Cd36 - CD36 molecule Gene

Also Known as Fat; RGD1562323

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29184

Summary

Enables several functions, including oleic acid binding activity; scavenger receptor activity; and thrombospondin receptor activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule metabolic process; and response to peptide hormone. Located in several cellular components, including brush border membrane; caveola; and sarcolemma. Part of protein-containing complex. Used to study interstitial lung disease (multiple); macular degeneration; myocardial infarction; obesity; and polycystic ovary syndrome. Biomarker of artery disease (multiple); hypertrophic cardiomyopathy; nephrosis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd36 Products (1)

mRNA Protein Name
NM_031561.2 NP_113749.2 platelet glycoprotein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oleic acid binding IDA
IDA: Inferred from direct assay
8320718 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15161924 RGD
enables scavenger receptor activity IMP
IMP: Inferred from mutant phenotype
18941241 RGD
enables thrombospondin receptor activity IDA
IDA: Inferred from direct assay
10487979 RGD
enables transforming growth factor beta binding IDA
IDA: Inferred from direct assay
10487979 RGD
Biological Process GO Annotation Evidence References Source
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: Inferred from mutant phenotype
18941241 RGD
involved in cell-cell adhesion via plasma-membrane adhesion molecules IEP
IEP: Inferred from expression pattern
24317495 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
19273501 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
11595646 RGD
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
25477422 RGD
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
23557700 RGD
involved in fatty acid metabolic process IDA
IDA: Inferred from direct assay
11729182 RGD
involved in fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
11175782 RGD
involved in fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
15161924 RGD
involved in fatty acid transport IDA
IDA: Inferred from direct assay
14748718 RGD
involved in fatty acid transport IEP
IEP: Inferred from expression pattern
16684853 RGD
involved in fatty acid transport IMP
IMP: Inferred from mutant phenotype
15331529 RGD
involved in long-chain fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
15161924 RGD
involved in long-chain fatty acid transport IMP
IMP: Inferred from mutant phenotype
9315741 RGD
involved in maternal placenta development IEP
IEP: Inferred from expression pattern
24391823 RGD
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
18772338 RGD
involved in negative regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
22128087 RGD
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
20075072 RGD
involved in positive regulation of glycogen biosynthetic process IDA
IDA: Inferred from direct assay
14640889 RGD
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
23238794 RGD
involved in positive regulation of triglyceride metabolic process IDA
IDA: Inferred from direct assay
23099442 RGD
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
18941241 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
17374701 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17640331 RGD
involved in response to fatty acid IDA
IDA: Inferred from direct assay
21610069 RGD
involved in response to fatty acid IMP
IMP: Inferred from mutant phenotype
23557700 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
17640331 RGD
involved in response to lipid IMP
IMP: Inferred from mutant phenotype
21610069 RGD
involved in response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
18772338 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17640331 RGD
involved in response to vitamin B3 IEP
IEP: Inferred from expression pattern
19878707 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15492479 RGD
involved in triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
15331529 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
9315741 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
21610069 RGD
located in caveola IDA
IDA: Inferred from direct assay
12637562 RGD
located in cell surface IDA
IDA: Inferred from direct assay
10487979 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
20237389 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
12829625 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet glycoprotein 4

  • CD36 antigen (collagen type I receptor, thrombospondin receptor)

  • CD36 molecule (thrombospondin receptor)

  • Cd36 antigen-like

  • GPIIIB

  • GPIV

  • PAS IV

  • PAS-4

  • adipocyte membrane protein

  • collagen type I receptor thrombospondin receptor

  • fatty acid translocase

Recombinant Cd36 Proteins

Cat. No. Product Name Accession Purity
HY-P74302 CD36 Protein, Rat (HEK293, His) Q07969 (G30-K439) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74303 CD36 Protein, Rat (HEK293, Fc) Q07969 (G30-K439) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-155938 Cyano-myracrylamide Inhibitor 98.13% Phase 3
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991911 PLT012 Inhibitor 98.90% Phase 1

Pre-clinical Phase

Bioactive Molecules (40)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112847A Sulfosuccinimidyl oleate sodium Inhibitor 99.66% Unkown
HY-163541 SMS121 Inhibitor 99.06% Unkown
HY-113402 Gamma-glutamylcysteine 98.53% Unkown
HY-NP165 Advanced glycation end products / Unkown
HY-P3970A KRFK TFA Agonist 99.76% Unkown
HY-P5322 Thrombospondin (TSP-1)-derived CD36 binding motif 99.58% Unkown
HY-113402A Gamma-glutamylcysteine TFA 96.68% Unkown
HY-30216 (R)-Leucic acid 98.0% Unkown
HY-126726 KOdiA-PC 99.00% Unkown
HY-163649 A17 Activator 99.4% Unkown
HY-W040255 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine 99.9% Unkown
HY-128671 6-​Thioinosine 99.31% Unkown
HY-NP203 High density lipoprotein (human) Activator 98.00% Unkown
HY-113402R Gamma-glutamylcysteine (Standard) 98.14% Unkown
HY-168049 ZLY06 Agonist 98.75% Unkown
HY-RS02237 CD36 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112847 Sulfosuccinimidyl oleate Inhibitor / Unkown
HY-116003 12,13-DiHOME 99.5% Unkown
HY-154857 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine Ligand / Unkown
HY-113402AR Gamma-glutamylcysteine TFA (Standard) / Unkown
HY-RS16502 Cd36 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18098 Scarb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-108385 Ochratoxin A-D4 / Unkown
HY-112847B (E/Z)-Sulfosuccinimidyl oleate sodium / Unkown
HY-125554 KDdiA-PC Ligand / Unkown
HY-168371 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC / Unkown
HY-172944 GPR40 Activator 3 Activator / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-P10183 CD36 Peptide P (139-155), Cys conjugated Inhibitor / Unkown
HY-P10184 CD36 Peptide P (93-110), Cys conjugated Inhibitor / Unkown
HY-P10873 ST-CY14 / Unkown
HY-P11033 Pep2 Peptide Ligand / Unkown
HY-P11227 Compound 19A8.8 Inhibitor / Unkown
HY-P2696 EP 80317 Ligand / Unkown
HY-P2696A EP 80317 acetate Ligand 99.16% Unkown
HY-P3970 KRFK Agonist / Unkown
HY-W769935 5-POHSA Modulator / Unkown
HY-10380 (R)-DRF053 Inhibitor / Unkown
HY-113402B Gamma-glutamylcysteine ammonium / Unkown
HY-RS22934 Cd36 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990352 Anti-CD36 Antibody Inhibitor 99.43% Unkown
HY-P990353 Anti-CD4 Antibody (TRX1) Inhibitor 99.28% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd36 NCBI NCBI:948