Vim - vimentin Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22352

Summary

Enables RNA binding activity. A structural constituent of Cytoskeleton and structural constituent of eye lens. Involved in intermediate filament organization and positive regulation of gene expression. Acts upstream of or within several processes, including SMAD protein signal transduction; astrocyte differentiation; and cellular response to interferon-gamma. Located in several cellular components, including cell leading edge; intermediate filament; and phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study cataract 30. Human ortholog(s) of this gene implicated in atherosclerosis; autoimmune disease (multiple); and cataract 30. Orthologous to human VIM (vimentin). [provided by Alliance of Genome Resources, Apr 2022]

Vim Products (1)

mRNA Protein Name
NM_011701.4 NP_035831.2 vimentin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IPI
IPI: Inferred from physical interaction
23239537 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11895474 MGI
enables structural constituent of cytoskeleton IMP
IMP: Inferred from mutant phenotype
12177195 MGI
enables structural constituent of eye lens IDA
IDA: Inferred from direct assay
15037121 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Bergmann glial cell differentiation IMP
IMP: Inferred from mutant phenotype
10816608 MGI
acts upstream of or within astrocyte development IGI
IGI: Inferred from genetic interaction
11487638 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within intermediate filament organization IGI
IGI: Inferred from genetic interaction
11487638 MGI
involved in intermediate filament organization IMP
IMP: Inferred from mutant phenotype
27559293 MGI
acts upstream of or within intermediate filament-based process IMP
IMP: Inferred from mutant phenotype
12177195 MGI
acts upstream of or within lens fiber cell development IDA
IDA: Inferred from direct assay
15037121 MGI
acts upstream of or within negative regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
11487638 MGI
acts upstream of neuron projection development IGI
IGI: Inferred from genetic interaction
11487638 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19420356 MGI
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
15958512 MGI
located in cell projection IDA
IDA: Inferred from direct assay
10989258 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15965470 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
2493000 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
16052496 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18178558 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vimentin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-109124A Taniborbactam hydrochloride Inhibitor 99.97% Phase 3
HY-109124 Taniborbactam Inhibitor 98.45% Phase 3
HY-148493 MK-3402 Inhibitor 98.18% Phase 1

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151424 Vimentin-IN-1 Inhibitor 99.74% Unkown
HY-124757 FiVe1 Inhibitor 99.90% Unkown
HY-143414 Metallo-β-lactamase-IN-6 Inhibitor / Unkown
HY-143415 Metallo-β-lactamase-IN-7 Inhibitor / Unkown
HY-144100 β-Lactamase-IN-7 Inhibitor / Unkown
HY-144259 Metallo-β-lactamase-IN-2 Inhibitor / Unkown
HY-144261 Metallo-β-lactamase-IN-3 Inhibitor / Unkown
HY-144262 Metallo-β-lactamase-IN-4 Inhibitor / Unkown
HY-144659 Metallo-β-lactamase-IN-5 / Unkown
HY-146165 Metallo-β-lactamase-IN-8 Inhibitor / Unkown
HY-146637 VIM-2-IN-1 Inhibitor / Unkown
HY-155201 YJ182 Inhibitor / Unkown
HY-161310 Metallo-β-lactamase-IN-15 Inhibitor / Unkown
HY-163339 Metallo-β-lactamase-IN-14 Inhibitor / Unkown
HY-168500 Metallo-β-lactamase-IN-16 Inhibitor / Unkown
HY-171112 KSP-1007 Inhibitor / Unkown
HY-174212 MXC-017 Inducer / Unkown
HY-176519 ANT2681 Inhibitor / Unkown
HY-182058 ATM potentiator-1 Inhibitor / Unkown
HY-RS15652 VIM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122711 3-Cyanochromone Inhibitor / Unkown
HY-128049 ML121 Inhibitor / Unkown
HY-152105 Metallo-β-lactamase-IN-9 Inhibitor / Unkown
HY-173472 MBL-IN-5 Inhibitor / Unkown
HY-175724 MBL-IN-6 Inhibitor / Unkown
HY-178976 YL6113 Inhibitor / Unkown
HY-B0368C epi-D-Captopril Inhibitor / Unkown
HY-RS17324 Vim Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23779 Vim Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vim NCBI NCBI:7431