Gpr35 - G protein-coupled receptor 35 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 367315

About Gpr35

Primary_assembly 9: 93,527,127-93,539,299 forward strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 228 orthologues, 14 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 9.6), Thymus (RPKM 4.6) and 6 other tissues.

Summary

Predicted to enable C-X-C Chemokine Receptor activity. Involved in negative regulation of neuronal action potential. Located in plasma membrane. Orthologous to human GPR35 (G protein-coupled receptor 35). [provided by Alliance of Genome Resources, Apr 2022]

Gpr35 Products (1)

mRNA Protein Name
NM_001037359.2 NP_001032436.2 G-protein coupled receptor 35

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
17996730 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of neuronal action potential IMP
IMP: Inferred from mutant phenotype
17940199 RGD
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
16754668 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr35 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (38 - 284)

7tm_GPCRs

7tm_GPCRs: cd14964 (51 - 72)

7tm_GPCRs

7tm_GPCRs: cd14964 (86 - 108)

7tm_GPCRs

7tm_GPCRs: cd14964 (131 - 147)

7tm_GPCRs

7tm_GPCRs: cd14964 (166 - 189)

7tm_GPCRs

7tm_GPCRs: cd14964 (213 - 235)

7tm_GPCRs

7tm_GPCRs: cd14964 (252 - 277)

  • 0
  • 100
  • 200
  • 306 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 35

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-100806 Kynurenic acid Agonist 99.93% Phase 1
HY-100806R Kynurenic acid (Standard) Agonist 98.87% Phase 1

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1816 Zaprinast Agonist 99.88% Unkown
HY-107537 CID 2745687 Agonist 99.35% Unkown
HY-W008613 Pamoic acid Agonist 99.69% Unkown
HY-100806S Kynurenic acid-d5 Agonist 99.85% Unkown
HY-107512 Kynurenic acid sodium Agonist 99.82% Unkown
HY-W018158 DHICA Activator 96.91% Unkown
HY-107536 ML 145 96.09% Unkown
HY-W010907 Pamoic acid disodium Agonist 99.86% Unkown
HY-16639 ML314 99.52% Unkown
HY-101033 GPR35 agonist 1 99.89% Unkown
HY-134801 CID1231538 99.26% Unkown
HY-106481 Bufrolin Agonist 95.16% Unkown
HY-15705 GPR35 agonist 2 Agonist 98.61% Unkown
HY-107539 GPR35 agonist 4 Agonist 99.32% Unkown
HY-107538 YE120 Agonist 99.93% Unkown
HY-101958 Tyrphostin 25 Agonist 99.00% Unkown
HY-149190 GPR35 agonist 5 Agonist 98.86% Unkown
HY-W018158R DHICA (Standard) Activator 95.20% Unkown
HY-169301 Gpr35 modulator 1 Modulator / Unkown
HY-169302 GPR35 activator-1 Activator / Unkown
HY-169303 Gpr35 modulator 2 Modulator / Unkown
HY-169304 Gpr35 modulator 3 Modulator / Unkown
HY-131728 GPR35 agonist 3 Agonist 98.32% Unkown
HY-W1058476 GPR35 agonist 6 Agonist / Unkown
HY-167706 Diethyl-Lodoxamide / Unkown
HY-178725 ML301 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr35 NCBI NCBI:2859