TF - transferrin Gene

Also Known as TFQTL1; PRO1557; PRO2086; HEL-S-71p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7018

About TF

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,661,998-133,796,641 (from NCBI)

This gene has 14 transcripts (splice variants), 170 orthologues, 3 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 1622.3).

Summary

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

TF Products (3)

mRNA	Protein	Name
NM_001063.4	NP_001054.2	serotransferrin isoform 1 precursor
NM_001354703.2	NP_001341632.2	serotransferrin isoform 2
NM_001354704.2	NP_001341633.2	serotransferrin isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	37277838	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	18353247	GOA
enables iron chaperone activity	IDA IDA: Inferred from direct assay	18353247	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14691533	GOA
enables transferrin receptor binding	IPI IPI: Inferred from physical interaction	9546397	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	37277838	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to iron ion	IGI IGI: Inferred from genetic interaction	18353247	GOA
involved in intracellular iron ion homeostasis	IGI IGI: Inferred from genetic interaction	18353247	GOA
involved in multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	11113131	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	37277838	GOA
involved in positive regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	12704209	GOA
involved in positive regulation of receptor-mediated endocytosis	IGI IGI: Inferred from genetic interaction	18353247	GOA
involved in regulation of iron ion transport	IGI IGI: Inferred from genetic interaction	18353247	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of HFE-transferrin receptor complex	IDA IDA: Inferred from direct assay	9546397	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11208127	GOA
located in basal part of cell	IDA IDA: Inferred from direct assay	15880641	GOA
located in basal plasma membrane	IDA IDA: Inferred from direct assay	15880641	GOA
located in cell surface	IDA IDA: Inferred from direct assay	16195351	GOA
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	12857860	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12857860	GOA
located in early endosome	IDA IDA: Inferred from direct assay	15880641	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	15229288	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	9990067	GOA
located in extracellular region	IGI IGI: Inferred from genetic interaction	18353247	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	37277838	GOA
located in late endosome	IDA IDA: Inferred from direct assay	15880641	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15880641	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	15880641	GOA
located in vesicle	IDA IDA: Inferred from direct assay	18353773	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TF Protein Structure

Transferrin

0
200
400
600
698 a.a.

Protein Preferred Names	Protein Names
serotransferrin	beta-1 metal-binding globulin

TF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TF	P02787	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	TF	P02787	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	TF	P02787	RMDN3	Homo sapiens	Q96TC7	Validated Y2H	32296183
Intra	TF	P02787	RMDN3	Homo sapiens	Q96TC7	Y2H Array	32296183
Intra	TF	P02787	RMDN3	Homo sapiens	Q96TC7	Y2H Prey Pooling	32296183
Intra	TF	P02787	SORT1	Homo sapiens	Q99523	Validated Y2H	32296183
Intra	TF	P02787	SORT1	Homo sapiens	Q99523	Y2H Prey Pooling	32296183
Intra	TF	P02787	SORT1	Homo sapiens	Q99523	Y2H Array	32296183
Intra	TF	P02787	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	TF	P02787	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TF	P02787	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	TF	P02787	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	TF	P02787	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	TF	P02787	SLC26A6	Homo sapiens	Q9BXS9-3	Validated Y2H	32296183
Intra	TF	P02787	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Array	32296183
Intra	TF	P02787	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Prey Pooling	32296183
Cross	TF	P02787	tbpB	Neisseria meningitidis serogroup B	Q9K0V0	GMS	22327295
Cross	TF	P02787	tbpB	Neisseria meningitidis serogroup B	Q9K0V0	SAXS	22327295
Intra	TF	P02787	AQP9	Homo sapiens	O43315	Y2H Array	32296183
Intra	TF	P02787	AQP9	Homo sapiens	O43315	Y2H Prey Pooling	32296183
Intra	TF	P02787	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	TF	P02787	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	TF	P02787	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	TF	P02787	GJB1	Homo sapiens	P08034	Validated Y2H	32296183
Intra	TF	P02787	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	TF	P02787	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	TF	P02787	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	TF	P02787	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	TF	P02787	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	TF	P02787	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	TF	P02787	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	TF	P02787	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	TF	P02787	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	TF	P02787	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TF	P02787	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	TF	P02787	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TF	P02787	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	TF	P02787	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	TF	P02787	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	TF	P02787	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	TF	P02787	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	TF	P02787	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	TF	P02787	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	TF	P02787	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	TF	P02787	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	TF	P02787	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	TF	P02787	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	TF	P02787	GAST	Homo sapiens	P01350	Crosslink	19664057
Intra	TF	P02787	GAST	Homo sapiens	P01350	SPR	19664057
Intra	TF	P02787	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	TF	P02787	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	TF	P02787	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	TF	P02787	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TF	P02787	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TF	P02787	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TF	P02787	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
Intra	TF	P02787	SYT2	Homo sapiens	Q8N9I0	Validated Y2H	32296183
Intra	TF	P02787	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70620	Transferrin Protein, Human (HEK293, His)	P02787/AAA61140.1/NP_001054.1 (V20-P698)	≥ 95%, as determined by reducing SDS-PAGE.

TF Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85682	Transferrin Antibody (YA5374)	WB, IHC-P, ICC/IF,	Human
HY-P85749	Transferrin Antibody (YA5441)	IHC-P, ICC/IF, ELISA	Human
HY-P85751	Transferrin Antibody (YA5443)	IHC-P, ICC/IF, ELISA	Human
HY-P86735	Transferrin Antibody (YA6427)	WB, IHC-P, IHC-F, IF-Tissue, FC	Human, Rat, Mouse, Cow
HY-P86735A	Transferrin Antibody (YA6427)(PBS only)	WB, IHC-P, IHC-F, IF-Tissue, FC	Human, Rat, Mouse, Cow

Related Diseases

Diseases	Alias
Atransferrinemia	Familial Hypotransferrinemia Congenital Atransferrinemia Hypotransferrinemia, Familial Congenital Hypotransferrinemia ATRAF
Iron Overload In Africa	African Iron Overload Bantu Siderosis African Hemochromatosis Hereditary Iron Overload And African Americans African Nutritional Hemochromatosis African Siderosis
Nutritional Deficiency Disease	Malnutrition Nutritional Disorder Nutritional Deficiency Nutrition Deficiency Diseases Carbamoyl-Phosphate Synthase I Deficiency Disease Nutrition Disorders
Iron Metabolism Disease	Iron Deficiency Iron Disorder Iron Metabolism Disorders Disorder Of Iron Metabolism Iron Fe Deficiency Iron Storage Disease Iron Storage Disorder
Iron Deficiency Anemia	Iron-Deficiency Anemia Fe Deficiency Anaemia Ida - [Iron Deficiency Anemia] Fe - [Iron] Deficiency Anemia Nos
Siderosis	Pulmonary Siderosis Deposition Of Iron Arc-Welders' Disease Arc-Welders' Lung Arc-Welders' Nodulation Arc-Welders' Pneumoconiosis Iron Oxide Lung Iron Pneumoconiosis Pneumoconiosis Siderotico Siderotic Lung Disease Steel Grinders' Disease Welders' Lung Welders' Siderosis Lung Fibrosis With Siderosis
Protein-Energy Malnutrition	PEM Protein Energy Malnutrition
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Microcytic Anemia	Iron-Refractory Iron Deficiency Anemia
Hfe Hemochromatosis	Hemochromatosis Type 1 Hfe-Associated Hemochromatosis Hfe-Hh
Rare Hereditary Hemochromatosis	Iron Overload Iron Overload Disease Idiopathic Haemosiderosis Hemosiderosis
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Haemophilus Influenzae
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Congenital Disorder Of Glycosylation, Type Ia	CDG1A Cdg Ia Phosphomannomutase 2 Deficiency Jaeken Syndrome Pmm2-Congenital Disorder Of Glycosylation Congenital Disorder Of Glycosylation Type Ia Cdgia Congenital Disorder Of Glycosylation Ia Congenital Disorder Of Glycosylation 1a Carbohydrate-Deficient Glycoprotein Syndrome Type Ia Cdgs1a Pmm2-Cdg Cdg-Ia Congenital Disorder Of Glycosylation Type 1a Carbohydrate-Deficient Glycoprotein Syndrome, Type Ia, Formerly Pmm Deficiency Cdg Syndrome Type Ia Carbohydrate Deficient Glycoprotein Syndrome Type Ia Cdg Syndrome Type 1a Jaeken'S Syndrome Pmm2 Deficiency Glycosylation, Congenital Disorder Of, Type Ia
Dysentery	Infectious Diarrhea
Intracranial Hypotension
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders
Thalassemia	Sickle-Cell Thalassemia With Crisis Sickle-Cell Thalassemia Without Crisis Thalassemia Hb-S Disease With Crisis Thalassemia Hb-S Disease Without Crisis Thalassemias Hereditary Leptocytosis Haemoglobin Thalassaemia Disorder Thalassaemia Syndrome Thalassaemia Nos Thalassemia Variants
Porphyria Cutanea Tarda	Hepatoerythropoietic Porphyria HEP Uroporphyrinogen Decarboxylase Deficiency Pct Pct, Type Ii Porphyria, Hepatocutaneous Type Urod Deficiency Porphyria, Hepatoerythropoietic Porphyria Cutanea Tarda, Susceptibility To Familial Porphyria Cutanea Tarda Porphyria Cutanea Tarda, Type Ii Pct, 'Familial' Type Porphyria, Hepatic FPCT Pct Type Ii Porphyria Cutanea Tarda Type Ii Porphyria Hepatocutaneous Type Heterozygous Uroporphyrinogen Decarboxylase Deficiency Urod - [Uroporphyrinogen Decarboxylase] Deficiency Pct - [Porphyria Cutanea Tarda]
Hemosiderosis	Haemosiderosis Iron Overload
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Hyperferritinemia With Or Without Cataract	Hyperferritinemia-Cataract Syndrome Hhcs Hereditary Hyperferritinemia With Congenital Cataracts Hyperferritinemia, Hereditary, With Congenital Cataracts Bonneau-Beaumont Syndrome HRFTC Hereditary Hyperferritinemia-Cataract Syndrome Cataract-Hyperferritinemia Syndrome Hyperferritinemia Cataract Syndrome Hereditary Hyperferritinemia Cataract Syndrome
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Hypochromic Microcytic Anemia	Anemia, Hypochromic Microcytic Microcytic Hypochromic Anemia
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Analbuminemia	ANALBA Congenital Analbuminemia Hypoalbuminemia
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Trypanosomiasis
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Congenital Hemolytic Anemia	Anemia Hemolytic Congenital Anemia, Hemolytic, Congenital Congenital Hemolytic Anaemia Hereditary Hemolytic Anaemia Hereditary Hemolytic Anemia
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Hemoglobinopathy	Hemoglobinopathies
Lipoid Nephrosis	Minimal Change Disease Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome Idiopathic Minimal Change Nephrotic Syndrome Mcns Minimal Change Glomerulopathy Minimal Change Nephrotic Syndrome Nephrotic Syndrome Minimal Change Nephrosis, Lipoid Glomerulonephritis, Minimal Change Nephrotic Syndrome, Minimal Change
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Histoplasmosis	Darling Disease Reticuloendotheliosis, X-Linked Infection By Histoplasma Capsulatum Histoplasma Infection Reticuloendothelial Cytomycosis Cytomycosis Darling Histoplasmosis African Histoplasmosis Histoplasmosis Duboisii
Proctitis	Ulcerative Proctitis Chronic Ulcerative Proctitis Idiopathic Proctitis Nonspecific Ulcerative Proctitis Ulcerative Colitis Confined To Rectum Ip - [Idiopathic Proctitis] Chronic Ulcerative Proctitis Nos
Androgen Insensitivity Syndrome	Androgen Resistance Syndrome AIS Testicular Feminization Syndrome Androgen Receptor Deficiency Dhtr Deficiency Dihydrotestosterone Receptor Deficiency Ar Deficiency Testicular Feminization Tfm Androgen Insensitivity Androgen-Insensitivity Syndrome Goldberg-Maxwell Syndrome Complete Androgen Insensitivity Syndrome Cais Feminisation - Testicular Goldberg - Maxwell Syndrome Androgen Insensitivity Syndrome, Complete Morris Syndrome Ary AR Insensitivity Syndrome, Androgen Androgen Insensitivity Nos
Osebold-Remondini Syndrome	Brachydactyly Type A6 Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities Bda6 Brachydactyly, Type A6
Scrapie
Marasmus	Nutritional Marasmus Nutritional Atrophy
Cystinosis	Cystine Storage Disease Cystine Diathesis Cystine Disease Cystinoses Protein Defect Of Cystin Transport Cystin Transport, Protein Defect Of Nephropathic Cystinosis Protein Defect Of Cystine Transport
Diabetes Mellitus	Diabetes
Vitreoretinopathy, Neovascular Inflammatory	Proliferative Vitreoretinopathy Adniv Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy VRNI Pvr Neovascular Inflammatory Vitreoretinopathy Vitreoretinopathy, Neovascular Inflammatory, Autosomal Dominant Retinitis Proliferans Neovascular Inflammatory Vitreoretinopathy Autosomal Dominant Vitreoretinopathy Proliferative Vitreoretinopathy, Proliferative Proliferative Vitreo-Retinopathy
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152963	Tisotumab vedotin		97.20%	Unkown
HY-P0171	Motixafortide	Antagonist	99.76%	Unkown
HY-18763	Indobufen	Inhibitor	99.98%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P5533	CRT		99.76%	Phase 4
HY-19284	FR-146687	Inhibitor	/	Phase 2
HY-N1992	Theaflavin 3,3'-digallate	Inhibitor	99.89%	Phase 1
HY-153480A	ARC19499 sodium	Inhibitor	99.40%	Phase 1

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990090	Rademikibart	Inhibitor	99.13%	Phase 3
HY-P99271A	Tisotumab (powder)		/	Phase 3
HY-P991378	MORAb-066	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100388	SHP099	Inhibitor	99.81%	Unkown
HY-134094	Fluridone		99.93%	Unkown
HY-N2099	Onjisaponin B	Inhibitor	99.31%	Unkown
HY-NP0182	Peanut Agglutinin (Biotinylated)		/	Unkown
HY-173444	HDAC11-IN-3		99.70%	Unkown
HY-P5875A	P4pal10 TFA	Antagonist	98.25%	Unkown
HY-116170	SN34037	Inhibitor	99.02%	Unkown
HY-153480	ARC19499	Inhibitor	93.65%	Unkown
HY-13496	JNJ-28312141	Inhibitor	/	Unkown
HY-13496A	JNJ-28312141 hydrochloride	Inhibitor	/	Unkown
HY-145743	CP-17	Inhibitor	/	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.10%	Unkown
HY-156158	IDH2R140Q-IN-2	Inhibitor	/	Unkown
HY-162490	TF-S14	Inhibitor	/	Unkown
HY-169335	HIV-1 inhibitor-77	Inhibitor	/	Unkown
HY-170723	JAK-IN-39	Inhibitor	/	Unkown
HY-172905	BCX-3607		/	Unkown
HY-18763A	Indobufen sodium	Inhibitor	/	Unkown
HY-18763S	Indobufen-d5	Inhibitor	/	Unkown
HY-N10310	TF-3-G-cThea		/	Unkown
HY-N15874	C16/C11-TF/C12-DNP TG		/	Unkown
HY-N2099A	(Z)-Onjisaponin B		/	Unkown
HY-P5152	Scorpion toxin Tf2	Activator	/	Unkown
HY-P5875	P4pal10	Antagonist	/	Unkown
HY-RS04643	F3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14406	TF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174724	Human CXCR5 mRNA		/	Unkown
HY-N10309	TF-3ʹ-G-cThea		/	Unkown
HY-RS16867	F3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21604	Itpr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23170	Tf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23308	F3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99271	Tisotumab		99.90%	Unkown
HY-P991619	CNTO-860	Inhibitor	/	Unkown
HY-P992360	GT-002	Modulator	/	Unkown
HY-P991989	MRG004A Antibody		95.44%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TF	VGNC	VGNC:82716
Mus musculus	TF	MGD	MGI:98821
Rattus norvegicus	TF	RGD	RGD:3845
Others	TF	NCBI