Rad51 - RAD51 recombinase Gene

Also Known as Reca; Rad51a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19361

About Rad51

Chromosome 2: 118,943,274-118,977,926 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 220 orthologues, 6 paralogues and is associated with 11 phenotypes. Biased expression in placenta adult (RPKM 14.2), liver E14 (RPKM 13.5) and 13 other tissues.

Summary

Enables chromatin binding activity and single-stranded DNA binding activity. Involved in telomere maintenance via recombination and telomere maintenance via telomere lengthening. Acts upstream of or within several processes, including DNA metabolic process; cellular response to hydroxyurea; and chromosome organization. Located in chromosome, telomeric region; cytoplasm; and lateral element. Is expressed in several structures, including brain; compacted morula; gonad; hemolymphoid system; and paravertebral ganglion. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian Cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Apr 2022]

Rad51 Products (1)

mRNA Protein Name
NM_011234.5 NP_035364.1 DNA repair protein RAD51 homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA strand exchange activity IDA
IDA: Inferred from direct assay
15834424 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24108124 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9126738 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
22778135 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to alkaloid IMP
IMP: Inferred from mutant phenotype
22778135 MGI
acts upstream of or within cellular response to hydroxyurea IMP
IMP: Inferred from mutant phenotype
22778135 MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle IMP
IMP: Inferred from mutant phenotype
22778135 MGI
involved in double-strand break repair involved in meiotic recombination IDA
IDA: Inferred from direct assay
15834424 MGI
acts upstream of or within double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
15359272 MGI
involved in double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
15834424 MGI
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
15485900 MGI
acts upstream of or within meiotic cell cycle IDA
IDA: Inferred from direct assay
10809667 MGI
involved in reciprocal meiotic recombination IDA
IDA: Inferred from direct assay
15834424 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22778135 MGI
acts upstream of or within replication fork processing IMP
IMP: Inferred from mutant phenotype
22778135 MGI
acts upstream of or within replication-born double-strand break repair via sister chromatid exchange IMP
IMP: Inferred from mutant phenotype
22778135 MGI
involved in telomere maintenance via recombination IGI
IGI: Inferred from genetic interaction
21076401 MGI
involved in telomere maintenance via telomere lengthening IGI
IGI: Inferred from genetic interaction
21076401 MGI
acts upstream of or within telomere organization IMP
IMP: Inferred from mutant phenotype
22778135 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
30272023 MGI
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
21076401 MGI
located in condensed chromosome IDA
IDA: Inferred from direct assay
10809667 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
14668445 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
29955025 MGI
located in lateral element IDA
IDA: Inferred from direct assay
18694567 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
23133398 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8816780 MGI
is active in site of double-strand break IDA
IDA: Inferred from direct assay
30760716 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rad51 Protein Structure

recomb_RAD51

recomb_RAD51: TIGR02239 (24 - 338)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

DNA repair protein RAD51 homolog 1

  • RAD51 homolog A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-19793 RS-1 Activator 99.77% Phase 2
HY-111887 Emzadirib Inhibitor 99.32% Phase 2
HY-10206 Amuvatinib Inhibitor 99.40% Phase 2
HY-10206A Amuvatinib hydrochloride Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (37)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0086 DIDS sodium salt Inhibitor 99.13% Unkown
HY-101462 RAD51 Inhibitor B02 Inhibitor 99.89% Unkown
HY-15317 RI-1 Inhibitor 99.83% Unkown
HY-103710 IBR2 Inhibitor 98.24% Unkown
HY-150147 CAM833 Inhibitor 99.83% Unkown
HY-126020 Bractoppin Inhibitor 99.90% Unkown
HY-N3980 Guaiol 99.67% Unkown
HY-N7271 Solanidine Inhibitor 99.90% Unkown
HY-163944 LL-K12-18 Modulator 98.42% Unkown
HY-16904 RI-2 Inhibitor 99.90% Unkown
HY-148183 Homologous recombination-IN-1 Inhibitor 98.65% Unkown
HY-126972A RI(dl)-2 TFA Inhibitor 98.8% Unkown
HY-122705 RAD51-IN-1 Inhibitor 99.18% Unkown
HY-143736 RAD51-IN-5 Inhibitor 98.87% Unkown
HY-136604 RAD51-IN-3 Inhibitor 99.60% Unkown
HY-176549 (Rac)-IBR120 Inhibitor 99.65% Unkown
HY-143735 RAD51-IN-4 Inhibitor / Unkown
HY-143741 RAD51-IN-7 Inhibitor / Unkown
HY-143737 RAD51-IN-6 Inhibitor / Unkown
HY-121693 DIDS Inhibitor / Unkown
HY-181651 SZU305 Degrader / Unkown
HY-169213 LN-439A Inhibitor / Unkown
HY-150958 RAD51-IN-8 / Unkown
HY-P10516 BRC4 peptide / Unkown
HY-122583 D-G23 Inhibitor / Unkown
HY-178022 HDAC6-IN-63 Inhibitor / Unkown
HY-181694 SeSA-HCPT Inhibitor / Unkown
HY-N7271R Solanidine (Standard) Inhibitor / Unkown
HY-178021 HDAC1-IN-11 Inhibitor / Unkown
HY-173345 BRCA2-RAD51-IN-2 Inhibitor / Unkown
HY-103710A (R)-IBR2 Control / Unkown
HY-170907 HDAC-IN-85 Inducer / Unkown
HY-126972 RI(dl)-2 Inhibitor / Unkown
HY-162104 BRCA2-RAD51-IN-1 Inhibitor / Unkown
HY-181561 BRCA2-RAD51-IN-3 Inhibitor / Unkown
HY-169622 RAD51-IN-9 Inhibitor / Unkown
HY-172252 CSN5-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rad51 NCBI NCBI:5888