TF - transferrin Gene

Homo sapiens

Also known as TFQTL1; PRO1557; PRO2086; HEL-S-71p

Gene ID: 7018 | Gene type: protein coding

About TF

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,661,998-133,796,641 (from NCBI)

This gene has 14 transcripts (splice variants), 170 orthologues, 3 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 1622.3).

Summary

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

TF Products(3)

mRNA	Protein	Name
NM_001063.4	NP_001054.2	serotransferrin isoform 1 precursor
NM_001354703.2	NP_001341632.2	serotransferrin isoform 2
NM_001354704.2	NP_001341633.2	serotransferrin isoform 3

TF Protein Structure

Transferrin

0
200
400
600
698 a.a.

Protein Preferred Names

Protein Names

serotransferrin

beta-1 metal-binding globulin

Recombinant TF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70620	Transferrin Protein, Human (HEK293, His)	P02787/AAA61140.1/NP_001054.1 (V20-P698)	≥95%
HY-P73452	Transferrin Protein, Human (698a.a, HEK293, His)	P02787 (M1-P698)	≥95%
HY-P700267	Transferrin Protein, Human (679a.a, His)	AAA61140.1 (V20-P698)	≥95%
HY-P700648	Transferrin Protein, Human (679a.a, HEK293, C-His)	AAH59367 (V20-P698)	≥95%

Related Diseases

Diseases

Alias

Atransferrinemia

Familial Hypotransferrinemia	Congenital Atransferrinemia
Hypotransferrinemia, Familial	Congenital Hypotransferrinemia
ATRAF

Iron Overload In Africa

African Iron Overload	Bantu Siderosis
African Hemochromatosis	Hereditary Iron Overload And African Americans
African Nutritional Hemochromatosis	African Siderosis

Nutritional Deficiency Disease

Malnutrition	Nutritional Disorder
Nutritional Deficiency	Nutrition
Deficiency Diseases	Carbamoyl-Phosphate Synthase I Deficiency Disease
Nutrition Disorders

Iron Metabolism Disease

Iron Deficiency	Iron Disorder
Iron Metabolism Disorders	Disorder Of Iron Metabolism
Iron	Fe Deficiency
Iron Storage Disease	Iron Storage Disorder

Iron Deficiency Anemia

Iron-Deficiency Anemia	Fe Deficiency Anaemia
Ida - [Iron Deficiency Anemia]	Fe - [Iron] Deficiency Anemia Nos

Siderosis

Pulmonary Siderosis	Deposition Of Iron
Arc-Welders' Disease	Arc-Welders' Lung
Arc-Welders' Nodulation	Arc-Welders' Pneumoconiosis
Iron Oxide Lung	Iron Pneumoconiosis
Pneumoconiosis Siderotico	Siderotic Lung Disease
Steel Grinders' Disease	Welders' Lung
Welders' Siderosis	Lung Fibrosis With Siderosis

Protein-Energy Malnutrition

PEM	Protein Energy Malnutrition

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia

Hfe Hemochromatosis

Hemochromatosis Type 1	Hfe-Associated Hemochromatosis
Hfe-Hh

Rare Hereditary Hemochromatosis

Iron Overload	Iron Overload Disease
Idiopathic Haemosiderosis	Hemosiderosis

Beta-Thalassemia

Beta Thalassemia	Cooley'S Anemia
Mediterranean Anemia	Beta Thalassemia Intermedia
Erythroblastic Anemia	Thalassemia, Hispanic Gamma-Delta-Beta
Thalassemia Major	Thalassemia Minor
Beta-Plus-Thalassemia	Thalassemia, Beta
Beta Thalassemia Major	Beta Thalassemia Minor
Thalassemias, Beta-	Microcytemia, Beta Type
Thalassemia, Beta Type	B-THAL
Mediterranean Anaemia	Beta Thalassaemia Syndrome
Mediterranean Disease	Beta Thalassaemia Disease

Haemophilus Influenzae

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Congenital Disorder Of Glycosylation, Type Ia

CDG1A	Cdg Ia
Phosphomannomutase 2 Deficiency	Jaeken Syndrome
Pmm2-Congenital Disorder Of Glycosylation	Congenital Disorder Of Glycosylation Type Ia
Cdgia	Congenital Disorder Of Glycosylation Ia
Congenital Disorder Of Glycosylation 1a	Carbohydrate-Deficient Glycoprotein Syndrome Type Ia
Cdgs1a	Pmm2-Cdg
Cdg-Ia	Congenital Disorder Of Glycosylation Type 1a
Carbohydrate-Deficient Glycoprotein Syndrome, Type Ia, Formerly	Pmm Deficiency
Cdg Syndrome Type Ia	Carbohydrate Deficient Glycoprotein Syndrome Type Ia
Cdg Syndrome Type 1a	Jaeken'S Syndrome
Pmm2 Deficiency	Glycosylation, Congenital Disorder Of, Type Ia

Dysentery

Infectious Diarrhea

Intracranial Hypotension

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Thalassemia

Sickle-Cell Thalassemia With Crisis	Sickle-Cell Thalassemia Without Crisis
Thalassemia Hb-S Disease With Crisis	Thalassemia Hb-S Disease Without Crisis
Thalassemias	Hereditary Leptocytosis
Haemoglobin Thalassaemia Disorder	Thalassaemia Syndrome
Thalassaemia Nos	Thalassemia Variants

Porphyria Cutanea Tarda

Hepatoerythropoietic Porphyria	HEP
Uroporphyrinogen Decarboxylase Deficiency	Pct
Pct, Type Ii	Porphyria, Hepatocutaneous Type
Urod Deficiency	Porphyria, Hepatoerythropoietic
Porphyria Cutanea Tarda, Susceptibility To	Familial Porphyria Cutanea Tarda
Porphyria Cutanea Tarda, Type Ii	Pct, 'Familial' Type
Porphyria, Hepatic	FPCT
Pct Type Ii	Porphyria Cutanea Tarda Type Ii
Porphyria Hepatocutaneous Type	Heterozygous Uroporphyrinogen Decarboxylase Deficiency
Urod - [Uroporphyrinogen Decarboxylase] Deficiency	Pct - [Porphyria Cutanea Tarda]

Hemosiderosis

Haemosiderosis

Iron Overload

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Hyperferritinemia With Or Without Cataract

Hyperferritinemia-Cataract Syndrome	Hhcs
Hereditary Hyperferritinemia With Congenital Cataracts	Hyperferritinemia, Hereditary, With Congenital Cataracts
Bonneau-Beaumont Syndrome	HRFTC
Hereditary Hyperferritinemia-Cataract Syndrome	Cataract-Hyperferritinemia Syndrome
Hyperferritinemia Cataract Syndrome	Hereditary Hyperferritinemia Cataract Syndrome

Chronic Kidney Disease

Chronic Renal Disease	Chronic Kidney Failure
Ckd	Chronic Renal Failure
Kidney Failure, Chronic	Chronic Renal Failure Syndrome
Crf	Renal Failure - Chronic
Renal Failure Chronic	Chronic Kidney Diseases
Chronic Kidney Disease Stage 5	Ckd - [Chronic Kidney Disease]
Crf - [Chronic Renal Failure]	Chronic Kidney Impairment
Chronic Renal Impairment	Chronic Kidney Shutdown
Chronic Hypoxic Kidney Failure	Chronic Kidney Collapse
Chronic Renal Insufficiency	Chronic Kidney Toxaemia
Chronic Kidney Hypofunction	Chronic Renal Suppression
Chronic Renal Failure, Stage 5	Ckd - [Chronic Kidney Disease] Stage 5
End Stage Kidney Failure	End Stage Renal Failure
End Stage Kidney Disease	End Stage Renal Disease
End Stage Chronic Renal Failure	Esrf - [End Stage Renal Failure]
Esrd - [End Stage Renal Diseases]	Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Hypochromic Microcytic Anemia

Anemia, Hypochromic Microcytic

Microcytic Hypochromic Anemia

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Analbuminemia

ANALBA	Congenital Analbuminemia
Hypoalbuminemia

Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome	Ards
Non-Cardiogenic Pulmonary Edema	Acute Lung Injury
Respiratory Distress Syndrome, Adult	Shock Lung
Acute Respiratory Distress	Respiratory Distress Syndrome
Adult Rds	Ali
Increased-Permeability Pulmonary Edema	Stiff Lung
Respiratory Distress Syndrome Adult

Trypanosomiasis

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Congenital Hemolytic Anemia

Anemia Hemolytic Congenital	Anemia, Hemolytic, Congenital
Congenital Hemolytic Anaemia	Hereditary Hemolytic Anaemia
Hereditary Hemolytic Anemia

Interstitial Lung Disease

Ild	Lung Diseases, Interstitial
Lung Diseases Interstitial	Interstitial Lung Diseases

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Hemoglobinopathy

Hemoglobinopathies

Lipoid Nephrosis

Minimal Change Disease	Minimal Change Glomerulonephritis
Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis	Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome
Idiopathic Minimal Change Nephrotic Syndrome	Mcns
Minimal Change Glomerulopathy	Minimal Change Nephrotic Syndrome
Nephrotic Syndrome Minimal Change	Nephrosis, Lipoid
Glomerulonephritis, Minimal Change	Nephrotic Syndrome, Minimal Change

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Histoplasmosis

Darling Disease	Reticuloendotheliosis, X-Linked
Infection By Histoplasma Capsulatum	Histoplasma Infection
Reticuloendothelial Cytomycosis	Cytomycosis
Darling Histoplasmosis	African Histoplasmosis
Histoplasmosis Duboisii

Proctitis

Ulcerative Proctitis	Chronic Ulcerative Proctitis
Idiopathic Proctitis	Nonspecific Ulcerative Proctitis
Ulcerative Colitis Confined To Rectum	Ip - [Idiopathic Proctitis]
Chronic Ulcerative Proctitis Nos

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome	AIS
Testicular Feminization Syndrome	Androgen Receptor Deficiency
Dhtr Deficiency	Dihydrotestosterone Receptor Deficiency
Ar Deficiency	Testicular Feminization
Tfm	Androgen Insensitivity
Androgen-Insensitivity Syndrome	Goldberg-Maxwell Syndrome
Complete Androgen Insensitivity Syndrome	Cais
Feminisation - Testicular	Goldberg - Maxwell Syndrome
Androgen Insensitivity Syndrome, Complete	Morris Syndrome
Ary	AR
Insensitivity Syndrome, Androgen	Androgen Insensitivity Nos

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

Scrapie

Marasmus

Nutritional Marasmus

Nutritional Atrophy

Cystinosis

Cystine Storage Disease	Cystine Diathesis
Cystine Disease	Cystinoses
Protein Defect Of Cystin Transport	Cystin Transport, Protein Defect Of
Nephropathic Cystinosis	Protein Defect Of Cystine Transport

Diabetes Mellitus

Diabetes

Vitreoretinopathy, Neovascular Inflammatory

Proliferative Vitreoretinopathy	Adniv
Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy	VRNI
Pvr	Neovascular Inflammatory Vitreoretinopathy
Vitreoretinopathy, Neovascular Inflammatory, Autosomal Dominant	Retinitis Proliferans
Neovascular Inflammatory Vitreoretinopathy Autosomal Dominant	Vitreoretinopathy Proliferative
Vitreoretinopathy, Proliferative	Proliferative Vitreo-Retinopathy

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18763	Indobufen	Inhibitor	99.98%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0171	Motixafortide	Antagonist	99.88%	Phase 3
HY-N1992	Theaflavin 3,3'-digallate		99.73%	Phase 1
HY-153480	ARC19499	Inhibitor	93.65%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99271	Tisotumab		95.00%	Phase 3
HY-P990090	Rademikibart	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134094	Fluridone		99.79%	Unkown
HY-152963	Tisotumab vedotin		99.47%	Unkown
HY-148880	VHLL-BCN		/	Unkown
HY-153480A	ARC19499 sodium		93.65%	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.32%	Unkown
HY-156158	IDH2R140Q-IN-2	Inhibitor	/	Unkown
HY-18763S	Indobufen-d5	Inhibitor	/	Unkown
HY-N10308	TF-DG-cThea		/	Unkown
HY-N10310	TF-3-G-cThea		/	Unkown
HY-P5152	Scorpion toxin Tf2	Activator	/	Unkown
HY-RS14406	TF Human Pre-designed siRNA Set A		/	Unkown
HY-100388B	SHP099 hydrochloride	Inhibitor	/	Unkown
HY-N10309	TF-3ʹ-G-cThea		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TF	VGNC	VGNC:82716
Mus musculus	TF	MGD	MGI:98821
Rattus norvegicus	TF	RGD	RGD:3845
Canis familiaris	TF	NCBI
Macaca fascicularis	TF	NCBI
Susscrofa domestica	TF	NCBI
Leporidae	TF	NCBI
Others	TF	NCBI