Mitf - melanocyte inducing transcription factor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25094

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Involved in transcription, DNA-templated. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg syndrome type 2A; Waardenburg's syndrome; and familial melanoma. Orthologous to human MITF (melanocyte inducing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Mitf Products (2)

mRNA Protein Name
NM_001191089.4 NP_001178018.1 microphthalmia-associated transcription factor isoform 1
NM_001398550.1 NP_001385479.1 microphthalmia-associated transcription factor isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in DNA-templated transcription IDA
IDA: Inferred from direct assay
19524539 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in osteoclast differentiation IEP
IEP: Inferred from expression pattern
22576626 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
22576626 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microphthalmia-associated transcription factor

  • melanogenesis associated transcription factor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113337 Ap4A Inducer / Phase 2

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101464 ML329 Inhibitor 98.0% Unkown
HY-156483 TT-012 Inhibitor 99.76% Unkown
HY-113337A Ap4A tetraammonium Inducer 99.98% Unkown
HY-D0168 Orcinol 99.97% Unkown
HY-N1775 3',4'-Dihydroxyacetophenone 99.92% Unkown
HY-N1481 Methyl linoleate Inhibitor 98.0% Unkown
HY-N2413 Gomisin D 99.56% Unkown
HY-N2983 Cajanin Inhibitor 99.96% Unkown
HY-179717 WZS0347 Degrader 99.06% Unkown
HY-169363 PDL1 degrader-2 99.41% Unkown
HY-N12267 N,N′-Diferuloylputrescine Inhibitor 97.0% Unkown
HY-N2204 Swertiajaponin Inhibitor 98.53% Unkown
HY-179718 TT-012-Br Degrader 96.49% Unkown
HY-N10016 Chlorogenic acid butyl ester Inhibitor 98.19% Unkown
HY-N4280 7,8-Dimethoxycoumarin Inhibitor 99.75% Unkown
HY-RS08467 MITF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124857 7DG Inhibitor 98% Unkown
HY-N6901 Luteolin 7-sulfate ≥95.0% Unkown
HY-RS16290 Mitf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120996 10(E)-Pentadecenoic acid Inhibitor 99.90% Unkown
HY-159917 PPL agonist-1 / Unkown
HY-179720 TT-012-NH-C7-NHBoc / Unkown
HY-N0113A Hordenine sulfate / Unkown
HY-N10437 6-Acetylnimbandiol Inhibitor / Unkown
HY-N17896 Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside / Unkown
HY-N3810 ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid Inhibitor / Unkown
HY-P4497 Prolylserine / Unkown
HY-157010 AP736 Inhibitor / Unkown
HY-174580 Human MITF mRNA / Unkown
HY-N10623 5-epi-Arvestonate A Activator / Unkown
HY-RS17594 Tff3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23266 Mitf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mitf NCBI NCBI:4286