263.1 RAF proto-oncogene serine/threonine-protein kinase isoform 1
NM_029780.4 NP_084056.1 RAF proto-oncogene serine/threonine-protein kinase isoform 1
NM_001356333.2 NP_001343262.1 RAF proto-oncogene serine/threonine-protein kinase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
1322500 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14712229 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
18202127 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
16954213 MGI
Biological Process GO Annotation Evidence References Source
involved in ERBB2-ERBB3 signaling pathway IDA
IDA: Inferred from direct assay
24493648 MGI
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within cell differentiation IGI
IGI: Inferred from genetic interaction
10704835 MGI
acts upstream of or within death-inducing signaling complex assembly IMP
IMP: Inferred from mutant phenotype
16365167 MGI
acts upstream of extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: Inferred from genetic interaction
16365167 MGI
acts upstream of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
16365167 MGI
acts upstream of or within face development IGI
IGI: Inferred from genetic interaction
18952847 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
20056832 MGI
acts upstream of or within insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
21817126 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
33567274 MGI
acts upstream of or within intermediate filament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
16365167 MGI
acts upstream of or within intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
21817126 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: Inferred from genetic interaction
16365167 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
16365167 MGI
acts upstream of or within neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9852579 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21817126 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21817126 MGI
acts upstream of or within response to muscle stretch IMP
IMP: Inferred from mutant phenotype
20442316 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: Inferred from genetic interaction
23022482 MGI
acts upstream of or within thymus development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of positive effect type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
18202127 MGI
Cellular Component GO Annotation Evidence References Source
located in pseudopodium IDA
IDA: Inferred from direct assay
12821670 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Raf1 Protein Structure

RBD_CRAF

RBD_CRAF: cd17135 (54 - 130)

C1_A_C-Raf

C1_A_C-Raf: cd20870 (135 - 186)

STKc_C-Raf

STKc_C-Raf: cd14149 (335 - 617)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 648 a.a.
Protein Preferred Names Protein Names

RAF proto-oncogene serine/threonine-protein kinase

  • Craf1 transforming

  • murine sarcoma 3611 oncogene 1

  • proto-oncogene c-RAF

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12057 Vemurafenib 99.90% Yes
HY-10331 Regorafenib 99.97% Yes
HY-10201S Sorafenib-d3 99.57% Unkown
HY-10331A Regorafenib monohydrate 99.94% Yes
HY-N6670 Cefotetan 99.75% Unkown
HY-13308 Regorafenib Hydrochloride 99.58% Yes
HY-10201R Sorafenib (Standard) 99.71% Unkown
HY-10331B Regorafenib mesylate / Unkown
HY-10201AR Sorafenib tosylate (Standard) / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-159127 HRS-4642 99.74% Phase 2
HY-114491 Rineterkib Inhibitor 98.79% Phase 2
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Phase 2
HY-134813 MRTX1133 Inhibitor 99.97% Phase 1
HY-51424 PLX-4720 Inhibitor 99.90% Phase 1
HY-158107 BBO-8520 Inhibitor 99.90% Phase 1

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-11004 AZ 628 99.44% Unkown
HY-18832 AWL-II-38.3 Inhibitor 99.68% Unkown
HY-I0678 Regorafénib N-oxyde (M2) 98.15% Unkown
HY-W013411A Locostatin 99.88% Unkown
HY-122914 KRAS inhibitor-3 Inhibitor 99.87% Unkown
HY-P1039A R18 TFA 99.36% Unkown
HY-112440 HZX-02-059 Inhibitor 99.40% Unkown
HY-123673 MCP110 Inhibitor 99.82% Unkown
HY-15716 Kobe0065 99.93% Unkown
HY-115501 (E)-FOBISIN101 Inhibitor 95.63% Unkown
HY-117737A RRD-251 99.87% Unkown
HY-15717 Kobe2602 Inhibitor 98.20% Unkown
HY-181420A BBO-11818 99.77% Unkown
HY-10201S2 Sorafenib-13C,d3 98.35% Unkown
HY-177511 KRAS G12D-IN-30 Inhibitor 99.38% Unkown
HY-164365 PROTAC K-Ras Degrader-2 Degrader / Unkown
HY-134813A MRTX1133 formic Inhibitor 98.23% Unkown
HY-158107A (4R)-BBO-8520 Inhibitor / Unkown
HY-P1039 R18 / Unkown
HY-W013411 (E/Z)-Locostatin Control 99.52% Unkown
HY-10201S1 Sorafenib-d4 99.9% Unkown
HY-10201S4 Sorafenib-d3 tosylate Inhibitor / Unkown
HY-10331S1 Regorafenib-13C,d3 / Unkown
HY-12057S Vemurafenib-d5 / Unkown
HY-12057S1 Vemurafenib-d7 / Unkown
HY-161760 Ferroptosis inducer-3 Inhibitor / Unkown
HY-175870A (7R)-Eras-4001 Inhibitor / Unkown
HY-179133 HDB-1 Inhibitor 98.02% Unkown
HY-181420 (S,R,S)-BBO-11818 / Unkown
HY-182749 KRAS-IN-58 Inhibitor / Unkown
HY-183674 MEK-IN-10 / Unkown
HY-E70747 MEK5 Recombinant Human Active Protein Kinase / Unkown
HY-E70765 RAF1 YDYD Recombinant Human Active Protein Kinase / Unkown
HY-I0678S Regorafénib N-oxyde-d3 (M2) / Unkown
HY-I0678S1 Regorafénib N-oxyde (M2)-13C,d3 / Unkown
HY-N13009 MO-2097 / Unkown
HY-RS11619 RAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11620 Raf1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS11621 Raf1 Rat Pre-designed siRNA Set A / Unkown
HY-RS12020 RNASE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1126467 RAS-IN-5 Inhibitor / Unkown
HY-51424S PLX-4720-d7 Inhibitor / Unkown
HY-N15264 Azaspirene Inhibitor / Unkown
HY-RS26697 Rnase2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Raf1 NCBI NCBI:5894