2. Gene
  3. Ezh2 - enhancer of zeste 2 polycomb repressive complex 2 subunit Gene

Ezh2 - enhancer of zeste 2 polycomb repressive complex 2 subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 312299 | Gene type: protein coding

About Ezh2

Primary_assembly 4: 76,624,399-76,687,362 reverse strand.mRatBN7.2:CM026977.1

This gene has 6 transcripts (splice variants), 237 orthologues, 23 paralogues and is associated with 59 phenotypes. Biased expression in Thymus (RPKM 228.6), Spleen (RPKM 17.5) and 9 other tissues.

Summary

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including histone H3-K27 methylation; negative regulation of macromolecule metabolic process; and positive regulation of dendrite development. Located in cytoplasm and nucleus. Used to study endometriosis. Biomarker of leiomyoma; non-alcoholic fatty liver disease; and pancreatic Cancer. Human ortholog(s) of this gene implicated in Weaver syndrome; bone Cancer (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung Cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ezh2 Products(1)

mRNA Protein Name
NM_001134979.1 NP_001128451.1 histone-lysine N-methyltransferase EZH2

Ezh2 Protein Structure

EZH2_WD-Binding

EZH2_WD-Binding: pfam11616 (38 - 67)

PRC2_HTH_1

PRC2_HTH_1: pfam18118 (157 - 248)

preSET_CXC

preSET_CXC: pfam18264 (563 - 594)

SET_EZH2

SET_EZH2: cd19218 (613 - 732)

  • 0
  • 200
  • 400
  • 600
  • 751 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EZH2

enhancer of zeste homolog 2

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13803 Tazemetostat Inhibitor 99.93% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145602 Tulmimetostat Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (37)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13470 GSK126 Inhibitor 99.98% Unkown
HY-12186 3-Deazaneplanocin A hydrochloride Inhibitor 99.98% Unkown
HY-13500 GSK343 Inhibitor 99.88% Unkown
HY-15646 UNC1999 Inhibitor 99.83% Unkown
HY-148333 MS177 Inhibitor 98.00% Unkown
HY-133129 MS1943 Inhibitor 98.02% Unkown
HY-16986 EPZ011989 Inhibitor 98.79% Unkown
HY-147525 PROTAC EZH2 Degrader-1 Inhibitor 98.55% Unkown
HY-12856 GSK503 Inhibitor 99.52% Unkown
HY-100846 JQEZ5 Inhibitor 98.08% Unkown
HY-15555 EPZ005687 Inhibitor 99.79% Unkown
HY-N5024 Gambogenic acid Inhibitor 99.94% Unkown
HY-103682 PF-06726304 Inhibitor 98.37% Unkown
HY-15573 EI1 Inhibitor 99.78% Unkown
HY-147090 Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH Degrader 98.24% Unkown
HY-101508 GNA002 Inhibitor 98.02% Unkown
HY-A0298 EZH2-IN-2 Inhibitor 99.40% Unkown
HY-136188 UNC2399 Inhibitor 99.62% Unkown
HY-119198 NSC745885 Inhibitor ≥98.0% Unkown
HY-122936 Tanshindiol C Inhibitor 98.47% Unkown
HY-144881 (S)-HH2853 Inhibitor / Unkown
HY-16986A EPZ011989 trifluoroacetate Inhibitor 98.71% Unkown
HY-157844 NUCC-0226272 Degrader 98.07% Unkown
HY-144882 (R)-HH2853 Inhibitor / Unkown
HY-134899 CPI-1328 Inhibitor / Unkown
HY-12186G 3-Deazaneplanocin A hydrochloride (GMP) Inhibitor / Unkown
HY-103682A PF-06726304 acetate Inhibitor / Unkown
HY-141566 EZH2-IN-5 Inhibitor / Unkown
HY-156292 IHMT-EZH2-426 Inhibitor / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-163288 EZH2/HSP90-IN-29 Inhibitor / Unkown
HY-154854 BBDDL2059 Inhibitor / Unkown
HY-162250 MS8847 Inhibitor / Unkown
HY-161083 PARP/EZH2-IN-2 Inhibitor / Unkown
HY-146999 YM458 Inhibitor / Unkown
HY-131246 DM-01 Inhibitor 98.03% Unkown
HY-139150 EZH2-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ezh2 NCBI NCBI:2146