ROS1 - ROS proto-oncogene 1 , receptor tyrosine kinase Gene

Also Known as ROS1C

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25346

About ROS1

Primary_assembly 20: 31,432,637-31,583,865 reverse strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 125 orthologues, 54 paralogues and is associated with 10 phenotypes. Biased expression in Heart (RPKM 15.7), Kidney (RPKM 82.) and 3 other tissues.

Summary

Predicted to enable protein Phosphatase binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including columnar/cuboidal epithelial cell development; positive regulation of kinase activity; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; and regulation of phosphate transport. Predicted to be located in cell surface and perinuclear region of cytoplasm. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

ROS1 Products (1)

mRNA Protein Name
NM_012874.1 NP_037006.1 proto-oncogene tyrosine-protein kinase ROS precursor

ROS1 Protein Structure

FN3

FN3: smart00060 (110 - 177)

FN3

FN3: cd00063 (210 - 289)

FN3

FN3: cd00063 (566 - 662)

FN3

FN3: cd00063 (1035 - 1141)

FN3

FN3: smart00060 (1448 - 1526)

FN3

FN3: cd00063 (1550 - 1629)

FN3

FN3: cd00063 (1649 - 1740)

FN3

FN3: cd00063 (1745 - 1838)

PTKc_c-ros

PTKc_c-ros: cd05044 (1947 - 2208)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2339 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase ROS

  • Ros1 proto-oncogene

  • c-Ros receptor tyrosine kinase

  • c-ros oncogene 1 , receptor tyrosine kinase

  • c-ros-1

  • heart - derived c - ros - 1 proto - oncogene

  • proto-oncogene c-Ros

  • proto-oncogene c-Ros-1

  • proto-oncogene tyrosine-protein kinase ROS-like

  • receptor tyrosine kinase c-ros oncogene 1

  • v-ros UR2 sarcoma virus oncogene homolog 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50878 Crizotinib Inhibitor 99.97% Yes
HY-12215 Lorlatinib 99.99% Yes
HY-W015913 Pyruvic acid sodium Inhibitor 99.86% Yes
HY-12678 Entrectinib 99.26% Yes
HY-103022 Repotrectinib Inhibitor 99.95% Unkown
HY-50878A Crizotinib hydrochloride 99.86% Yes
HY-145574 Iruplinalkib Inhibitor 99.62% Unkown
HY-12215R Lorlatinib (Standard) 99.92% Unkown
HY-50878B Crizotinib acetate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-131003A Taletrectinib free base Inhibitor / Phase 3
HY-176942 JYP0322 Inhibitor / Phase 3
HY-131003 Taletrectinib Inhibitor 99.63% Phase 2
HY-152292 Zidesamtinib Inhibitor 99.78% Phase 2
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-155163 APG-2449 Inhibitor 98.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (55)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0578 Apigenin 7-glucoside 98.98% Unkown
HY-W015913S Pyruvic acid-13C3 sodium Inhibitor 99.7% Unkown
HY-122311 Orniplabin Inhibitor 98% Unkown
HY-159147 SIA​​IS039 99.68% Unkown
HY-12678S1 Entrectinib-d8 99.82% Unkown
HY-N7798 Pennogenin 99.90% Unkown
HY-B1106 Tetrahydroxyquinone 98.0% Unkown
HY-50878S Crizotinib-d5 99.60% Unkown
HY-112801 F-1 Inhibitor 98.03% Unkown
HY-12678S Entrectinib-d4 Inhibitor / Unkown
HY-B1106A Tetrahydroxyquinone monohydrate 97.0% Unkown
HY-N10144 Shinpterocarpin Inhibitor / Unkown
HY-N1306 Sideroxylin / Unkown
HY-N2693 6,8-Diprenylorobol 98.40% Unkown
HY-W015913R Pyruvic acid sodium (Standard) Inhibitor 99.98% Unkown
HY-161358 FAK-IN-20 / Unkown
HY-111416 WY-135 Inhibitor / Unkown
HY-135509 Lorlatinib acetate / Unkown
HY-115541 BRD4-IN-41 Inhibitor / Unkown
HY-117420 CM764 Activator / Unkown
HY-120387 SMU-B Inhibitor / Unkown
HY-122311A Bis(2R,3R)-Orniplabin 95.0% Unkown
HY-123454 SKF1 / Unkown
HY-130794 ALK/ROS1-IN-1 Inhibitor / Unkown
HY-144697 p38 MAPK-IN-3 / Unkown
HY-147795 Nampt-IN-8 / Unkown
HY-150974 ROS1-IN-1 Inhibitor / Unkown
HY-153743 Protein kinase inhibitor 4 Inhibitor / Unkown
HY-155178 Antiproliferative agent-34 Inhibitor / Unkown
HY-156360 Xanthine oxidase-IN-12 Inhibitor / Unkown
HY-157391 ALK/ROS1-IN-3 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-158016 Antiproliferative agent-49 / Unkown
HY-161966 VEGFR-2-IN-52 / Unkown
HY-161975 ROS1-IN-2 Inhibitor / Unkown
HY-162311 Anticancer agent 194 / Unkown
HY-163862 PPARα agonist 3 / Unkown
HY-170418 ALK/ROS1-IN-5 / Unkown
HY-178391 SMU-037 / Unkown
HY-179052 Apoptosis inducer 50 / Unkown
HY-179527 LIG48 Inhibitor / Unkown
HY-50878AS Crizotinib-d9 hydrochloride / Unkown
HY-N11887 Linocinnamarin Inhibitor 99.14% Unkown
HY-RS12135 ROS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12136 Ros1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12137 ROS1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160172 ALK/ROS1-IN-4 Inhibitor / Unkown
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / Unkown
HY-162488 Laccase-IN-3 Inhibitor / Unkown
HY-179710 SET-12 / Unkown
HY-50878S1 Crizotinib-d8 / Unkown
HY-50878S2 Crizotinib-d9 / Unkown
HY-B0847S Propiconazole-d7 / Unkown
HY-W587743 N1-Acetyl-5-methoxykynuramine hydrochloride Inhibitor / Unkown
HY-W927359 Fluorescein hydrazide (3,6-Dihydroxyxanthane) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ROS1 NCBI NCBI:6098