Tf - transferrin Gene

Also Known as Tfn; Trf

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24825

Summary

Enables ferric iron binding activity. Involved in several processes, including cellular response to cAMP; cellular response to follicle-stimulating hormone stimulus; and regulation of nervous system development. Located in basement membrane; cell tip; and extracellular space. Used to study hepatitis. Biomarker of anemia and obesity. Human ortholog(s) of this gene implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Orthologous to human TF (transferrin). [provided by Alliance of Genome Resources, Apr 2022]

Tf Products (1)

mRNA Protein Name
NM_001013110.1 NP_001013128.1 serotransferrin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ferric iron binding IDA
IDA: Inferred from direct assay
17373738 RGD
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
17417667 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
15831523 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
15831523 RGD
involved in iron ion transport IDA
IDA: Inferred from direct assay
17373738 RGD
involved in positive regulation of myelination IDA
IDA: Inferred from direct assay
16480980 RGD
involved in positive regulation of oligodendrocyte progenitor proliferation IDA
IDA: Inferred from direct assay
23368675 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16479386 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
23007736 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16519141 RGD
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
1723977 RGD
located in cell tip IDA
IDA: Inferred from direct assay
17373738 RGD
located in dendrite IDA
IDA: Inferred from direct assay
26109571 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17350134 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serotransferrin

  • beta-1 metal-binding globulin

  • liver regeneration-related protein LRRG03

  • siderophilin

Recombinant Tf Proteins

Cat. No. Product Name Accession Purity
HY-P73454 Transferrin Protein, Rat (HEK293, His) P12346 (V20-S698) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-152963 Tisotumab vedotin 97.20% Unkown
HY-P0171 Motixafortide Antagonist 99.76% Unkown
HY-18763 Indobufen Inhibitor 99.98% Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-P5533 CRT 99.76% Phase 4
HY-19284 FR-146687 Inhibitor / Phase 2
HY-N1992 Theaflavin 3,3'-digallate Inhibitor 99.89% Phase 1
HY-153480A ARC19499 sodium Inhibitor 99.40% Phase 1
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P990090 Rademikibart Inhibitor 99.13% Phase 3
HY-P99271A Tisotumab (powder) / Phase 3
HY-P991378 MORAb-066 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100388 SHP099 Inhibitor 99.81% Unkown
HY-134094 Fluridone 99.93% Unkown
HY-N2099 Onjisaponin B Inhibitor 99.31% Unkown
HY-NP0182 Peanut Agglutinin (Biotinylated) / Unkown
HY-173444 HDAC11-IN-3 99.70% Unkown
HY-P5875A P4pal10 TFA Antagonist 98.25% Unkown
HY-116170 SN34037 Inhibitor 99.02% Unkown
HY-153480 ARC19499 Inhibitor 93.65% Unkown
HY-13496 JNJ-28312141 Inhibitor / Unkown
HY-13496A JNJ-28312141 hydrochloride Inhibitor / Unkown
HY-145743 CP-17 Inhibitor / Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.10% Unkown
HY-156158 IDH2R140Q-IN-2 Inhibitor / Unkown
HY-162490 TF-S14 Inhibitor / Unkown
HY-169335 HIV-1 inhibitor-77 Inhibitor / Unkown
HY-170723 JAK-IN-39 Inhibitor / Unkown
HY-172905 BCX-3607 / Unkown
HY-18763A Indobufen sodium Inhibitor / Unkown
HY-18763S Indobufen-d5 Inhibitor / Unkown
HY-N10310 TF-3-G-cThea / Unkown
HY-N15874 C16/C11-TF/C12-DNP TG / Unkown
HY-N2099A (Z)-Onjisaponin B / Unkown
HY-P5152 Scorpion toxin Tf2 Activator / Unkown
HY-P5875 P4pal10 Antagonist / Unkown
HY-RS04643 F3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14406 TF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174724 Human CXCR5 mRNA / Unkown
HY-N10309 TF-3ʹ-G-cThea / Unkown
HY-RS16867 F3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21604 Itpr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23170 Tf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23308 F3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99271 Tisotumab 99.90% Unkown
HY-P991619 CNTO-860 Inhibitor / Unkown
HY-P992360 GT-002 Modulator / Unkown
HY-P991989 MRG004A Antibody 95.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tf NCBI NCBI:7018