HSF2 - heat shock transcription factor 2 Gene

Also Known as HSF 2; HSTF 2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3298

About HSF2

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,399,551-122,433,119 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 9 paralogues. Broad expression in testis (RPKM 22.1), bone marrow (RPKM 8.8) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or Other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

HSF2 Products (3)

mRNA Protein Name
NM_001135564.1 NP_001129036.1 heat shock factor protein 2 isoform b
NM_001243094.2 NP_001230023.1 heat shock factor protein 2 isoform c
NM_004506.4 NP_004497.1 heat shock factor protein 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10561509 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8972228 GOA
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10561509 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10561509 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10561509 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSF2 Protein Structure

HSF_DNA-bind

HSF_DNA-bind: HSF-type DNA-binding (9 - 113)

Vert_HS_TF

Vert_HS_TF: Vertebrate heat shock transcription factor (229 - 512)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 536 a.a.
Protein Preferred Names Protein Names

heat shock factor protein 2

HSF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSF2 Q03933 TPM3 Homo sapiens Q5VU62
Validated Y2H
25416956
Intra
HSF2 Q03933 TPM3 Homo sapiens Q5VU62
Y2H Array
25416956
Intra
HSF2 Q03933 DERA Homo sapiens Q9Y315
Y2H Prey Pooling
32296183
Intra
HSF2 Q03933 DERA Homo sapiens Q9Y315
Validated Y2H
32296183
Intra
HSF2 Q03933 DERA Homo sapiens Q9Y315
Y2H Array
32296183
Intra
HSF2 Q03933 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
HSF2 Q03933 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
HSF2 Q03933 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
HSF2 Q03933 BAG4 Homo sapiens O95429
Anti Tag CoIP
33961781
Intra
HSF2 Q03933 BAG4 Homo sapiens O95429
Lumier
25036637
Intra
HSF2 Q03933 NUP62 Homo sapiens P37198
Y2H Array
31515488
Intra
HSF2 Q03933 NUP62 Homo sapiens P37198
Y2H Prey Pooling
25416956
Intra
HSF2 Q03933 BAG2 Homo sapiens O95816
Lumier
25036637
Intra
HSF2 Q03933 TPM3 Homo sapiens P06753
Y2H Prey Pooling
25416956
Intra
HSF2 Q03933 HSPA2 Homo sapiens P54652
Anti Tag CoIP
33961781
Intra
HSF2 Q03933 WDR5 Homo sapiens P61964
Y2H Array
25416956
Intra
HSF2 Q03933 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
HSF2 Q03933 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
HSF2 Q03933 HSF1 Homo sapiens Q00613
Anti Tag CoIP
33961781
Intra
HSF2 Q03933 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra
HSF2 Q03933 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
HSF2 Q03933 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
HSF2 Q03933 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
HSF2 Q03933 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
HSF2 Q03933 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSF2 Proteins

Cat. No. Product Name Accession Purity
HY-P70406 HSF2 Protein, Human (His) Q03933 (S411-S536) ≥ 95%, as determined by reducing SDS-PAGE.

HSF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82490 Hsf2 Antibody (YA2235) WB, ICC/IF, FC Human

Related Diseases

Diseases Alias
Spermatogenic Failure 10

  • SPGF10

  • Spermatogenic Failure With Defective Sperm Annulus
Spermatogenic Failure 14

  • SPGF14
Erythroleukemia
Spermatogenic Failure 15

  • SPGF15

  • Spermatogenic Failure, 15
Spermatogenic Failure, Y-Linked, 2

  • SPGFY2

  • Spermatogenic Failure, Nonobstructive, Y-Linked

  • Y-Linked Spermatogenic Failure 2

  • Azoospermia, Nonobstructive, Y-Linked

  • Oligozoospermia, Nonobstructive, Y-Linked

  • Oligospermia, Nonobstructive, Y-Linked

  • Spermatogenic Arrest, Y-Linked

  • Nonobstructive Y-Linked Spermatogenic Failure

  • Spermatogenic Failure Y-Linked 2

  • Azoospermia Non-Obstructive Y-Linked

  • Non-Obstructive Azoospermia And Infertility

  • Oligospermia Non-Obstructive Y-Linked

  • Oligozoospermia Non-Obstructive Y-Linked

  • Spermatogenic Arrest Y-Linked

  • Spermatogenic Failure Nonobstructive Y-Linked
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06409 HSF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06410 HSF2BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19141 Hsf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21866 Hsf2bp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25632 Hsf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28383 Hsf2bp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HSF2 VGNC VGNC:29982
Canis familiaris HSF2 VGNC VGNC:41815
Felis catus HSF2 VGNC VGNC:67662
Macaca mulatta HSF2 VGNC VGNC:81077
Mus musculus HSF2 MGD MGI:96239
Rattus norvegicus HSF2 RGD RGD:68395
Others HSF2 NCBI