Cxcl12 - chemokine (C-X-C motif) ligand 12 Gene

Also Known as Pbsf; Sdf1; Tlsf; Tpar1; Scyb12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20315

Summary

This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Cxcl12 Products (3)

mRNA Protein Name
NM_001012477.2 NP_001012495.1 stromal cell-derived factor 1 isoform gamma precursor
NM_013655.4 NP_038683.1 stromal cell-derived factor 1 isoform beta precursor
NM_021704.3 NP_068350.1 stromal cell-derived factor 1 isoform alpha precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
12183377 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell proliferation IMP
IMP: Inferred from mutant phenotype
12707343 MGI
acts upstream of or within ameboidal-type cell migration IMP
IMP: Inferred from mutant phenotype
15626744 MGI
acts upstream of or within blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
15626744 MGI
acts upstream of or within brain development IDA
IDA: Inferred from direct assay
12183377 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15626744 MGI
acts upstream of or within cell-cell adhesion IDA
IDA: Inferred from direct assay
20847314 MGI
involved in dopaminergic neuron differentiation IDA
IDA: Inferred from direct assay
22535492 MGI
acts upstream of or within germ cell development IDA
IDA: Inferred from direct assay
12900445 MGI
acts upstream of or within germ cell migration IDA
IDA: Inferred from direct assay
12900445 MGI
acts upstream of or within induction of positive chemotaxis IDA
IDA: Inferred from direct assay
12900445 MGI
acts upstream of or within motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
16129397 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
22956548 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
22956548 MGI
acts upstream of or within positive regulation of calcium ion import IDA
IDA: Inferred from direct assay
8962122 MGI
acts upstream of or within positive regulation of cell migration IDA
IDA: Inferred from direct assay
12900445 MGI
acts upstream of or within positive regulation of chemotaxis IGI
IGI: Inferred from genetic interaction
22956548 MGI
acts upstream of or within positive regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
23844157 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
22956548 MGI
acts upstream of or within regulation of cell migration IDA
IDA: Inferred from direct assay
12183377 MGI
acts upstream of or within regulation of cell migration IGI
IGI: Inferred from genetic interaction
19064997 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19008373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

stromal cell-derived factor 1

  • 12-O-tetradecanoylphorbol 13-acetate repressed protein 1

  • pre-B-cell growth-stimulating factor

  • thymic lymphoma cell-stimulating factor

Recombinant Cxcl12 Proteins

Cat. No. Product Name Accession Purity
HY-P7285 SDF-1 alpha/CXCL12 Protein, Mouse P40224-1 (K22-K89) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7403 SDF-1 alpha/CXCL12 Protein, Mouse (68a.a, CHO) P40224-1 (K22-K89) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72782 SDF-1 beta/CXCL12 Protein, Mouse P40224-2 (K22-M93) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700219AF Animal-Free SDF-1 alpha/CXCL12 Protein, Mouse (His) P40224-1 (G21-K89) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-19867A Burixafor hydrobromide Antagonist 99.70% Phase 2
HY-160041A Olaptesed pegol sodium Inhibitor 95.94% Phase 2
HY-P1103 CTCE-9908 Antagonist 99.54% Phase 2
HY-19867 Burixafor Antagonist / Phase 2
HY-142617 ACT-1004-1239 Antagonist 98.81% Phase 1
HY-13696 MSX-122 Antagonist 98.16% Phase 1
HY-P11451 Pentixather / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99272 Ulocuplumab Antagonist 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101458A IT1t dihydrochloride 99.77% Unkown
HY-139643 CXCR7 antagonist-1 Antagonist 99.85% Unkown
HY-110318 VUF11207 fumarate Agonist 99.94% Unkown
HY-108691 PF-06465469 Inhibitor 99.48% Unkown
HY-P1104A FC131 TFA 99.87% Unkown
HY-15478 WZ811 Antagonist 99.80% Unkown
HY-P10415 EPI-X4 Antagonist 98.91% Unkown
HY-15971A AMD 3465 98.24% Unkown
HY-15971 AMD 3465 hexahydrobromide 98.0% Unkown
HY-139643A CXCR7 antagonist-1 hydrochloride Antagonist 99.41% Unkown
HY-160041 Olaptesed pegol Inhibitor 95.94% Unkown
HY-N3255 Minecoside Inhibitor 99.86% Unkown
HY-123813 CCX-777 Agonist 98.47% Unkown
HY-167851 CCX662 Inhibitor 98.62% Unkown
HY-146372 CXCR4 antagonist 5 Antagonist 99.87% Unkown
HY-147978 CXCR4 antagonist 8 Antagonist 99.88% Unkown
HY-101458 IT1t / Unkown
HY-147979 CXCR4 antagonist 9 Antagonist / Unkown
HY-168095 CXCR4 antagonist 10 Inhibitor 99.27% Unkown
HY-P10973 Peptide R analogue 10 99.47% Unkown
HY-P11011A Peptide R54 acetate 99.88% Unkown
HY-P1104 FC131 / Unkown
HY-P4111 Peptide R Antagonist / Unkown
HY-W104862 4-Amino-D-phenylalanine Inhibitor 99.74% Unkown
HY-RS16524 Cxcl12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-129094 ICT5040 Antagonist / Unkown
HY-131374 TN14003 Inhibitor / Unkown
HY-139906 CXCL12 ligand 1 Agonist / Unkown
HY-146401 CXCR4 antagonist 6 Antagonist / Unkown
HY-178205 BPRCX807 / Unkown
HY-179701 NIK-IN-3 Inhibitor / Unkown
HY-182671 SRX3305 / Unkown
HY-182850 UCUF-965 Modulator / Unkown
HY-184086 Cyclazosin / Unkown
HY-P10321 HBP08 / Unkown
HY-P11011 Peptide R54 / Unkown
HY-P11019 IS4 Antagonist / Unkown
HY-P1103A CTCE-9908 TFA Antagonist / Unkown
HY-P11728 Peptide E5 / Unkown
HY-RS03386 CXCL12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-146054A (R)-CXCR4 modulator-2 / Unkown
HY-174730 Human CXCL12 mRNA / Unkown
HY-RS22955 Cxcl12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991795 Anti-Mouse/Human CXCL12 Antibody (K15C) Inhibitor 99.57% Unkown
HY-P990390 Anti-CXCL12/SDF1a Antibody ≥99.0% Unkown
HY-P991744 Anti-Mouse CXCR4 Antibody (Cx4Mab-1) / Unkown
HY-P991790 Anti-Human/Monkey CXCR4 Antibody (12G5) Inhibitor / Unkown
HY-P992439 PF-06747143 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl12 NCBI NCBI:6387