2. Gene
  3. Fto - FTO, alpha-ketoglutarate dependent dioxygenase Gene

Fto - FTO, alpha-ketoglutarate dependent dioxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1305121

Gene ID: 291905 | Gene type: protein coding

About Fto

Primary_assembly 19: 15,349,696-15,692,083 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 202 orthologues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 136.3), Kidney (RPKM 111.9) and 9 other tissues.

Summary

Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Predicted to be involved in several processes, including mRNA destabilization; nucleic acid metabolic process; and regulation of respiratory system process. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Fto Products(1)

mRNA Protein Name
NM_001039713.1 NP_001034802.1 alpha-ketoglutarate-dependent dioxygenase FTO

Fto Protein Structure

FTO_NTD

FTO_NTD: pfam12933 (35 - 321)

FTO_CTD

FTO_CTD: cl15176 (325 - 493)

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  • 502 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase FTO

U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

fat mass and obesity associated

fat mass and obesity-associated protein

m6A(m)-demethylase FTO

mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

mRNA N(6)-methyladenosine demethylase FTO

protein fto

tRNA N1-methyl adenine demethylase FTO

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14280 Entacapone Inhibitor 99.92% Yes
HY-B1320 Meclofenamic acid sodium 99.86% Unkown
HY-117275 Meclofenamic acid Inhibitor 98.60% Unkown
HY-117275A Meclofenamic acid sodium hydrate Inhibitor / Unkown
HY-14280R Entacapone (Standard) Inhibitor / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-127103 FB23-2 Inducer 99.93% Unkown
HY-137187 FB23 98.66% Unkown
HY-N6769 Radicicol Inhibitor 99.63% Unkown
HY-101082 N6,2′-O-Dimethyladenosine 99.93% Unkown
HY-151106 FTO-IN-8 Inhibitor 98.03% Unkown
HY-145238 FTO-IN-6 98.94% Unkown
HY-132865 FTO-IN-3 99.79% Unkown
HY-149334 ZLD115 Inhibitor 99.24% Unkown
HY-138843A FTO-IN-1 TFA 98.04% Unkown
HY-147011 FTO-IN-7 Inhibitor 99.22% Unkown
HY-14280S Entacapone-d10 Inhibitor ≥98.0% Unkown
HY-RS05137 Fto Mouse Pre-designed siRNA Set A / Unkown
HY-117275S Meclofenamic acid-d4 Inhibitor / Unkown
HY-117275S1 Meclofenamic acid-13C6 Inhibitor / Unkown
HY-117426 MO-I-500 Inhibitor / Unkown
HY-132863 FTO-IN-2 / Unkown
HY-138843 FTO-IN-1 / Unkown
HY-139820 FTO-IN-4 / Unkown
HY-139821 FTO-IN-5 / Unkown
HY-156405 FTO-IN-10 / Unkown
HY-N10340 Clausine E Inhibitor / Unkown
HY-RS05136 FTO Human Pre-designed siRNA Set A / Unkown
HY-RS05138 Fto Rat Pre-designed siRNA Set A / Unkown
HY-131871 Ethyl LipotF Inhibitor / Unkown
HY-W588293 3-Methylthymidine / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fto NCBI NCBI:79068