Stat6 - signal transducer and activator of transcription 6 Gene

Rattus norvegicus

Gene ID: 362896 | Gene type: protein coding

About Stat6

Primary_assembly 7: 63,479,642-63,498,495 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 190 orthologues, 5 paralogues and is associated with 23 phenotypes. Biased expression in Spleen (RPKM 339.7), Lung (RPKM 271.4) and 9 other tissues.

Summary

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; and positive regulation of transcription by RNA polymerase II. Located in membrane raft and nucleus. Used to study asthma and renal fibrosis. Biomarker of asthma and myocarditis. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]

Stat6 Products(1)

mRNA	Protein	Name
NM_001044250.1	NP_001037715.1	signal transducer and activator of transcription 6

Stat6 Protein Structure

STAT_int

STAT6_CCD

STAT6_DBD

SH2_STAT6

STAT6_C

0
200
400
600
841 a.a.

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 6

signal transducer and activator of transcription 6, interleukin-4 induced

signal transducer and transcription activator 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100614	AS1517499	Inhibitor	99.17%	Unkown
HY-134772	AS1810722	Inhibitor	98.14%	Unkown
HY-134771	YM-341619	Inhibitor	99.06%	Unkown
HY-N0407	Picroside I	Inhibitor	99.55%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat6	NCBI	NCBI:6778

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