Cbs - cystathionine beta-synthase Gene

Also Known as HIP4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12411

Summary

Enables cystathionine beta-synthase activity. Acts upstream of or within several processes, including alpha-amino acid metabolic process; endochondral bone morphogenesis; and regulation of JUN kinase activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; connective tissue; nervous system; sensory organ; and skeleton. Used to study homocystinuria. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Apr 2022]

Cbs Products (10)

mRNA Protein Name
NM_001271353.2 NP_001258282.1 cystathionine beta-synthase isoform 2
NM_001410012.1 NP_001396941.1 cystathionine beta-synthase isoform 1
NM_001410013.1 NP_001396942.1 cystathionine beta-synthase isoform 3
NM_144855.4 NP_659104.1 cystathionine beta-synthase isoform 1
NM_178224.4 NP_835742.1 cystathionine beta-synthase isoform 2
NM_001271353.2 NP_001258282.1 cystathionine beta-synthase isoform 2
NM_001410012.1 NP_001396941.1 cystathionine beta-synthase isoform 1
NM_001410013.1 NP_001396942.1 cystathionine beta-synthase isoform 3
NM_144855.4 NP_659104.1 cystathionine beta-synthase isoform 1
NM_178224.4 NP_835742.1 cystathionine beta-synthase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cystathionine beta-synthase activity IMP
IMP: Inferred from mutant phenotype
7878023 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel diameter maintenance IMP
IMP: Inferred from mutant phenotype
10953023 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
12433838 MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
15622513 MGI
acts upstream of or within cerebellum morphogenesis IMP
IMP: Inferred from mutant phenotype
16160063 MGI
acts upstream of or within cysteine biosynthetic process IMP
IMP: Inferred from mutant phenotype
15030387 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
15622513 MGI
acts upstream of or within homocysteine metabolic process IMP
IMP: Inferred from mutant phenotype
7878023 MGI
acts upstream of or within maternal process involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
16984962 MGI
acts upstream of or within regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
15030387 MGI
acts upstream of or within regulation of nitric oxide mediated signal transduction IMP
IMP: Inferred from mutant phenotype
10953023 MGI
acts upstream of or within response to folic acid IMP
IMP: Inferred from mutant phenotype
10993757 MGI
acts upstream of or within superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
10953023 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystathionine beta-synthase

  • beta-thionase

  • serine sulfhydrase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-Y0337 L-Cysteine 99.3% Yes
HY-W016715 L-Cysteine hydrochloride hydrate Inhibitor 98.0% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-108716 Felezonexor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15300 Skepinone-L Inhibitor 99.79% Unkown
HY-W010062 4-Chlorophenylacetic acid 99.97% Unkown
HY-12852 Diclosulam Inhibitor 98.20% Unkown
HY-131059 CBS1117 Inhibitor 99.76% Unkown
HY-RS02007 CBS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177767 EY-CBS 99.92% Unkown
HY-101556 Namirotene 99.33% Unkown
HY-121841 Cannabidiorcol Inhibitor / Unkown
HY-179433 PROTAC AR Degrader-12 / Unkown
HY-111164 CBS-3595 Inhibitor / Unkown
HY-163523 PYRIB-SO 2 Inhibitor / Unkown
HY-178466 Tubulin polymerization/P-gp-IN-1 / Unkown
HY-182579 CBS-3408 Inhibitor / Unkown
HY-P5343 p53 CBS / Unkown
HY-105983A CBS-1114 hydrochloride Inhibitor / Unkown
HY-RS17100 Cbs Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23544 Cbs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbs NCBI NCBI:875