Atr - ataxia telangiectasia and Rad3 related Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 245000

About Atr

Chromosome 9: 95,739,650-95,833,834 forward strand.GRCm39:CM001002.3

This gene has 13 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 67 phenotypes. Broad expression in testis adult (RPKM 8.1), CNS E11.5 (RPKM 3.4) and 21 other tissues.

Summary

Enables protein kinase activity. Involved in positive regulation of telomere maintenance via Telomerase and replication fork processing. Acts upstream of or within several processes, including DNA damage checkpoint signaling; embryo implantation; and protein phosphorylation. Located in XY body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and gonad. Used to study Seckel syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic Cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atr Products (1)

mRNA Protein Name
NM_019864.1 NP_063917.1 serine/threonine-protein kinase ATR

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15680327 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
15364958 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
12937170 MGI
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
15983387 MGI
acts upstream of or within DNA repair IDA
IDA: Inferred from direct assay
15364958 MGI
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
10691732 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
10691732 MGI
involved in positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
26586427 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15364958 MGI
acts upstream of or within regulation of protein binding IDA
IDA: Inferred from direct assay
15983387 MGI
involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
29125140 MGI
Cellular Component GO Annotation Evidence References Source
part of ATR-ATRIP complex IPI
IPI: Inferred from physical interaction
11721054 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
29279380 MGI
located in XY body IDA
IDA: Inferred from direct assay
18316482 MGI
located in chromosome IDA
IDA: Inferred from direct assay
22549958 MGI
is active in extrinsic component of synaptic vesicle membrane IDA
IDA: Inferred from direct assay
29279380 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
31839538 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
29279380 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Atr Protein Structure

UME

UME: smart00802 (1118 - 1224)

NR_LBD

NR_LBD: cl11397 (1528 - 1606)

FAT

FAT: pfam02259 (1770 - 2091)

TEL1

TEL1: cl34875 (2122 - 2640)

PIKKc_ATR

PIKKc_ATR: cd00892 (2289 - 2563)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2641 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ATR

  • ataxia telangiectasia and Rad3-related protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-19323 Ceralasertib Inhibitor 99.76% Phase 3
HY-13902 Berzosertib Inhibitor 99.67% Phase 2
HY-101566 Elimusertib Inhibitor 99.91% Phase 2
HY-139609 Camonsertib Inhibitor 99.99% Phase 2
HY-101566A Elimusertib hydrochloride Inhibitor 99.85% Phase 2

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14731 VE-821 Inhibitor 99.67% Unkown
HY-136270 Gartisertib Inhibitor 99.77% Unkown
HY-15557 AZ20 Inhibitor 99.40% Unkown
HY-15520 CGK733 Inhibitor 99.71% Unkown
HY-15521 ETP-46464 Inhibitor 99.54% Unkown
HY-N6954 Garcinone C Activator 99.51% Unkown
HY-159480 AD1058 Inhibitor 98.11% Unkown
HY-P10280 ATR kinase substrate peptide Substrate 99.30% Unkown
HY-161615 PROTAC ATR degrader-2 Degrader 99.73% Unkown
HY-13816 NU6027 Inhibitor 98.01% Unkown
HY-157767 Abd110 Inhibitor 98.67% Unkown
HY-147569 ATR-IN-17 Inhibitor / Unkown
HY-147567 ATR-IN-15 Inhibitor / Unkown
HY-147566 ATR-IN-14 Inhibitor / Unkown
HY-182017 ATR ligand 2 Ligand / Unkown
HY-13902A Berzosertib hydrochloride Inhibitor 98.77% Unkown
HY-161838 ICT10336 Inhibitor / Unkown
HY-182016 PROTAC ATR degrader-3 Degrader / Unkown
HY-151915 ATR-IN-20 Inhibitor / Unkown
HY-174828 ATR/PARP1-IN-1 Inhibitor / Unkown
HY-147568 ATR-IN-16 Inhibitor / Unkown
HY-153393 ATR-IN-21 Inhibitor / Unkown
HY-147190 ATR-IN-19 Inhibitor / Unkown
HY-144214 ATR-IN-10 Inhibitor / Unkown
HY-147570 ATR-IN-18 Inhibitor / Unkown
HY-147565 ATR-IN-13 Inhibitor / Unkown
HY-172247 ATR-IN-31 Inhibitor / Unkown
HY-153729 ATR-IN-29 Inhibitor / Unkown
HY-161616 ATR-IN-30 / Unkown
HY-141478 Antitumor agent-28 Inhibitor / Unkown
HY-N18301 Americanin A Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atr NCBI NCBI:545
Macaca fascicularis Atr NCBI NCBI:101926636
Rattus norvegicus Atr NCBI NCBI:685055
Macaca mulatta Atr NCBI NCBI:714443