2. JAK/STAT Signaling Stem Cell/Wnt Immunology/Inflammation
  3. STAT Interleukin Related
  4. STAT6-IN-7

STAT6-IN-7 is a STAT6 inhibitor. STAT6-IN-7 exhibits an IC50 of 0.28 μM for inhibiting the binding of human STAT6/pIL-4Rα. STAT6-IN-7 can be used in the research of atopic dermatitis.

For research use only. We do not sell to patients.

STAT6-IN-7

STAT6-IN-7 Chemical Structure

CAS No. : 3033743-58-4

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STAT6-IN-7 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

STAT6-IN-7 is a STAT6 inhibitor. STAT6-IN-7 exhibits an IC50 of 0.28 μM for inhibiting the binding of human STAT6/pIL-4Rα. STAT6-IN-7 can be used in the research of atopic dermatitis[1].

IC50 & Target

STAT6

 

IL-4

 

In Vitro

STAT6-IN-7 (Compound 178) is a STAT6 inhibitor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STAT6-IN-7 Related Antibodies
Molecular Weight

698.69

Formula

C36H33F3N8O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(NC(C2=CC(C(F)(F)F)=CC3=C2N(CCOC)C(C4=CC=C(N5C(N(C)N=C5C)=O)C=C4)=C3)=O)=CC=C1)NC6=NN(C7CC7)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (143.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4312 mL 7.1562 mL 14.3125 mL
5 mM 0.2862 mL 1.4312 mL 2.8625 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4312 mL 7.1562 mL 14.3125 mL 35.7812 mL
5 mM 0.2862 mL 1.4312 mL 2.8625 mL 7.1562 mL
10 mM 0.1431 mL 0.7156 mL 1.4312 mL 3.5781 mL
15 mM 0.0954 mL 0.4771 mL 0.9542 mL 2.3854 mL
20 mM 0.0716 mL 0.3578 mL 0.7156 mL 1.7891 mL
25 mM 0.0572 mL 0.2862 mL 0.5725 mL 1.4312 mL
30 mM 0.0477 mL 0.2385 mL 0.4771 mL 1.1927 mL
40 mM 0.0358 mL 0.1789 mL 0.3578 mL 0.8945 mL
50 mM 0.0286 mL 0.1431 mL 0.2862 mL 0.7156 mL
60 mM 0.0239 mL 0.1193 mL 0.2385 mL 0.5964 mL
80 mM 0.0179 mL 0.0895 mL 0.1789 mL 0.4473 mL
100 mM 0.0143 mL 0.0716 mL 0.1431 mL 0.3578 mL
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STAT6-IN-7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT6-IN-73033743-58-4STATInterleukin RelatedILatopic dermatitisSTAT6Inhibitorinhibitorinhibit

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