Akt1 - thymoma viral proto-oncogene 1 Gene

Also Known as Akt; PKB; Rac; LTR-akt; PKB/Akt; PKBalpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11651

About Akt1

Chromosome 12: 112,620,255-112,641,318 reverse strand.GRCm39:CM001005.3

This gene has 9 transcripts (splice variants), 219 orthologues, 5 paralogues and is associated with 60 phenotypes. Ubiquitous expression in adrenal adult (RPKM 14.9), limb E14.5 (RPKM 84.5) and 28 other tissues.

Summary

This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), Insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as Glucose Metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Akt1 Products (5)

mRNA Protein Name
NM_001409450.1 NP_001396379.1 RAC-alpha serine/threonine-protein kinase isoform 3
NM_009652.4 NP_033782.1 RAC-alpha serine/threonine-protein kinase isoform 1
NM_001409449.1 NP_001396378.1 RAC-alpha serine/threonine-protein kinase isoform 1
NM_001165894.2 NP_001159366.1 RAC-alpha serine/threonine-protein kinase isoform 2
NM_001331107.2 NP_001318036.1 RAC-alpha serine/threonine-protein kinase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables kinase activity IDA
IDA: Inferred from direct assay
23886629 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12791994 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
14730361 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
22057101 MGI
enables protein serine kinase activity IDA
IDA: Inferred from direct assay
11784871 MGI
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
10454575 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
22057101 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
10983986 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within anagen IMP
IMP: Inferred from mutant phenotype
15713628 MGI
acts upstream of or within apoptotic mitochondrial changes IDA
IDA: Inferred from direct assay
12869584 MGI
involved in behavioral response to pain IGI
IGI: Inferred from genetic interaction
31874168 MGI
acts upstream of or within cellular response to decreased oxygen levels IDA
IDA: Inferred from direct assay
24875179 MGI
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
21712384 MGI
acts upstream of or within cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: Inferred from direct assay
23610142 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
19744960 MGI
acts upstream of or within cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
17715136 MGI
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
19139280 MGI
acts upstream of or within cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
17715136 MGI
acts upstream of or within cellular response to peptide IDA
IDA: Inferred from direct assay
23793062 MGI
acts upstream of or within cellular response to prostaglandin E stimulus IDA
IDA: Inferred from direct assay
23479225 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
24349514 MGI
acts upstream of or within cellular response to vascular endothelial growth factor stimulus IDA
IDA: Inferred from direct assay
25139353 MGI
acts upstream of or within execution phase of apoptosis IDA
IDA: Inferred from direct assay
12124386 MGI
acts upstream of or within positive effect gene expression IMP
IMP: Inferred from mutant phenotype
31272455 MGI
acts upstream of or within germ cell development IDA
IDA: Inferred from direct assay
12140361 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
19897600 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
19897600 MGI
acts upstream of or within glycogen cell differentiation involved in embryonic placenta development IMP
IMP: Inferred from mutant phenotype
12783884 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
12783884 MGI
acts upstream of or within inflammatory response IDA
IDA: Inferred from direct assay
14730361 MGI
involved in inflammatory response IGI
IGI: Inferred from genetic interaction
31874168 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
20889126 MGI
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9415393 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
11784871 MGI
involved in insulin-like growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
32439763 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
12783884 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
24740015 MGI
acts upstream of or within mammalian oogenesis stage IMP
IMP: Inferred from mutant phenotype
34635817 MGI
acts upstream of or within maternal placenta development IMP
IMP: Inferred from mutant phenotype
12783884 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11282895 MGI
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
18977203 MGI
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
19933931 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
19911006 MGI
involved in negative regulation of release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
18977203 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
19208758 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
16513828 MGI
acts upstream of or within peripheral nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
20448149 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
15249583 MGI
acts upstream of or within positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
23871832 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18292230 MGI
acts upstream of or within positive regulation of organ growth IMP
IMP: Inferred from mutant phenotype
15713641 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
15937334 MGI
involved in positive regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
9415393 MGI
acts upstream of or within positive regulation of sodium ion transport IDA
IDA: Inferred from direct assay
17715136 MGI
acts upstream of or within positive regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
17715136 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18762576 MGI
acts upstream of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
15937334 MGI
acts upstream of or within protein catabolic process IDA
IDA: Inferred from direct assay
12145204 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12145204 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
20333297 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
12145204 MGI
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
18977203 MGI
acts upstream of or within regulation of myelination IMP
IMP: Inferred from mutant phenotype
24101522 MGI
acts upstream of or within regulation of neuron projection development IDA
IDA: Inferred from direct assay
21976490 MGI
involved in regulation of neuron projection development IDA
IDA: Inferred from direct assay
19778506 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
26844834 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
26844834 MGI
acts upstream of or within regulation of protein localization IDA
IDA: Inferred from direct assay
17715136 MGI
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
9415393 MGI
acts upstream of or within response to food IDA
IDA: Inferred from direct assay
16513828 MGI
involved in response to heat IGI
IGI: Inferred from genetic interaction
31874168 MGI
involved in response to hormone IDA
IDA: Inferred from direct assay
16357133 MGI
acts upstream of or within striated muscle cell differentiation IGI
IGI: Inferred from genetic interaction
18762576 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
19596798 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12124386 MGI
located in cytosol IDA
IDA: Inferred from direct assay
28930673 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26844834 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
26844834 MGI
is active in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
30504268 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
16116448 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18388859 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15775979 MGI
located in spindle IDA
IDA: Inferred from direct assay
15509711 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Akt1 Protein Structure

PH_PKB

PH_PKB: cd01241 (3 - 110)

STKc_PKB_alpha

STKc_PKB_alpha: cd05594 (123 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
Protein Preferred Names Protein Names

RAC-alpha serine/threonine-protein kinase

  • AKT1 kinase

  • Akt1m protein

  • PKB alpha

  • RAC-PK-alpha

  • protein kinase B-alpha

  • proto-oncogene c-AKT

  • related to A and C kinases

  • tumor rejection antigen peptide pRLib

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-B0960 Sulfabenzamide 99.68% Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P99118 Serplulimab Inducer 99.30% Unkown

Clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-15186C Ipatasertib tosylate Inhibitor / Phase 3
HY-108232 MK-2206 Inhibitor 99.72% Phase 2
HY-13787 XL-418 Inhibitor 98.09% Phase 1

Pre-clinical Phase

Bioactive Molecules (34)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-141539 SETDB1-TTD-IN-1 Activator 99.93% Unkown
HY-123037 Triadimefon Inhibitor 98.12% Unkown
HY-N7627 Regaloside C Inhibitor 99.62% Unkown
HY-133120A INY-03-041 trihydrochloride Inhibitor 99.78% Unkown
HY-173155 AKT1-IN-9 Inhibitor 99.79% Unkown
HY-N1401 20(R)-Ginsenoside Rh2 Inhibitor 99.84% Unkown
HY-123035 Gamendazole Inhibitor 99.44% Unkown
HY-129119 Akt1/Akt2-IN-2 Inhibitor 98.57% Unkown
HY-122949 Momordicine I Agonist 97.0% Unkown
HY-148868A Akt1&PKA-IN-2 Inhibitor / Unkown
HY-W073128 Perfluorotetradecanoic acid Activator 98.0% Unkown
HY-143883 MS143 Degrader 97.8% Unkown
HY-145281 MS98 Inhibitor / Unkown
HY-10357 MK-2206 free base Inhibitor / Unkown
HY-16461 Solenopsin Inhibitor / Unkown
HY-138082 Rac-ZINC4085554 / Unkown
HY-W795967 Avenanthramide B Activator / Unkown
HY-161439 Akt1-IN-4 Inhibitor / Unkown
HY-163579 Akt1-IN-7 Inhibitor / Unkown
HY-181442 CK2-TN03 Inhibitor 98.02% Unkown
HY-173122 Akt1-IN-8 Inhibitor / Unkown
HY-183273 BRD4/AKT-IN-1 Inhibitor / Unkown
HY-184487 Anticancer agent 331 / Unkown
HY-N19906 Psoralenol / Unkown
HY-175716 AKT1-IN-10 Inhibitor / Unkown
HY-N17632 Moracin G Inhibitor / Unkown
HY-178142 Multi-kinase-IN-7 Inhibitor / Unkown
HY-175848 NSC 850745 Inhibitor / Unkown
HY-184592 JAK1-IN-21 Inhibitor / Unkown
HY-163577 Akt1-IN-5 Inhibitor / Unkown
HY-163578 Akt1-IN-6 Inhibitor / Unkown
HY-184145 AKT1-IN-13 Inhibitor / Unkown
HY-181659 EGFR-IN-201 Inhibitor / Unkown
HY-16032 Akt1-IN-2 Inhibitor 99.83% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akt1 NCBI NCBI:207