Pcna - proliferating cell nuclear antigen Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18538

Summary

Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in nuclear lamina and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; brain; forelimb; heart; and sensory organ. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]

Pcna Products (1)

mRNA Protein Name
NM_011045.2 NP_035175.1 proliferating cell nuclear antigen

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
24115439 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10888872 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
19023449 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within base-excision repair, gap-filling IDA
IDA: Inferred from direct assay
15177179 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
24726645 MGI
involved in mitotic telomere maintenance via semi-conservative replication IGI
IGI: Inferred from genetic interaction
24115439 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19023449 MGI
involved in replication fork processing IGI
IGI: Inferred from genetic interaction
24115439 MGI
Cellular Component GO Annotation Evidence References Source
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
12970760 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
16489008 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
12638230 MGI
located in nuclear lamina IDA
IDA: Inferred from direct assay
10888872 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10079221 MGI
located in replication fork IDA
IDA: Inferred from direct assay
11934988 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proliferating cell nuclear antigen

  • cyclin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0095 (S)-10-Hydroxycamptothecin 99.74% Phase 2
HY-160700 TNG348 Inhibitor 99.74% Phase 2

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0692 Schisandrol B 99.92% Unkown
HY-NP199 Bovine pituitary extract Modulator / Unkown
HY-110111 T2AA 99.04% Unkown
HY-P4322 H-Ile-Lys-Val-Ala-Val-OH Activator 99.35% Unkown
HY-120836 AOH1160 98.56% Unkown
HY-153365 I-138 Inhibitor 99.75% Unkown
HY-17522 Meptyldinocap 99.91% Unkown
HY-124012 PCNA-I1 98.78% Unkown
HY-B1866 Linuron Antagonist 99.88% Unkown
HY-13338 Mabuterol Agonist 99.96% Unkown
HY-200129 PCNA-IN-1 Inhibitor 98.30% Unkown
HY-125576 Griselimycin Inhibitor 98.3% Unkown
HY-117171 Proquinazid / Unkown
HY-123715 Anticancer agent 255 / Unkown
HY-163691 Antitumor agent-163 Inhibitor / Unkown
HY-180216 USP1-IN-15 Inhibitor / Unkown
HY-180585 LOXL2/sGC modulator-2 / Unkown
HY-183363 USP1-IN-17 Inhibitor / Unkown
HY-183488 R9-caPep / Unkown
HY-183581 USP1-IN-18 Inhibitor / Unkown
HY-184385 PI3K/AKT/JAK2-IN-1 Inhibitor / Unkown
HY-P10825 p21PBP Inhibitor / Unkown
HY-RS10159 PCNA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-110111A T2AA hydrochloride Inhibitor / Unkown
HY-117846 MLAF50 Agonist / Unkown
HY-152051S Mabuterol-d9 hydrochloride Agonist / Unkown
HY-RS16672 Pcna Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23107 Pcna Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W755295 Mabuterol hydrochloride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcna NCBI NCBI:5111