Epo - erythropoietin Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13856

Summary

This gene encodes the glycoprotein hormone erythropoietin that regulates the production of red blood cells and biosynthesis of Hemoglobin. The predominant expression of this gene shifts from the liver during fetal development to kidney in adults. A complete lack of the encoded protein causes embryonic lethal anemia in mice. The conditional inactivation of this gene in adult mice results in a chronic, normocytic and normochromic anemia. Transgenic mice expressing the human ortholog of this gene exhibit polycythemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Epo Products (2)

mRNA	Protein	Name
NM_001312875.1	NP_001299804.1	erythropoietin isoform 2 precursor
NM_007942.2	NP_031968.1	erythropoietin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	21095239	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	17300687	MGI
acts upstream of or within embryo implantation	IDA IDA: Inferred from direct assay	17300687	MGI
acts upstream of or within erythrocyte differentiation	IDA IDA: Inferred from direct assay	15591122	MGI
acts upstream of or within hemoglobin biosynthetic process	IDA IDA: Inferred from direct assay	17300687	MGI
acts upstream of myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	17981124	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	21095239	MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	17981124	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21095239	MGI
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	21095239	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17300687	MGI
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	15016652	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15016652	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
erythropoietin

Recombinant Epo Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70409	Erythropoietin/EPO Protein, Mouse (HEK293, His)	Q0VED9 (A27-R192)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73038	Erythropoietin/EPO Protein, Mouse (HEK293, solution)	NP_031968.1 (A27-R192)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12654	Molidustat	Inhibitor	99.70%	Phase 3
HY-17029	Epothilone B		99.91%	Phase 3
HY-P0168A	Cibinetide acetate	Agonist	/	Phase 2
HY-163839	DS-1093a	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145405	C12-200		99.91%	Unkown
HY-P0168	Cibinetide	Agonist	99.86%	Unkown
HY-112144	TP0463518	Inhibitor	99.25%	Unkown
HY-13503	Epothilone A		99.81%	Unkown
HY-W040203	Decyl β-D-maltopyranoside		99.94%	Unkown
HY-112624K	Dextran T5 (MW 5,000)		/	Unkown
HY-W062700	STS-E412	Activator	99.72%	Unkown
HY-141625	TRC160334	Inhibitor	98.22%	Unkown
HY-141625A	TRC160334 sodium	Inhibitor	/	Unkown
HY-155009	PHD2-IN-1	Inhibitor	/	Unkown
HY-156526	PHD-IN-1	Inhibitor	/	Unkown
HY-161660	DS44470011	Inhibitor	/	Unkown
HY-162438	PHD2-IN-2	Inhibitor	/	Unkown
HY-177271	PHD2-IN-6	Inhibitor	/	Unkown
HY-179647	ZG-2686	Agonist	/	Unkown
HY-183583	HIF-2α-IN-18	Inhibitor	/	Unkown
HY-RS04446	EPO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04459	EPX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14538	TIMP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W747868	Molidustat sodium	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-172335	C9-200		/	Unkown
HY-174495	Human EPO mRNA		/	Unkown
HY-RS16566	Epo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22999	Epo Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991881	KY1070		/	Unkown
HY-108864	Epoetin alfa	Agonist	/	Unkown
HY-P991976	Anti-EPO Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epo	NCBI	NCBI:2056