Clk1 - CDC-like kinase 1 Gene

Also Known as STY

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12747

About Clk1

Chromosome 1: 58,449,348-58,463,225 reverse strand.GRCm39:CM000994.3

This gene has 13 transcripts (splice variants), 185 orthologues, 12 paralogues and is associated with 17 phenotypes. Broad expression in bladder adult (RPKM 71.4), limb E14.5 (RPKM 59.9) and 23 other tissues.

Summary

Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Acts upstream of or within protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; neural retina; and thyroid gland. Orthologous to human CLK1 (CDC like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Clk1 Products (1)

mRNA Protein Name
NM_001042634.2 NP_001036099.1 dual specificity protein kinase CLK1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18284575 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
1825055 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
1825055 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
1825055 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
1986248 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
1825055 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
1825055 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9307018 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Clk1 Protein Structure

PKc_CLK1_4

PKc_CLK1_4: cd14213 (146 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 483 a.a.
Protein Preferred Names Protein Names

dual specificity protein kinase CLK1

  • protein kinase STY

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15338 TG003 Inhibitor 99.57% Unkown
HY-115470 CLK-IN-T3 Inhibitor 99.78% Unkown
HY-112296 T025 99.64% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-103082 CLK1-IN-1 Inhibitor 98.55% Unkown
HY-152219 CLK1-IN-2 Inhibitor 98.15% Unkown
HY-12828 KH-CB19 Inhibitor 99.31% Unkown
HY-103647 K00546 Inhibitor 99.48% Unkown
HY-155723 Leucettinib-92 Inhibitor 98.54% Unkown
HY-153708 SGC-CLK-1 Inhibitor 99.12% Unkown
HY-146221 Dyrk1A-IN-5 Inhibitor 98.06% Unkown
HY-123600 SRI-29329 Inhibitor 99.14% Unkown
HY-125290 MU1210 Inhibitor 99.50% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-149262 CLK1-IN-3 98.54% Unkown
HY-P10100 RS Repeat peptide 98.89% Unkown
HY-122631 TG693 99.95% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-131978 DB18 Inhibitor 99.15% Unkown
HY-113825 CLK1/2-IN-1 Inhibitor 99.87% Unkown
HY-400528 CLK1-IN-4 Inhibitor 99.75% Unkown
HY-15338A (E/Z)-TG003 Inhibitor 99.9% Unkown
HY-179177 AO-365/43472821 Inhibitor 99.94% Unkown
HY-183068 AP4-43 Inhibitor 99.76% Unkown
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-113670 CLK1/2-IN-2 Inhibitor 99.31% Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-125202 KuWal151 Inhibitor / Unkown
HY-146335 CLK1/4-IN-1 Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-176884 CDD-2110 Inhibitor / Unkown
HY-176885 CDD-2211 Inhibitor / Unkown
HY-176885A CDD-2212 Inhibitor / Unkown
HY-177416 MU1787 Inhibitor 99.84% Unkown
HY-182238 HPK1-IN-69 / Unkown
HY-182957 MNK/PIM-IN-2 / Unkown
HY-183831 GPS167 / Unkown
HY-184276 CLK1-IN-5 Inhibitor / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-E70691 CLK1 Recombinant Human Active Protein Kinase / Unkown
HY-N17356 Atalaphyllidine Inhibitor / Unkown
HY-RS02353 CDK11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02814 CLK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02815 Clk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02816 Clk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03004 COLEC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03043 COQ7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W409652 CLK1/4-IN-2 Inhibitor / Unkown
HY-RS18468 Coq7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18721 Colec11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clk1 NCBI NCBI:1195