CXCL12 - C-X-C motif chemokine ligand 12 Gene
Also Known as IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
Species: Homo sapiens
About CXCL12
This gene has 8 transcripts (splice variants), 268 orthologues and is associated with 1 phenotype. Broad expression in endometrium (RPKM 50.4), spleen (RPKM 44.2) and 23 other tissues.
Summary
This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
CXCL12 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_000609.7 | NP_000600.1 | stromal cell-derived factor 1 isoform beta precursor |
| NM_001033886.2 | NP_001029058.1 | stromal cell-derived factor 1 isoform gamma precursor |
| NM_001178134.2 | NP_001171605.1 | stromal cell-derived factor 1 isoform delta precursor |
| NM_001277990.2 | NP_001264919.1 | stromal cell-derived factor 1 isoform 5 precursor |
| NM_199168.4 | NP_954637.1 | stromal cell-derived factor 1 isoform alpha precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables CXCR chemokine receptor binding |
IDA
IDA: Inferred from direct assay
|
20388803 | GOA |
| enables chemokine activity |
IDA
IDA: Inferred from direct assay
|
18308860 | GOA |
| enables chemokine activity |
IMP
IMP: Inferred from mutant phenotype
|
27400149 | GOA |
| enables chemokine receptor binding |
IMP
IMP: Inferred from mutant phenotype
|
22457824 | GOA |
| enables integrin binding |
IDA
IDA: Inferred from direct assay
|
29301984 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
28381538 | GOA |
CXCL12 Protein Structure
IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (29 - 85)
- 0
- 93 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
stromal cell-derived factor 1 |
|
CXCL12 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CXCL12 | P48061 | XCL1 | Homo sapiens | P47992 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | XCL2 | Homo sapiens | Q9UBD3 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | P13501-PRO_0000005175 | Homo sapiens | P13501-PRO_0000005175 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | PF4V1 | Homo sapiens | P10720 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | PF4 | Homo sapiens | P02776 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | PF4 | Homo sapiens | P02776 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | CCL5 | Homo sapiens | P13501 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | CCL5 | Homo sapiens | P13501 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | CXCL11 | Homo sapiens | O14625 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | CCL25 | Homo sapiens | O15444 | 28381538 | |
|
Intra
|
CXCL12 | P48061 | CXCL6 | Homo sapiens | P80162 | 28381538 |
Recombinant CXCL12 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7287 | SDF-1 beta/CXCL12 Protein, Human (72a.a) | P48061-1 (K22-M93) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70469 | SDF-1 alpha/CXCL12 Protein, Human | P48061-2 (K22-K89) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73411 | SDF-1 beta/CXCL12 Protein, Human (HEK293, Fc) | P48061-1 (K22-M93) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73661 | SDF-1 alpha/CXCL12 Protein, Human (His) | P48061-2 (K22-K89) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700043AF | Animal-Free SDF-1 alpha/CXCL12 Protein, Human (His) | P48061-2 (V24-N88) | ≥ 95%, as determined by reducing SDS-PAGE. |
CXCL12 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811332 | CXCL12 Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P83443 | SDF1 Antibody (YA3188) | WB, ICC/IF | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Human Immunodeficiency Virus Type 1 |
|
|
| Ischemia |
|
|
| Whim Syndrome 1 |
|
|
| Molluscum Contagiosum |
|
|
| Bursitis |
|
|
| Aids Dementia Complex |
|
|
| Intraocular Lymphoma |
|
|
| Myocardial Infarction |
|
|
| Pulpitis |
|
|
| Macroglobulinemia |
|
|
| Cervical Adenocarcinoma |
|
|
| Pertussis |
|
|
| Macular Retinal Edema |
|
|
| Corneal Neovascularization |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Pelvic Inflammatory Disease |
|
|
| Cytomegalovirus Retinitis |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Retinal Vein Occlusion |
|
|
| Immune Deficiency Disease |
|
|
| Coronary Stenosis |
|
|
| Wiskott-Aldrich Syndrome |
|
|
| Adenocarcinoma |
|
|
| Microvascular Complications Of Diabetes 1 |
|
|
| Myelofibrosis |
|
|
| Polyradiculoneuropathy |
|
|
| Ocular Hypertension |
|
|
| Breast Cancer |
|
|
| Plasmacytoma |
|
|
| Glioma |
|
|
| Bone Disease |
|
|
| Limb Ischemia |
|
|
| Arteriosclerosis |
|
|
| Interstitial Lung Disease 2 |
|
|
| Migraine With Aura |
|
|
| Hematologic Cancer |
|
|
| Colorectal Cancer |
|
|
| Glioblastoma |
|
|
| Pancreatic Cancer |
|
|
| Rheumatoid Arthritis |
|
|
| Microvascular Complications Of Diabetes 5 |
|
|
| Endometrial Cancer |
|
|
| Hemangioma |
|
|
| Ovarian Cancer |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Multiple Sclerosis |
|
|
| Basal Cell Carcinoma |
|
|
| Prostate Cancer |
|
|
| Myeloma, Multiple |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Malaria |
|
|
| Severe Combined Immunodeficiency |
|
|
| Rhabdomyosarcoma |
|
|
| Thrombocytopenia |
|
|
| Systemic Lupus Erythematosus |
|
|
| Lung Cancer |
|
|
| Asthma |
|
|
| Hepatocellular Carcinoma |
|
|
| Gastric Cancer |
|
|
| Neuroblastoma |
|
|
| Muscular Dystrophy |
|
|
| Stroke, Ischemic |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Inflammatory Bowel Disease |
|
|
| Brain Cancer |
|
|
| Cardiovascular System Disease |
|
|
| Diabetes Mellitus |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Brittle Bone Disorder |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Leukemia, Acute Myeloid |
|
|
| Connective Tissue Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Nervous System Disease |
|
|
| Eye Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | CXCL12 | VGNC | VGNC:27848 |
| Rattus norvegicus | CXCL12 | RGD | RGD:3651 |
| Macaca mulatta | CXCL12 | VGNC | VGNC:82075 |
| Mus musculus | CXCL12 | MGD | MGI:103556 |
| Others | CXCL12 | NCBI |