CD36 - CD36 molecule Gene
Also Known as FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
Species: Homo sapiens
About CD36
This gene has 24 transcripts (splice variants), 251 orthologues, 2 paralogues and is associated with 3 phenotypes. Biased expression in fat (RPKM 547.7), heart (RPKM 79.1) and 4 other tissues.
Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to Collagen, thrombospondin, anionic Phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
CD36 Products (15)
| mRNA | Protein | Name |
|---|---|---|
| NM_000072.3 | NP_000063.2 | platelet glycoprotein 4 isoform 1 |
| NM_001001547.3 | NP_001001547.1 | platelet glycoprotein 4 isoform 1 |
| NM_001001548.3 | NP_001001548.1 | platelet glycoprotein 4 isoform 1 |
| NM_001127443.2 | NP_001120915.1 | platelet glycoprotein 4 isoform 1 |
| NM_001127444.2 | NP_001120916.1 | platelet glycoprotein 4 isoform 1 |
| NM_001289908.1 | NP_001276837.1 | platelet glycoprotein 4 isoform 2 |
| NM_001289909.1 | NP_001276838.1 | platelet glycoprotein 4 isoform 3 |
| NM_001289911.2 | NP_001276840.1 | platelet glycoprotein 4 isoform 4 |
| NM_001371074.1 | NP_001358003.1 | platelet glycoprotein 4 isoform 1 |
| NM_001371075.1 | NP_001358004.1 | platelet glycoprotein 4 isoform 1 |
| NM_001371077.1 | NP_001358006.1 | platelet glycoprotein 4 isoform 1 |
| NM_001371078.1 | NP_001358007.1 | platelet glycoprotein 4 isoform 1 |
| NM_001371079.1 | NP_001358008.1 | platelet glycoprotein 4 isoform 5 |
| NM_001371080.1 | NP_001358009.1 | platelet glycoprotein 4 isoform 6 |
| NM_001371081.1 | NP_001358010.1 | platelet glycoprotein 4 isoform 6 |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in Golgi apparatus |
IDA
IDA: Inferred from direct assay
|
16880211 | GOA |
| located in cell periphery |
IDA
IDA: Inferred from direct assay
|
26449856 | GOA |
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
10772654 | GOA |
| located in membrane raft |
IDA
IDA: Inferred from direct assay
|
16880211 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
22022213 | GOA |
| part of receptor complex |
IPI
IPI: Inferred from physical interaction
|
20037584 | GOA |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
platelet glycoprotein 4 |
|
CD36 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CD36 | P16671 | UNG | Homo sapiens | P13051-2 | 32814053 | |
|
Intra
|
CD36 | P16671 | UNG | Homo sapiens | P13051-2 | 32814053 | |
|
Intra
|
CD36 | P16671 | UNG | Homo sapiens | P13051-2 | 32814053 | |
|
Intra
|
CD36 | P16671 | LYN | Homo sapiens | P07948 | 20037584 | |
|
Intra
|
CD36 | P16671 | LYN | Homo sapiens | P07948 | 20037584 |
Recombinant CD36 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70004 | CD36 Protein, Human (HEK293, Fc ) | P16671-1 (G30-N439) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78409 | CD36 Protein, Human (HEK293, His-Avi) | P16671-1 (G30-N439) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78909 | CD36 Protein, Human (Biotinylated, HEK293, His-Avi) | P16671-1 (G30-N439) | ≥ 95%, as determined by reducing SDS-PAGE. |
CD36 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81793 | CD36 Antibody (YA1538) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P81793A | CD36 Antibody (YA1538)(PBS only) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P85802 | CD36 Antibody (YA5494) | FC, ELISA | Human |
| HY-P86458 | CD36 Antibody (YA6150) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Platelet Glycoprotein Iv Deficiency |
|
|
| Coronary Heart Disease 7 |
|
|
| Malaria |
|
|
| Blood Platelet Disease |
|
|
| Hypertrophic Scars |
|
|
| Hypertensive Heart Disease |
|
|
| Plasmodium Falciparum Malaria |
|
|
| Osteogenesis Imperfecta, Type I |
|
|
| Babesiosis |
|
|
| Renal Fibrosis |
|
|
| Osteofibrous Dysplasia |
|
|
| Osteoporosis |
|
|
| Osteogenesis Imperfecta, Type V |
|
|
| Osteogenesis Imperfecta, Type Iv |
|
|
| Bone Disease |
|
|
| Osteogenesis Imperfecta, Type Iii |
|
|
| Gingival Overgrowth |
|
|
| Keloid Disorder |
|
|
| Reflex Sympathetic Dystrophy |
|
|
| Chancroid |
|
|
| Caffey Disease |
|
|
| Corneal Neovascularization |
|
|
| Osteogenesis Imperfecta, Type Ii |
|
|
| Ehlers-Danlos Syndrome |
|
|
| Rickets |
|
|
| Thrombotic Thrombocytopenic Purpura |
|
|
| Farmer'S Lung |
|
|
| Osteomalacia |
|
|
| Chronic Ulcer Of Skin |
|
|
| Heart Disease |
|
|
| Pulmonary Fibrosis |
|
|
| Scleroderma, Familial Progressive |
|
|
| Ehlers-Danlos Syndrome, Classic Type, 2 |
|
|
| Fibromatosis, Gingival, 1 |
|
|
| Achondrogenesis, Type Ii |
|
|
| Fibrosarcoma |
|
|
| Non-Alcoholic Fatty Liver Disease |
|
|
| Primary Hyperparathyroidism |
|
|
| Gray Platelet Syndrome |
|
|
| Brittle Bone Disorder |
|
|
| Fatty Liver Disease |
|
|
| Melorheostosis |
|
|
| Osteochondritis Dissecans |
|
|
| Collagen Disease |
|
|
| Otosclerosis |
|
|
| Atherosclerosis Susceptibility |
|
|
| Thrombasthenia |
|
|
| Pilomatrixoma |
|
|
| Marfan Syndrome |
|
|
| Idiopathic Scoliosis |
|
|
| Acute Megakaryocytic Leukemia |
|
|
| Dermatofibrosarcoma Protuberans |
|
|
| Chronic Kidney Disease |
|
|
| Dentinogenesis Imperfecta |
|
|
| Kidney Disease |
|
|
| Connective Tissue Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Aortic Atherosclerosis |
|
|
| Rheumatoid Arthritis |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Osteoporosis, Juvenile |
|
|
| Acute Hemorrhagic Encephalitis |
|
|
| Non-Alcoholic Steatohepatitis |
|
|
| Cutis Laxa |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Erythema Infectiosum |
|
|
| Colorectal Cancer |
|
|
| Open-Angle Glaucoma |
|
|
| Thrombocytopenia |
|
|
| Diabetes Mellitus |
|
|
| Pancreatic Cancer |
|
|
| Osteogenic Sarcoma |
|
|
| Dilated Cardiomyopathy |
|
|
| Prostate Cancer |
|
|
| Myocardial Infarction |
|
|
| Cerebral Palsy |
|
|
| Lipid Storage Disease |
|
|
| Melanoma |
|
|
| Inflammatory Bowel Disease |
|
|
| Overnutrition |
|
|
| Lipid Metabolism Disorder |
|
|
| Acquired Metabolic Disease |
|
|
| Late Congenital Syphilis |
|
|
| Hypertension, Essential |
|
|
| Sickle Cell Anemia |
|
|
| Breast Cancer |
|
|
| Myeloma, Multiple |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Nervous System Disease |
|
|