Stat6 - signal transducer and activator of transcription 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362896

About Stat6

Primary_assembly 7: 63,479,642-63,498,495 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 190 orthologues, 5 paralogues and is associated with 23 phenotypes. Biased expression in Spleen (RPKM 339.7), Lung (RPKM 271.4) and 9 other tissues.

Summary

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; and positive regulation of transcription by RNA polymerase II. Located in membrane raft and nucleus. Used to study asthma and renal fibrosis. Biomarker of asthma and myocarditis. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]

Stat6 Products (1)

mRNA Protein Name
NM_001044250.1 NP_001037715.1 signal transducer and activator of transcription 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
15584925 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16648019 RGD
enables sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
15584925 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
22504638 RGD
involved in cellular response to reactive nitrogen species IDA
IDA: Inferred from direct assay
22504638 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18362439 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15584925 RGD
involved in response to cytokine IMP
IMP: Inferred from mutant phenotype
18362439 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat6 Protein Structure

STAT_int

STAT_int: smart00964 (1 - 114)

STAT6_CCD

STAT6_CCD: cd16856 (104 - 275)

STAT6_DBD

STAT6_DBD: cd16850 (272 - 431)

SH2_STAT6

SH2_STAT6: cd10377 (516 - 645)

STAT6_C

STAT6_C: pfam14596 (654 - 840)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 841 a.a.
Protein Preferred Names Protein Names

signal transducer and activator of transcription 6

  • signal transducer and activator of transcription 6, interleukin-4 induced

  • signal transducer and transcription activator 6

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100754 Ritlecitinib Inhibitor 99.80% Yes
HY-B1076 Medrysone Modulator 99.79% Unkown
HY-100754C Ritlecitinib tosylate Inhibitor 99.65% Yes
HY-112961 Patiromer Inhibitor 95.0% Unkown
HY-100754A Ritlecitinib malonate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-123823 Nitroaspirin Inhibitor 98.57% Phase 2
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990093 Stapokibart Inhibitor 99.37% Phase 4
HY-P990090 Rademikibart Inhibitor 99.13% Phase 3

Pre-clinical Phase

Bioactive Molecules (40)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100614 AS1517499 Inhibitor 99.21% Unkown
HY-169179 AK-1690 Degrader 99.91% Unkown
HY-113402 Gamma-glutamylcysteine Activator 98.53% Unkown
HY-134771 YM-341619 Inhibitor 98.01% Unkown
HY-173236 STAT4-IN-1 Inhibitor 99.17% Unkown
HY-158399 STAT6-IN-5 Inhibitor 99.88% Unkown
HY-158398 STAT6-IN-4 Inhibitor 99.77% Unkown
HY-134772 AS1810722 Inhibitor 98.10% Unkown
HY-169182 AK-068 Ligand 99.67% Unkown
HY-169360 SD-436 Degrader 98.27% Unkown
HY-177456 STAT6 degrader-3 Degrader 99.26% Unkown
HY-176857 PROTAC STAT6 degrader-1 Degrader 99.55% Unkown
HY-117548 UNC1062 Inhibitor 98.92% Unkown
HY-N0407 Picroside I Inhibitor 99.31% Unkown
HY-176864 STAT6 ligand-1 Ligand 98.94% Unkown
HY-206870 BP79 Inhibitor / Unkown
HY-176949 STAT6-IN-10 Inhibitor 98.81% Unkown
HY-113509B 15(R)-Lipoxin A4 Inhibitor 98.3% Unkown
HY-123115 Leucrose 98.53% Unkown
HY-182359 YYSW001 Inhibitor / Unkown
HY-183837 PROTAC STAT6 degrader-8 Degrader / Unkown
HY-183834 PROTAC STAT6 degrader-7 Degrader / Unkown
HY-183733 STAT6 degrader-4 Degrader / Unkown
HY-183847 PROTAC STAT6 degrader-10 Degrader / Unkown
HY-162404 (14S,15R)-14-Deoxyoxacyclododecindione Inhibitor / Unkown
HY-179233 PROTAC STAT6 degrader-2 Degrader / Unkown
HY-164216 STAT6-IN-13 Inhibitor / Unkown
HY-171441 STAT6 degrader-1 Degrader / Unkown
HY-185073 STAT6-IN-11 Inhibitor / Unkown
HY-181901 PROTAC STAT6 degrader-4 Degrader / Unkown
HY-183839 PROTAC STAT6 degrader-9 Degrader / Unkown
HY-W1113771 STAT6-IN-7 Inhibitor 99.53% Unkown
HY-184991 AK305 Ligand / Unkown
HY-175650 STAT6-IN-9 Inhibitor 98.11% Unkown
HY-184119 Pabgraminone C Modulator / Unkown
HY-W1113770 STAT6-IN-8 Inhibitor 98.77% Unkown
HY-162405 STAT6-IN-12 Inhibitor / Unkown
HY-182699 PROTAC STAT6 degrader-5 Degrader / Unkown
HY-164216A (trans)-STAT6-IN-13 Modulator / Unkown
HY-184822 STAT6-IN-14 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat6 NCBI NCBI:6778