HSF2 - heat shock transcription factor 2 Gene

Homo sapiens

Also known as HSF 2; HSTF 2

Gene ID: 3298 | Gene type: protein coding

About HSF2

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,399,551-122,433,119 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 9 paralogues. Broad expression in testis (RPKM 22.1), bone marrow (RPKM 8.8) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

HSF2 Products(3)

mRNA	Protein	Name
NM_001135564.1	NP_001129036.1	heat shock factor protein 2 isoform b
NM_001243094.2	NP_001230023.1	heat shock factor protein 2 isoform c
NM_004506.4	NP_004497.1	heat shock factor protein 2 isoform a

HSF2 Protein Structure

HSF_DNA-bind

Vert_HS_TF

0
100
200
300
400
500
536 a.a.

Protein Preferred Names

Protein Names

heat shock factor protein 2

Recombinant HSF2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70406	HSF2 Protein, Human (His)	Q03933 (S411-S536)	≥95%

Related Diseases

Diseases

Alias

Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus

Spermatogenic Failure 14

SPGF14

Erythroleukemia

Spermatogenic Failure 15

SPGF15

Spermatogenic Failure, 15

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06409	HSF2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS06410	HSF2BP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HSF2	VGNC	VGNC:29982
Canis familiaris	HSF2	VGNC	VGNC:41815
Felis catus	HSF2	VGNC	VGNC:67662
Macaca mulatta	HSF2	VGNC	VGNC:81077
Mus musculus	HSF2	MGD	MGI:96239
Rattus norvegicus	HSF2	RGD	RGD:68395
Others	HSF2	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.