Tfeb - transcription factor EB Gene

Also Known as Tcfeb; bHLHe35

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21425

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including defense response to Gram-negative bacterium; embryonic placenta development; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within lysosome organization and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut gland. Orthologous to human TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Apr 2022]

Tfeb Products (3)

mRNA Protein Name
NM_001161722.1 NP_001155194.1 transcription factor EB isoform b
NM_001161723.1 NP_001155195.1 transcription factor EB isoform b
NM_011549.3 NP_035679.3 transcription factor EB isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15994295 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16936731 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16936731 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16936731 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
16936731 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16936731 MGI
Biological Process GO Annotation Evidence References Source
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
27184844 MGI
involved in embryonic placenta development IMP
IMP: Inferred from mutant phenotype
9806910 MGI
involved in humoral immune response IMP
IMP: Inferred from mutant phenotype
16936731 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
31637311 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15994295 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
29146937 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16936731 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27184844 MGI
colocalizes with nucleus IDA
IDA: Inferred from direct assay
27184844 MGI
located in nucleus IDA
IDA: Inferred from direct assay
27184844 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15994295 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor EB

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-50876 Daporinad 99.91% Phase 2

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135825 TFEB activator 1 Inducer 99.71% Unkown
HY-E70076 Subtilisin, bacillus licheniformis / Unkown
HY-120380 FeTMPyP Inhibitor 99.98% Unkown
HY-107811 Harmol 99.81% Unkown
HY-N0059 D-Arabinose ≥99.0% Unkown
HY-136351 THZ-P1-2 Inhibitor 99.86% Unkown
HY-N2353 Arabinose 99.87% Unkown
HY-N0261 Aurantio-obtusin Inhibitor 99.39% Unkown
HY-161724 TFEB activator 2 98.84% Unkown
HY-112440 HZX-02-059 Inhibitor 99.40% Unkown
HY-N0866 20-Deoxyingenol Inducer 98.74% Unkown
HY-N0914 Ajugol 99.61% Unkown
HY-N7082 D-Arabinopyranose 99.94% Unkown
HY-N1983 Caudatin Inducer 99.95% Unkown
HY-161723 LH2-051 Inhibitor 99.85% Unkown
HY-RS14420 TFEB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008581 Estradiol 3-methyl ether Inhibitor 99.07% Unkown
HY-161725 TFEB activator 3 Inhibitor 98.94% Unkown
HY-162866 CXM102 Activator 99.36% Unkown
HY-148230 TFEB Decoy ODN sodium Inhibitor 90.24% Unkown
HY-N1983R Caudatin (Standard) Inducer 99.31% Unkown
HY-RS16580 Tfeb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107811A Harmol hydrochloride / Unkown
HY-138195 NEO212 / Unkown
HY-158060 MC2646 / Unkown
HY-169824 TRPML modulator 1 Inducer / Unkown
HY-50876A Daporinad hydrochloride / Unkown
HY-N0059R D-Arabinose (Standard) / Unkown
HY-N0059S D-Arabinose-13C / Unkown
HY-N0059S1 D-Arabinose-13C-1 / Unkown
HY-N0059S2 D-arabinose-13C-2 / Unkown
HY-N0059S3 D-Arabinose-13C-3 / Unkown
HY-N0059S4 D-Arabinose-d2 / Unkown
HY-N0059S5 D-Arabinose-d5 / Unkown
HY-N0059S6 D-Arabinose-d6 / Unkown
HY-N7082S D-Arabinopyranose-13C5 99.9% Unkown
HY-183660 F-SLOH / Unkown
HY-RS23014 Tfeb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfeb NCBI NCBI:7942