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Pten - phosphatase and tensin homolog Gene

Also Known as TEP1; MMAC1; PTENbeta; 2310035O07Rik; A130070J02Rik; B430203M17Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19211

About Pten

Chromosome 19: 32,734,897-32,803,560 forward strand.GRCm39:CM001012.3

This gene has 3 transcripts (splice variants), 139 orthologues, 5 paralogues and is associated with 117 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 14.6), cortex adult (RPKM 12.9) and 28 other tissues.

Summary

This gene encodes a Phosphatase with dual activity against Phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type Phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine Phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]

Pten Products (1)

mRNA	Protein	Name
NM_008960.2	NP_032986.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IDA IDA: Inferred from direct assay	9778245	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16456542	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20940307	MGI
enables ubiquitin ligase activator activity	IMP IMP: Inferred from mutant phenotype	21241890	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of B cell proliferation	IMP IMP: Inferred from mutant phenotype	16027169	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	16027169	MGI
involved in adult behavior	IMP IMP: Inferred from mutant phenotype	16675393	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	16107612	MGI
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	20418913	MGI
involved in brain morphogenesis	IMP IMP: Inferred from mutant phenotype	19208814	MGI
acts upstream of or within cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	16107612	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	12091320	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16027168	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16027169	MGI
acts upstream of or within cellular response to decreased oxygen levels	IDA IDA: Inferred from direct assay	24875179	MGI
acts upstream of or within cellular response to hypoxia	IDA IDA: Inferred from direct assay	24875179	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	12091320	MGI
involved in central nervous system myelin maintenance	IMP IMP: Inferred from mutant phenotype	18082964	MGI
involved in central nervous system neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	18082964	MGI
involved in dentate gyrus development	IMP IMP: Inferred from mutant phenotype	17706614	MGI
acts upstream of or within endothelial cell migration	IMP IMP: Inferred from mutant phenotype	16107612	MGI
involved in forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	16675393	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	20418913	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15755804	MGI
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	17706614	MGI
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	18082964	MGI
involved in male mating behavior	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in maternal behavior	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in multicellular organismal response to stress	IMP IMP: Inferred from mutant phenotype	16675393	MGI
acts upstream of myelination	IMP IMP: Inferred from mutant phenotype	20448149	MGI
acts upstream of or within negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	16027169	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	16027169	MGI
acts upstream of or within negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	29057879	MGI
acts upstream of or within negative regulation of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	29057879	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10339565	MGI
involved in negative regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	26203138	MGI
involved in negative regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in negative regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	23575307	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	16027168	MGI
involved in negative regulation of cell size	IMP IMP: Inferred from mutant phenotype	21411674	MGI
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	21241890	MGI
involved in negative regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	16675393	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15994948	MGI
involved in negative regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21411674	MGI
acts upstream of or within negative regulation of myelination	IMP IMP: Inferred from mutant phenotype	20448149	MGI
involved in negative regulation of organ growth	IMP IMP: Inferred from mutant phenotype	19208814	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	20448149	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	10339565	MGI
acts upstream of or within negative regulation of protein kinase activity by regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	20418913	MGI
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19147652	MGI
involved in negative regulation of ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	18082964	MGI
involved in negative regulation of synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in neuron-neuron synaptic transmission	IMP IMP: Inferred from mutant phenotype	18082964	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	20448149	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	25512490	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	9778245	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21241890	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	18082964	MGI
involved in postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	18082964	MGI
involved in prepulse inhibition	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in presynaptic membrane assembly	IMP IMP: Inferred from mutant phenotype	18082964	MGI
acts upstream of or within prostate gland growth	IMP IMP: Inferred from mutant phenotype	15994948	MGI
acts upstream of or within regulation of B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9990064	MGI
acts upstream of or within regulation of axon regeneration	IGI IGI: Inferred from genetic interaction	24733831	MGI
acts upstream of or within regulation of cell cycle	IGI IGI: Inferred from genetic interaction	18332125	MGI
involved in regulation of cellular component size	IMP IMP: Inferred from mutant phenotype	18082964	MGI
involved in regulation of cellular localization	IMP IMP: Inferred from mutant phenotype	21266327	MGI
acts upstream of or within regulation of macrophage apoptotic process	IMP IMP: Inferred from mutant phenotype	9990064	MGI
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	19778506	MGI
acts upstream of or within regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	24875179	MGI
involved in rhythmic synaptic transmission	IMP IMP: Inferred from mutant phenotype	17706614	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	16675393	MGI
involved in synapse maturation	IMP IMP: Inferred from mutant phenotype	18082964	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	20237282	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14522255	MGI
located in myelin sheath adaxonal region	IDA IDA: Inferred from direct assay	20237282	MGI
is active in neuron projection	IDA IDA: Inferred from direct assay	21664258	MGI
located in neuron projection	IMP IMP: Inferred from mutant phenotype	21664258	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14522255	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pten Protein Structure

PTP_PTEN

PTEN_C2

0
100
200
300
403 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	PTENepsilon mitochondrial PTENalpha mutated in multiple advanced cancers 1

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128932	Cefminox sodium		99.83%	Unkown

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18234A	Leupeptin hemisulfate	Inhibitor	99.39%	Yes
HY-13074	VO-Ohpic trihydrate	Inhibitor	/	Unkown
HY-128693	BpV(HOpic)	Inhibitor	≥98.0%	Unkown
HY-15842	SF1670	Inhibitor	98.57%	Unkown
HY-N1435	Oroxin B	Activator	99.39%	Unkown
HY-N0103	Sophocarpine	Activator	99.85%	Unkown
HY-N1441	Afzelin		99.62%	Unkown
HY-160093	SQLE-IN-1	Inducer	99.21%	Unkown
HY-136065	bpV(phen)	Inhibitor	98.0%	Unkown
HY-N2116	Ginkgolic acid C17:1	Inhibitor	99.80%	Unkown
HY-144707	AK-778-XXMU	Agonist	99.96%	Unkown
HY-122818	BpV(phen) trihydrate	Inhibitor	98.0%	Unkown
HY-106263B	Tyroserleutide hydrochloride	Activator	99.92%	Unkown
HY-18764	BpV(pic) potassium hydrate	Inhibitor	98.8%	Unkown
HY-N2993	Polyporenic acid C	Activator	≥99.0%	Unkown
HY-170791	CIB-L43	Activator	99.71%	Unkown
HY-18234C	Leupeptin Ac-LL hydrochloride	Inhibitor	95.0%	Unkown
HY-N11709	Theasaponin E1	Activator	99.08%	Unkown
HY-N8884	Coelonin	Inhibitor	98.0%	Unkown
HY-N7325	Valerosidate	Inducer	96%	Unkown
HY-18234	Leupeptin	Inhibitor	/	Unkown
HY-178360	NP1192		/	Unkown
HY-181097	EGFR-IN-192	Modulator	/	Unkown
HY-179498	ROCK2-IN-13	Activator	/	Unkown
HY-110067	VO-OHPic	Inhibitor	/	Unkown
HY-167843	Alborixin		/	Unkown
HY-18234B	Leupeptin Ac-LL	Inhibitor	/	Unkown
HY-131549A	bpV(bipy) hydrate	Inhibitor	/	Unkown
HY-183478	Leupeptin hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pten	NCBI	NCBI:5728