2. Gene
  3. Akt1 - thymoma viral proto-oncogene 1 Gene

Akt1 - thymoma viral proto-oncogene 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Akt; PKB; Rac; LTR-akt; PKB/Akt; PKBalpha

Gene ID: 11651 | Gene type: protein coding

About Akt1

Chromosome 12: 112,620,255-112,641,318 reverse strand.GRCm39:CM001005.3

This gene has 9 transcripts (splice variants), 219 orthologues, 5 paralogues and is associated with 60 phenotypes. Ubiquitous expression in adrenal adult (RPKM 14.9), limb E14.5 (RPKM 84.5) and 28 other tissues.

Summary

This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), Insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Akt1 Products(5)

mRNA Protein Name
NM_001409450.1 NP_001396379.1 RAC-alpha serine/threonine-protein kinase isoform 3
NM_009652.4 NP_033782.1 RAC-alpha serine/threonine-protein kinase isoform 1
NM_001409449.1 NP_001396378.1 RAC-alpha serine/threonine-protein kinase isoform 1
NM_001165894.2 NP_001159366.1 RAC-alpha serine/threonine-protein kinase isoform 2
NM_001331107.2 NP_001318036.1 RAC-alpha serine/threonine-protein kinase isoform 1

Akt1 Protein Structure

PH_PKB

PH_PKB: cd01241 (3 - 110)

STKc_PKB_alpha

STKc_PKB_alpha: cd05594 (123 - 478)

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  • 480 a.a.
Protein Preferred Names Protein Names

RAC-alpha serine/threonine-protein kinase

AKT1 kinase

Akt1m protein

PKB alpha

RAC-PK-alpha

protein kinase B-alpha

proto-oncogene c-AKT

related to A and C kinases

tumor rejection antigen peptide pRLib

Related Agents

Clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Phase
HY-15186 Ipatasertib 99.88% Phase 4
HY-N0004 Oridonin Inhibitor 99.89% Phase 4
HY-15186A Ipatasertib dihydrochloride Inhibitor 99.27% Phase 4
HY-15431 Capivasertib Inhibitor 99.95% Phase 3
HY-10358 MK-2206 dihydrochloride 99.99% Phase 2
HY-19719 Miransertib Inhibitor 99.32% Phase 2
HY-15727 Afuresertib Inhibitor 99.54% Phase 2
HY-15965 Uprosertib Inhibitor 99.74% Phase 2
HY-19934A Pifusertib hydrochloride 98.96% Phase 2
HY-15727A Afuresertib hydrochloride Inhibitor 99.03% Phase 2
HY-19719A Miransertib hydrochloride Inhibitor 99.74% Phase 2
HY-19934 Pifusertib / Phase 2
HY-108232 MK-2206 / Phase 2
HY-15965A Uprosertib hydrochloride Inhibitor / Phase 2
HY-10249 GSK-690693 98.46% Phase 1
HY-100018 BAY1125976 Inhibitor 99.74% Phase 1
HY-16071 AT13148 Inhibitor 99.21% Phase 1
HY-100501 M2698 99.87% Phase 1
HY-137458 Vevorisertib Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (60)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18749 SC79 Activator ≥98.0% Unkown
HY-10355 AKT inhibitor VIII 98.97% Unkown
HY-107738 Guggulsterone 99.95% Unkown
HY-10425 A-443654 Inhibitor 98.50% Unkown
HY-13254 A-674563 Inhibitor 99.87% Unkown
HY-N1435 Oroxin B 99.71% Unkown
HY-11005 BX-912 99.13% Unkown
HY-137458A Vevorisertib trihydrochloride Inhibitor 99.13% Unkown
HY-12059 AT7867 Inhibitor 99.88% Unkown
HY-133120 INY-03-041 Inhibitor 98.64% Unkown
HY-18271 CaMKII-IN-1 Inhibitor 98.02% Unkown
HY-13254A A-674563 hydrochloride Inhibitor 99.86% Unkown
HY-151504 ALM301 Inhibitor 99.33% Unkown
HY-12059A AT7867 dihydrochloride Inhibitor 99.75% Unkown
HY-145282 MS170 Inhibitor 99.72% Unkown
HY-16666 3CAI Inhibitor 99.97% Unkown
HY-151613A MS15 TFA Degrader 99.86% Unkown
HY-19982 AKT-IN-6 99.51% Unkown
HY-50862 Akt1/Akt2-IN-1 Inhibitor 99.59% Unkown
HY-119016 SK1-I Inhibitor 98.47% Unkown
HY-160093 SQLE-IN-1 98.82% Unkown
HY-134903 (32-Carbonyl)-RMC-5552 Inhibitor 95.04% Unkown
HY-119016A SK1-​I hydrochloride Inhibitor 99.49% Unkown
HY-126257 AKT-IN-3 Inhibitor 99.29% Unkown
HY-151613 MS15 Inhibitor / Unkown
HY-133120A INY-03-041 trihydrochloride Inhibitor 99.27% Unkown
HY-123390 DB07107 Inhibitor / Unkown
HY-146459 Akt1-IN-1 Inhibitor 99.74% Unkown
HY-148868 Akt1&PKA-IN-1 Inhibitor / Unkown
HY-148868A Akt1&PKA-IN-2 Inhibitor / Unkown
HY-N8122 24-Methylenecycloartanyl ferulate Inhibitor 98.05% Unkown
HY-130985 9-Decyn-1-ol / Unkown
HY-145281 MS98 Inhibitor / Unkown
HY-10357 MK-2206 free base / Unkown
HY-112148 AKT-IN-2 Inhibitor / Unkown
HY-132302 Hu7691 Inhibitor / Unkown
HY-132302A Hu7691 free base Inhibitor / Unkown
HY-147935 NTQ1062 Inhibitor / Unkown
HY-107586 Demethylasterriquinone B1 Activator / Unkown
HY-129119 Akt1/Akt2-IN-2 / Unkown
HY-138767 AKT-IN-5 Inhibitor / Unkown
HY-143611 AKT-IN-8 Inhibitor / Unkown
HY-145244 APN/AKT-IN-1 Inhibitor / Unkown
HY-147937 AKT-IN-13 Inhibitor / Unkown
HY-153640 AKT-IN-14 Inhibitor / Unkown
HY-153640A AKT-IN-14 free base Inhibitor / Unkown
HY-154960 Tubulin/AKT1-IN-1 / Unkown
HY-161321 PTP1B-IN-24 / Unkown
HY-161438 Akt1-IN-3 Inhibitor / Unkown
HY-161439 Akt1-IN-4 Inhibitor / Unkown
HY-162285 Anticancer agent 189 Inhibitor / Unkown
HY-RS00542 AKT1 Human Pre-designed siRNA Set A / Unkown
HY-RS00543 Akt1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00544 Akt1 Rat Pre-designed siRNA Set A / Unkown
HY-RS00545 AKT1S1 Human Pre-designed siRNA Set A / Unkown
HY-W013816 Dipentyl phthalate 99.42% Unkown
HY-W750451 Reptoside / Unkown
HY-16032 Akt1-IN-2 Inhibitor / Unkown
HY-162102 DDR1-IN-8 Inhibitor / Unkown
HY-P5910 Azurin p28 peptide Inducer / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akt1 NCBI NCBI:207